Cargando…

Neurocognitive Psychiatric and Neuropsychological Alterations in Parkinson’s Disease: A Basic and Clinical Approach

The main histopathological hallmarks of Parkinson’s disease (PD) are the degeneration of the dopaminergic neurons of the substantia nigra pars compacta and the loss of neuromelanin as a consequence of decreased dopamine synthesis. The destruction of the striatal dopaminergic pathway and blocking of...

Descripción completa

Detalles Bibliográficos
Autores principales: González-Usigli, Héctor Alberto, Ortiz, Genaro Gabriel, Charles-Niño, Claudia, Mireles-Ramírez, Mario Alberto, Pacheco-Moisés, Fermín Paul, Torres-Mendoza, Blanca Miriam de Guadalupe, Hernández-Cruz, José de Jesús, Delgado-Lara, Daniela Lucero del Carmen, Ramírez-Jirano, Luis Javier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10046896/
https://www.ncbi.nlm.nih.gov/pubmed/36979318
http://dx.doi.org/10.3390/brainsci13030508
_version_ 1785013786821787648
author González-Usigli, Héctor Alberto
Ortiz, Genaro Gabriel
Charles-Niño, Claudia
Mireles-Ramírez, Mario Alberto
Pacheco-Moisés, Fermín Paul
Torres-Mendoza, Blanca Miriam de Guadalupe
Hernández-Cruz, José de Jesús
Delgado-Lara, Daniela Lucero del Carmen
Ramírez-Jirano, Luis Javier
author_facet González-Usigli, Héctor Alberto
Ortiz, Genaro Gabriel
Charles-Niño, Claudia
Mireles-Ramírez, Mario Alberto
Pacheco-Moisés, Fermín Paul
Torres-Mendoza, Blanca Miriam de Guadalupe
Hernández-Cruz, José de Jesús
Delgado-Lara, Daniela Lucero del Carmen
Ramírez-Jirano, Luis Javier
author_sort González-Usigli, Héctor Alberto
collection PubMed
description The main histopathological hallmarks of Parkinson’s disease (PD) are the degeneration of the dopaminergic neurons of the substantia nigra pars compacta and the loss of neuromelanin as a consequence of decreased dopamine synthesis. The destruction of the striatal dopaminergic pathway and blocking of striatal dopamine receptors cause motor deficits in humans and experimental animal models induced by some environmental agents. In addition, neuropsychiatric symptoms such as mood and anxiety disorders, hallucinations, psychosis, cognitive impairment, and dementia are common in PD. These alterations may precede the appearance of motor symptoms and are correlated with neurochemical and structural changes in the brain. This paper reviews the most crucial pathophysiology of neuropsychiatric alterations in PD. It is worth noting that PD patients have global task learning deficits, and cognitive functions are compromised in a way is associated with hypoactivation within the striatum, anterior cingulate cortex, and inferior frontal sulcus regions. An appropriate and extensive neuropsychological screening battery in PD must accurately assess at least five cognitive domains with some tests for each cognitive domain. This neuropsychological screening should consider the pathophysiological and clinical heterogeneity of cognitive dysfunction in PD.
format Online
Article
Text
id pubmed-10046896
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-100468962023-03-29 Neurocognitive Psychiatric and Neuropsychological Alterations in Parkinson’s Disease: A Basic and Clinical Approach González-Usigli, Héctor Alberto Ortiz, Genaro Gabriel Charles-Niño, Claudia Mireles-Ramírez, Mario Alberto Pacheco-Moisés, Fermín Paul Torres-Mendoza, Blanca Miriam de Guadalupe Hernández-Cruz, José de Jesús Delgado-Lara, Daniela Lucero del Carmen Ramírez-Jirano, Luis Javier Brain Sci Review The main histopathological hallmarks of Parkinson’s disease (PD) are the degeneration of the dopaminergic neurons of the substantia nigra pars compacta and the loss of neuromelanin as a consequence of decreased dopamine synthesis. The destruction of the striatal dopaminergic pathway and blocking of striatal dopamine receptors cause motor deficits in humans and experimental animal models induced by some environmental agents. In addition, neuropsychiatric symptoms such as mood and anxiety disorders, hallucinations, psychosis, cognitive impairment, and dementia are common in PD. These alterations may precede the appearance of motor symptoms and are correlated with neurochemical and structural changes in the brain. This paper reviews the most crucial pathophysiology of neuropsychiatric alterations in PD. It is worth noting that PD patients have global task learning deficits, and cognitive functions are compromised in a way is associated with hypoactivation within the striatum, anterior cingulate cortex, and inferior frontal sulcus regions. An appropriate and extensive neuropsychological screening battery in PD must accurately assess at least five cognitive domains with some tests for each cognitive domain. This neuropsychological screening should consider the pathophysiological and clinical heterogeneity of cognitive dysfunction in PD. MDPI 2023-03-18 /pmc/articles/PMC10046896/ /pubmed/36979318 http://dx.doi.org/10.3390/brainsci13030508 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
González-Usigli, Héctor Alberto
Ortiz, Genaro Gabriel
Charles-Niño, Claudia
Mireles-Ramírez, Mario Alberto
Pacheco-Moisés, Fermín Paul
Torres-Mendoza, Blanca Miriam de Guadalupe
Hernández-Cruz, José de Jesús
Delgado-Lara, Daniela Lucero del Carmen
Ramírez-Jirano, Luis Javier
Neurocognitive Psychiatric and Neuropsychological Alterations in Parkinson’s Disease: A Basic and Clinical Approach
title Neurocognitive Psychiatric and Neuropsychological Alterations in Parkinson’s Disease: A Basic and Clinical Approach
title_full Neurocognitive Psychiatric and Neuropsychological Alterations in Parkinson’s Disease: A Basic and Clinical Approach
title_fullStr Neurocognitive Psychiatric and Neuropsychological Alterations in Parkinson’s Disease: A Basic and Clinical Approach
title_full_unstemmed Neurocognitive Psychiatric and Neuropsychological Alterations in Parkinson’s Disease: A Basic and Clinical Approach
title_short Neurocognitive Psychiatric and Neuropsychological Alterations in Parkinson’s Disease: A Basic and Clinical Approach
title_sort neurocognitive psychiatric and neuropsychological alterations in parkinson’s disease: a basic and clinical approach
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10046896/
https://www.ncbi.nlm.nih.gov/pubmed/36979318
http://dx.doi.org/10.3390/brainsci13030508
work_keys_str_mv AT gonzalezusiglihectoralberto neurocognitivepsychiatricandneuropsychologicalalterationsinparkinsonsdiseaseabasicandclinicalapproach
AT ortizgenarogabriel neurocognitivepsychiatricandneuropsychologicalalterationsinparkinsonsdiseaseabasicandclinicalapproach
AT charlesninoclaudia neurocognitivepsychiatricandneuropsychologicalalterationsinparkinsonsdiseaseabasicandclinicalapproach
AT mirelesramirezmarioalberto neurocognitivepsychiatricandneuropsychologicalalterationsinparkinsonsdiseaseabasicandclinicalapproach
AT pachecomoisesferminpaul neurocognitivepsychiatricandneuropsychologicalalterationsinparkinsonsdiseaseabasicandclinicalapproach
AT torresmendozablancamiriamdeguadalupe neurocognitivepsychiatricandneuropsychologicalalterationsinparkinsonsdiseaseabasicandclinicalapproach
AT hernandezcruzjosedejesus neurocognitivepsychiatricandneuropsychologicalalterationsinparkinsonsdiseaseabasicandclinicalapproach
AT delgadolaradanielalucerodelcarmen neurocognitivepsychiatricandneuropsychologicalalterationsinparkinsonsdiseaseabasicandclinicalapproach
AT ramirezjiranoluisjavier neurocognitivepsychiatricandneuropsychologicalalterationsinparkinsonsdiseaseabasicandclinicalapproach