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Radiofrequency Ablation in Vertebral Body Metastasis with and without Percutaneous Cement Augmentation: A Systematic Review Addressing the Need for SPINE Stability Evaluation

Vertebral body metastases (VBM) are one of the most frequent sites of bone metastasis, and their adequate therapeutic management still represents an insidious challenge for both oncologists and surgeons. A possible alternative treatment for VBM is radiofrequency ablation (RFA), a percutaneous techni...

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Autores principales: Colonna, Stefano, Bianconi, Andrea, Cofano, Fabio, Prior, Alessandro, Di Perna, Giuseppe, Palmieri, Giuseppe, Zona, Gianluigi, Garbossa, Diego, Fiaschi, Pietro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10046948/
https://www.ncbi.nlm.nih.gov/pubmed/36980472
http://dx.doi.org/10.3390/diagnostics13061164
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author Colonna, Stefano
Bianconi, Andrea
Cofano, Fabio
Prior, Alessandro
Di Perna, Giuseppe
Palmieri, Giuseppe
Zona, Gianluigi
Garbossa, Diego
Fiaschi, Pietro
author_facet Colonna, Stefano
Bianconi, Andrea
Cofano, Fabio
Prior, Alessandro
Di Perna, Giuseppe
Palmieri, Giuseppe
Zona, Gianluigi
Garbossa, Diego
Fiaschi, Pietro
author_sort Colonna, Stefano
collection PubMed
description Vertebral body metastases (VBM) are one of the most frequent sites of bone metastasis, and their adequate therapeutic management still represents an insidious challenge for both oncologists and surgeons. A possible alternative treatment for VBM is radiofrequency ablation (RFA), a percutaneous technique in which an alternating current is delivered to the tumor lesion producing local heating and consequent necrosis. However, RFA alone could alter the biomechanics and microanatomy of the vertebral body, thus increasing the risk of post-procedure vertebral fractures and spine instability, and indeed the aim of the present study is to investigate the effects of RFA on spine stability. A systematic review according to PRISMA-P guidelines was performed, and 17 papers were selected for the systematic review. The results show how RFA is an effective, safe, and feasible alternative to conventional radiotherapy for the treatment of VBM without indication for surgery, but spine stability is a major issue in this context. Although exerting undeniable benefits on pain control and local tumor recurrence, RFA alone increases the risk of spine instability and consequent vertebral body fractures and collapses. Concomitant safe and feasible therapeutic strategies such as percutaneous vertebroplasty and kyphoplasty have shown synergic positive effects on back pain and improvement in spine stability.
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spelling pubmed-100469482023-03-29 Radiofrequency Ablation in Vertebral Body Metastasis with and without Percutaneous Cement Augmentation: A Systematic Review Addressing the Need for SPINE Stability Evaluation Colonna, Stefano Bianconi, Andrea Cofano, Fabio Prior, Alessandro Di Perna, Giuseppe Palmieri, Giuseppe Zona, Gianluigi Garbossa, Diego Fiaschi, Pietro Diagnostics (Basel) Systematic Review Vertebral body metastases (VBM) are one of the most frequent sites of bone metastasis, and their adequate therapeutic management still represents an insidious challenge for both oncologists and surgeons. A possible alternative treatment for VBM is radiofrequency ablation (RFA), a percutaneous technique in which an alternating current is delivered to the tumor lesion producing local heating and consequent necrosis. However, RFA alone could alter the biomechanics and microanatomy of the vertebral body, thus increasing the risk of post-procedure vertebral fractures and spine instability, and indeed the aim of the present study is to investigate the effects of RFA on spine stability. A systematic review according to PRISMA-P guidelines was performed, and 17 papers were selected for the systematic review. The results show how RFA is an effective, safe, and feasible alternative to conventional radiotherapy for the treatment of VBM without indication for surgery, but spine stability is a major issue in this context. Although exerting undeniable benefits on pain control and local tumor recurrence, RFA alone increases the risk of spine instability and consequent vertebral body fractures and collapses. Concomitant safe and feasible therapeutic strategies such as percutaneous vertebroplasty and kyphoplasty have shown synergic positive effects on back pain and improvement in spine stability. MDPI 2023-03-18 /pmc/articles/PMC10046948/ /pubmed/36980472 http://dx.doi.org/10.3390/diagnostics13061164 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Systematic Review
Colonna, Stefano
Bianconi, Andrea
Cofano, Fabio
Prior, Alessandro
Di Perna, Giuseppe
Palmieri, Giuseppe
Zona, Gianluigi
Garbossa, Diego
Fiaschi, Pietro
Radiofrequency Ablation in Vertebral Body Metastasis with and without Percutaneous Cement Augmentation: A Systematic Review Addressing the Need for SPINE Stability Evaluation
title Radiofrequency Ablation in Vertebral Body Metastasis with and without Percutaneous Cement Augmentation: A Systematic Review Addressing the Need for SPINE Stability Evaluation
title_full Radiofrequency Ablation in Vertebral Body Metastasis with and without Percutaneous Cement Augmentation: A Systematic Review Addressing the Need for SPINE Stability Evaluation
title_fullStr Radiofrequency Ablation in Vertebral Body Metastasis with and without Percutaneous Cement Augmentation: A Systematic Review Addressing the Need for SPINE Stability Evaluation
title_full_unstemmed Radiofrequency Ablation in Vertebral Body Metastasis with and without Percutaneous Cement Augmentation: A Systematic Review Addressing the Need for SPINE Stability Evaluation
title_short Radiofrequency Ablation in Vertebral Body Metastasis with and without Percutaneous Cement Augmentation: A Systematic Review Addressing the Need for SPINE Stability Evaluation
title_sort radiofrequency ablation in vertebral body metastasis with and without percutaneous cement augmentation: a systematic review addressing the need for spine stability evaluation
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10046948/
https://www.ncbi.nlm.nih.gov/pubmed/36980472
http://dx.doi.org/10.3390/diagnostics13061164
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