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Inhibition of IDH3α Enhanced the Efficacy of Chemoimmunotherapy by Regulating Acidic Tumor Microenvironments

SIMPLE SUMMARY: Isocitrate dehydrogenase 3α (IDH3α) is highly expressed in many cancers and is associated with poor patient prognosis. However, it is not clear whether the aberrant expression of IDH3α is related to the efficacy of chemoimmunotherapy against cancer. We used in vivo and in vitro exper...

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Detalles Bibliográficos
Autores principales: Zhang, Lingling, Song, Yang, Dai, Xiaoyan, Xu, Wenwen, Li, Mengxia, Zhu, Yuxi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10046804/
https://www.ncbi.nlm.nih.gov/pubmed/36980689
http://dx.doi.org/10.3390/cancers15061802