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Metal–Organic Frameworks (MOFs) and Their Composites as Emerging Biomaterials for Osteoarthritis Treatment

Metal-Organic Frameworks (MOFs) have emerged as a novel component in biomaterial formulations over the past 5 years. The bioactivity of MOFs in bone or cartilage tissue is mediated through the sustained delivery of metal ions, bioactive ligands, or drug molecules that are loaded into the porous MOF...

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Autores principales: Wong, Hoi-Lam, Tsang, Chung-Yin, Beyer, Sebastian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10046764/
https://www.ncbi.nlm.nih.gov/pubmed/36975327
http://dx.doi.org/10.3390/biomimetics8010097
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author Wong, Hoi-Lam
Tsang, Chung-Yin
Beyer, Sebastian
author_facet Wong, Hoi-Lam
Tsang, Chung-Yin
Beyer, Sebastian
author_sort Wong, Hoi-Lam
collection PubMed
description Metal-Organic Frameworks (MOFs) have emerged as a novel component in biomaterial formulations over the past 5 years. The bioactivity of MOFs in bone or cartilage tissue is mediated through the sustained delivery of metal ions, bioactive ligands, or drug molecules that are loaded into the porous MOF structures. Alternatively, bioactivity may also originate from structure-specific properties. The latter includes the availability and accessibility of open metal coordination sites for the catalytic conversion of biomolecules into active agents. This narrative highlight aims to inspire strategies to utilize MOFs for treating osteoarthritis (OA), with a special focus on augmenting hydrogel-based biomaterials with MOFs. The added value of MOFs in these hydrogel formulations is discussed, and the biological efficacy is compared to approaches applying classical injectable biomaterials for OA treatment. Possible future directions and pitfalls of these novel MOF–hydrogel composites are emphasized to assist future transition of MOFs into clinical applications.
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spelling pubmed-100467642023-03-29 Metal–Organic Frameworks (MOFs) and Their Composites as Emerging Biomaterials for Osteoarthritis Treatment Wong, Hoi-Lam Tsang, Chung-Yin Beyer, Sebastian Biomimetics (Basel) Perspective Metal-Organic Frameworks (MOFs) have emerged as a novel component in biomaterial formulations over the past 5 years. The bioactivity of MOFs in bone or cartilage tissue is mediated through the sustained delivery of metal ions, bioactive ligands, or drug molecules that are loaded into the porous MOF structures. Alternatively, bioactivity may also originate from structure-specific properties. The latter includes the availability and accessibility of open metal coordination sites for the catalytic conversion of biomolecules into active agents. This narrative highlight aims to inspire strategies to utilize MOFs for treating osteoarthritis (OA), with a special focus on augmenting hydrogel-based biomaterials with MOFs. The added value of MOFs in these hydrogel formulations is discussed, and the biological efficacy is compared to approaches applying classical injectable biomaterials for OA treatment. Possible future directions and pitfalls of these novel MOF–hydrogel composites are emphasized to assist future transition of MOFs into clinical applications. MDPI 2023-02-27 /pmc/articles/PMC10046764/ /pubmed/36975327 http://dx.doi.org/10.3390/biomimetics8010097 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Perspective
Wong, Hoi-Lam
Tsang, Chung-Yin
Beyer, Sebastian
Metal–Organic Frameworks (MOFs) and Their Composites as Emerging Biomaterials for Osteoarthritis Treatment
title Metal–Organic Frameworks (MOFs) and Their Composites as Emerging Biomaterials for Osteoarthritis Treatment
title_full Metal–Organic Frameworks (MOFs) and Their Composites as Emerging Biomaterials for Osteoarthritis Treatment
title_fullStr Metal–Organic Frameworks (MOFs) and Their Composites as Emerging Biomaterials for Osteoarthritis Treatment
title_full_unstemmed Metal–Organic Frameworks (MOFs) and Their Composites as Emerging Biomaterials for Osteoarthritis Treatment
title_short Metal–Organic Frameworks (MOFs) and Their Composites as Emerging Biomaterials for Osteoarthritis Treatment
title_sort metal–organic frameworks (mofs) and their composites as emerging biomaterials for osteoarthritis treatment
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10046764/
https://www.ncbi.nlm.nih.gov/pubmed/36975327
http://dx.doi.org/10.3390/biomimetics8010097
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