Extracellular Lactic Acidosis of the Tumor Microenvironment Drives Adipocyte-to-Myofibroblast Transition Fueling the Generation of Cancer-Associated Fibroblasts

Lactic acidosis characterizes the tumor microenvironment (TME) and is involved in the mechanisms leading to cancer progression and dissemination through the reprogramming of tumor and local host cells (e.g., endothelial cells, fibroblasts, and immune cells). Adipose tissue also represents a crucial...

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Detalles Bibliográficos
Autores principales: Andreucci, Elena, Fioretto, Bianca Saveria, Rosa, Irene, Matucci-Cerinic, Marco, Biagioni, Alessio, Romano, Eloisa, Calorini, Lido, Manetti, Mirko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10046917/
https://www.ncbi.nlm.nih.gov/pubmed/36980280
http://dx.doi.org/10.3390/cells12060939

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