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Incidence of Concomitant Neoplastic Diseases, Tumor Characteristics, and the Survival of Patients with Lung Adenocarcinoma or Squamous Cell Lung Carcinoma in Tobacco Smokers and Non-Smokers—10-Year Retrospective Single-Centre Cohort Study

SIMPLE SUMMARY: Lung cancer is one of the biggest public health issues due to its high prevalence and mortality. Currently, increasing consideration is given to the incidence of lung cancer in the individuals with no lifetime history of tobacco smoking. However, up-to-date data on the characteristic...

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Autores principales: Ochman, Błażej, Kiczmer, Paweł, Ziora, Paweł, Rydel, Mateusz, Borowiecki, Maciej, Czyżewski, Damian, Drozdzowska, Bogna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10046928/
https://www.ncbi.nlm.nih.gov/pubmed/36980781
http://dx.doi.org/10.3390/cancers15061896
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author Ochman, Błażej
Kiczmer, Paweł
Ziora, Paweł
Rydel, Mateusz
Borowiecki, Maciej
Czyżewski, Damian
Drozdzowska, Bogna
author_facet Ochman, Błażej
Kiczmer, Paweł
Ziora, Paweł
Rydel, Mateusz
Borowiecki, Maciej
Czyżewski, Damian
Drozdzowska, Bogna
author_sort Ochman, Błażej
collection PubMed
description SIMPLE SUMMARY: Lung cancer is one of the biggest public health issues due to its high prevalence and mortality. Currently, increasing consideration is given to the incidence of lung cancer in the individuals with no lifetime history of tobacco smoking. However, up-to-date data on the characteristics of a group of non-smokers with lung cancer are limited. The current literature also contains gaps in the differences in the clinical course of lung cancer in smokers and non-smokers. This study aimed to investigate the differences in tumor characteristics, survival rates, and comorbidities between a group of smokers and a group of non-smokers with lung cancer. The presented results may be used in clinical practice and in shaping future lung cancer prevention programs. ABSTRACT: Changes in smoking trends and changes in lifestyle, together with worldwide data regarding the incidence of lung cancer in the group of patients with no previous history of smoking, leads to consideration of the differences in the course of the disease, the time of cancer diagnosis, the survival rate, and the occurrence of comorbidities in this group of patients. This study aimed to determine the occurrence of non-smokers among patients undergoing anatomical resection of the lung tissue due to lung carcinoma and to investigate the differences between the course of lung cancer, survival, and the comorbidities in the groups of patients with lung cancer depending on the history of tobacco smoking. The study included a cohort of 923 patients who underwent radical anatomical resection of the lung tissue with lung primary adenocarcinoma or squamous cell carcinoma. The Chi2 Pearson’s test, the t-test, the Mann–Whitney U test, the Kaplan–Meier method, the Log-rank test with Mantel correction, and the Cox proportional hazard model were used for data analysis. We observed a significantly higher mean age of smoking patients compared to the mean age of non-smoking patients. The coexistence of former neoplastic diseases was significantly more frequent in the group of non-smokers compared to the group of smoking patients. We did not observe differences depending on smoking status in the tumor stage, grade, vascular and pleural involvement status in the diagnostic reports. We did not observe differences in the survival between smokers vs. non-smokers, however, we revealed better survival in the non-smoker women group compared to the non-smoker men group. In conclusion, 22.11% of the patients undergoing radical anatomical resection of the lung tissue due to lung cancers were non-smokers. More research on survival depending on genetic differences and postoperative treatment between smokers and non-smokers is necessary.
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spelling pubmed-100469282023-03-29 Incidence of Concomitant Neoplastic Diseases, Tumor Characteristics, and the Survival of Patients with Lung Adenocarcinoma or Squamous Cell Lung Carcinoma in Tobacco Smokers and Non-Smokers—10-Year Retrospective Single-Centre Cohort Study Ochman, Błażej Kiczmer, Paweł Ziora, Paweł Rydel, Mateusz Borowiecki, Maciej Czyżewski, Damian Drozdzowska, Bogna Cancers (Basel) Article SIMPLE SUMMARY: Lung cancer is one of the biggest public health issues due to its high prevalence and mortality. Currently, increasing consideration is given to the incidence of lung cancer in the individuals with no lifetime history of tobacco smoking. However, up-to-date data on the characteristics of a group of non-smokers with lung cancer are limited. The current literature also contains gaps in the differences in the clinical course of lung cancer in smokers and non-smokers. This study aimed to investigate the differences in tumor characteristics, survival rates, and comorbidities between a group of smokers and a group of non-smokers with lung cancer. The presented results may be used in clinical practice and in shaping future lung cancer prevention programs. ABSTRACT: Changes in smoking trends and changes in lifestyle, together with worldwide data regarding the incidence of lung cancer in the group of patients with no previous history of smoking, leads to consideration of the differences in the course of the disease, the time of cancer diagnosis, the survival rate, and the occurrence of comorbidities in this group of patients. This study aimed to determine the occurrence of non-smokers among patients undergoing anatomical resection of the lung tissue due to lung carcinoma and to investigate the differences between the course of lung cancer, survival, and the comorbidities in the groups of patients with lung cancer depending on the history of tobacco smoking. The study included a cohort of 923 patients who underwent radical anatomical resection of the lung tissue with lung primary adenocarcinoma or squamous cell carcinoma. The Chi2 Pearson’s test, the t-test, the Mann–Whitney U test, the Kaplan–Meier method, the Log-rank test with Mantel correction, and the Cox proportional hazard model were used for data analysis. We observed a significantly higher mean age of smoking patients compared to the mean age of non-smoking patients. The coexistence of former neoplastic diseases was significantly more frequent in the group of non-smokers compared to the group of smoking patients. We did not observe differences depending on smoking status in the tumor stage, grade, vascular and pleural involvement status in the diagnostic reports. We did not observe differences in the survival between smokers vs. non-smokers, however, we revealed better survival in the non-smoker women group compared to the non-smoker men group. In conclusion, 22.11% of the patients undergoing radical anatomical resection of the lung tissue due to lung cancers were non-smokers. More research on survival depending on genetic differences and postoperative treatment between smokers and non-smokers is necessary. MDPI 2023-03-22 /pmc/articles/PMC10046928/ /pubmed/36980781 http://dx.doi.org/10.3390/cancers15061896 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ochman, Błażej
Kiczmer, Paweł
Ziora, Paweł
Rydel, Mateusz
Borowiecki, Maciej
Czyżewski, Damian
Drozdzowska, Bogna
Incidence of Concomitant Neoplastic Diseases, Tumor Characteristics, and the Survival of Patients with Lung Adenocarcinoma or Squamous Cell Lung Carcinoma in Tobacco Smokers and Non-Smokers—10-Year Retrospective Single-Centre Cohort Study
title Incidence of Concomitant Neoplastic Diseases, Tumor Characteristics, and the Survival of Patients with Lung Adenocarcinoma or Squamous Cell Lung Carcinoma in Tobacco Smokers and Non-Smokers—10-Year Retrospective Single-Centre Cohort Study
title_full Incidence of Concomitant Neoplastic Diseases, Tumor Characteristics, and the Survival of Patients with Lung Adenocarcinoma or Squamous Cell Lung Carcinoma in Tobacco Smokers and Non-Smokers—10-Year Retrospective Single-Centre Cohort Study
title_fullStr Incidence of Concomitant Neoplastic Diseases, Tumor Characteristics, and the Survival of Patients with Lung Adenocarcinoma or Squamous Cell Lung Carcinoma in Tobacco Smokers and Non-Smokers—10-Year Retrospective Single-Centre Cohort Study
title_full_unstemmed Incidence of Concomitant Neoplastic Diseases, Tumor Characteristics, and the Survival of Patients with Lung Adenocarcinoma or Squamous Cell Lung Carcinoma in Tobacco Smokers and Non-Smokers—10-Year Retrospective Single-Centre Cohort Study
title_short Incidence of Concomitant Neoplastic Diseases, Tumor Characteristics, and the Survival of Patients with Lung Adenocarcinoma or Squamous Cell Lung Carcinoma in Tobacco Smokers and Non-Smokers—10-Year Retrospective Single-Centre Cohort Study
title_sort incidence of concomitant neoplastic diseases, tumor characteristics, and the survival of patients with lung adenocarcinoma or squamous cell lung carcinoma in tobacco smokers and non-smokers—10-year retrospective single-centre cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10046928/
https://www.ncbi.nlm.nih.gov/pubmed/36980781
http://dx.doi.org/10.3390/cancers15061896
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