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Transmission of pancreatic adenocarcinoma by a single multiorgan donor to two kidney transplant recipients: A case report

We present two cases of transmission of a pancreatic adenocarcinoma from a single donor to two kidney transplant recipients. Autopsy of the donor revealed a pancreatic adenocarcinoma that had already spread locally to the regional lymph nodes and had not been detected at the time of organ procuremen...

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Autores principales: Belčič Mikič, Tanja, Mlinšek, Gregor, Oblak, Manca, Kandus, Aljoša, Buturović-Ponikvar, Jadranka, Hawlina, Simon, Milanez, Tomaž, Kojc, Nika, Frelih, Maja, Arnol, Miha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10046802/
https://www.ncbi.nlm.nih.gov/pubmed/36999065
http://dx.doi.org/10.3389/fmed.2023.1142611
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author Belčič Mikič, Tanja
Mlinšek, Gregor
Oblak, Manca
Kandus, Aljoša
Buturović-Ponikvar, Jadranka
Hawlina, Simon
Milanez, Tomaž
Kojc, Nika
Frelih, Maja
Arnol, Miha
author_facet Belčič Mikič, Tanja
Mlinšek, Gregor
Oblak, Manca
Kandus, Aljoša
Buturović-Ponikvar, Jadranka
Hawlina, Simon
Milanez, Tomaž
Kojc, Nika
Frelih, Maja
Arnol, Miha
author_sort Belčič Mikič, Tanja
collection PubMed
description We present two cases of transmission of a pancreatic adenocarcinoma from a single donor to two kidney transplant recipients. Autopsy of the donor revealed a pancreatic adenocarcinoma that had already spread locally to the regional lymph nodes and had not been detected at the time of organ procurement. Both recipients were carefully monitored, as neither consented to graft nephrectomy. In one patient, the tumor was discovered on surveillance biopsy of the graft approximately 14 months after transplantation, and in the second patient, ultrasound-guided aspiration needle biopsy of a growing formation in the lower pole of the graft revealed poorly differentiated metastatic adenocarcinoma. Both patients were successfully treated with graft nephrectomy and complete discontinuation of immunosuppression. None of the follow-up imaging showed persistent or recurrent malignancy, and both patients were candidates for re-transplantation. These exceptional cases of donor-derived pancreatic adenocarcinoma suggest that removal of the donor organ and restoration of immunity may lead to complete recovery.
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spelling pubmed-100468022023-03-29 Transmission of pancreatic adenocarcinoma by a single multiorgan donor to two kidney transplant recipients: A case report Belčič Mikič, Tanja Mlinšek, Gregor Oblak, Manca Kandus, Aljoša Buturović-Ponikvar, Jadranka Hawlina, Simon Milanez, Tomaž Kojc, Nika Frelih, Maja Arnol, Miha Front Med (Lausanne) Medicine We present two cases of transmission of a pancreatic adenocarcinoma from a single donor to two kidney transplant recipients. Autopsy of the donor revealed a pancreatic adenocarcinoma that had already spread locally to the regional lymph nodes and had not been detected at the time of organ procurement. Both recipients were carefully monitored, as neither consented to graft nephrectomy. In one patient, the tumor was discovered on surveillance biopsy of the graft approximately 14 months after transplantation, and in the second patient, ultrasound-guided aspiration needle biopsy of a growing formation in the lower pole of the graft revealed poorly differentiated metastatic adenocarcinoma. Both patients were successfully treated with graft nephrectomy and complete discontinuation of immunosuppression. None of the follow-up imaging showed persistent or recurrent malignancy, and both patients were candidates for re-transplantation. These exceptional cases of donor-derived pancreatic adenocarcinoma suggest that removal of the donor organ and restoration of immunity may lead to complete recovery. Frontiers Media S.A. 2023-03-14 /pmc/articles/PMC10046802/ /pubmed/36999065 http://dx.doi.org/10.3389/fmed.2023.1142611 Text en Copyright © 2023 Belčič Mikič, Mlinšek, Oblak, Kandus, Buturović-Ponikvar, Hawlina, Milanez, Kojc, Frelih and Arnol. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Belčič Mikič, Tanja
Mlinšek, Gregor
Oblak, Manca
Kandus, Aljoša
Buturović-Ponikvar, Jadranka
Hawlina, Simon
Milanez, Tomaž
Kojc, Nika
Frelih, Maja
Arnol, Miha
Transmission of pancreatic adenocarcinoma by a single multiorgan donor to two kidney transplant recipients: A case report
title Transmission of pancreatic adenocarcinoma by a single multiorgan donor to two kidney transplant recipients: A case report
title_full Transmission of pancreatic adenocarcinoma by a single multiorgan donor to two kidney transplant recipients: A case report
title_fullStr Transmission of pancreatic adenocarcinoma by a single multiorgan donor to two kidney transplant recipients: A case report
title_full_unstemmed Transmission of pancreatic adenocarcinoma by a single multiorgan donor to two kidney transplant recipients: A case report
title_short Transmission of pancreatic adenocarcinoma by a single multiorgan donor to two kidney transplant recipients: A case report
title_sort transmission of pancreatic adenocarcinoma by a single multiorgan donor to two kidney transplant recipients: a case report
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10046802/
https://www.ncbi.nlm.nih.gov/pubmed/36999065
http://dx.doi.org/10.3389/fmed.2023.1142611
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