Mechanistic Insights into the Role of OPN in Mediating Brain Damage via Triggering Lysosomal Damage in Microglia/Macrophage

We previously found that osteopontin (OPN) played a role in hypoxia–ischemia (HI) brain damage. However, its underlying mechanism is still unknown. Bioinformatics analysis revealed that the OPN protein was linked to the lysosomal cathepsin B (CTSB) and galectin-3 (GAL-3) proteins after HI exposure....

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Detalles Bibliográficos
Autores principales: Gai, Chengcheng, Zhao, Yijing, Xin, Danqing, Li, Tingting, Cheng, Yahong, Jiang, Zige, Song, Yan, Liu, Dexiang, Wang, Zhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10046941/
https://www.ncbi.nlm.nih.gov/pubmed/36980197
http://dx.doi.org/10.3390/cells12060854

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10046941/
https://www.ncbi.nlm.nih.gov/pubmed/36980197
http://dx.doi.org/10.3390/cells12060854

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