Cargando…
Radiofrequency Ablation in Vertebral Body Metastasis with and without Percutaneous Cement Augmentation: A Systematic Review Addressing the Need for SPINE Stability Evaluation
Vertebral body metastases (VBM) are one of the most frequent sites of bone metastasis, and their adequate therapeutic management still represents an insidious challenge for both oncologists and surgeons. A possible alternative treatment for VBM is radiofrequency ablation (RFA), a percutaneous techni...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10046948/ https://www.ncbi.nlm.nih.gov/pubmed/36980472 http://dx.doi.org/10.3390/diagnostics13061164 |
_version_ | 1785013799761215488 |
---|---|
author | Colonna, Stefano Bianconi, Andrea Cofano, Fabio Prior, Alessandro Di Perna, Giuseppe Palmieri, Giuseppe Zona, Gianluigi Garbossa, Diego Fiaschi, Pietro |
author_facet | Colonna, Stefano Bianconi, Andrea Cofano, Fabio Prior, Alessandro Di Perna, Giuseppe Palmieri, Giuseppe Zona, Gianluigi Garbossa, Diego Fiaschi, Pietro |
author_sort | Colonna, Stefano |
collection | PubMed |
description | Vertebral body metastases (VBM) are one of the most frequent sites of bone metastasis, and their adequate therapeutic management still represents an insidious challenge for both oncologists and surgeons. A possible alternative treatment for VBM is radiofrequency ablation (RFA), a percutaneous technique in which an alternating current is delivered to the tumor lesion producing local heating and consequent necrosis. However, RFA alone could alter the biomechanics and microanatomy of the vertebral body, thus increasing the risk of post-procedure vertebral fractures and spine instability, and indeed the aim of the present study is to investigate the effects of RFA on spine stability. A systematic review according to PRISMA-P guidelines was performed, and 17 papers were selected for the systematic review. The results show how RFA is an effective, safe, and feasible alternative to conventional radiotherapy for the treatment of VBM without indication for surgery, but spine stability is a major issue in this context. Although exerting undeniable benefits on pain control and local tumor recurrence, RFA alone increases the risk of spine instability and consequent vertebral body fractures and collapses. Concomitant safe and feasible therapeutic strategies such as percutaneous vertebroplasty and kyphoplasty have shown synergic positive effects on back pain and improvement in spine stability. |
format | Online Article Text |
id | pubmed-10046948 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100469482023-03-29 Radiofrequency Ablation in Vertebral Body Metastasis with and without Percutaneous Cement Augmentation: A Systematic Review Addressing the Need for SPINE Stability Evaluation Colonna, Stefano Bianconi, Andrea Cofano, Fabio Prior, Alessandro Di Perna, Giuseppe Palmieri, Giuseppe Zona, Gianluigi Garbossa, Diego Fiaschi, Pietro Diagnostics (Basel) Systematic Review Vertebral body metastases (VBM) are one of the most frequent sites of bone metastasis, and their adequate therapeutic management still represents an insidious challenge for both oncologists and surgeons. A possible alternative treatment for VBM is radiofrequency ablation (RFA), a percutaneous technique in which an alternating current is delivered to the tumor lesion producing local heating and consequent necrosis. However, RFA alone could alter the biomechanics and microanatomy of the vertebral body, thus increasing the risk of post-procedure vertebral fractures and spine instability, and indeed the aim of the present study is to investigate the effects of RFA on spine stability. A systematic review according to PRISMA-P guidelines was performed, and 17 papers were selected for the systematic review. The results show how RFA is an effective, safe, and feasible alternative to conventional radiotherapy for the treatment of VBM without indication for surgery, but spine stability is a major issue in this context. Although exerting undeniable benefits on pain control and local tumor recurrence, RFA alone increases the risk of spine instability and consequent vertebral body fractures and collapses. Concomitant safe and feasible therapeutic strategies such as percutaneous vertebroplasty and kyphoplasty have shown synergic positive effects on back pain and improvement in spine stability. MDPI 2023-03-18 /pmc/articles/PMC10046948/ /pubmed/36980472 http://dx.doi.org/10.3390/diagnostics13061164 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Systematic Review Colonna, Stefano Bianconi, Andrea Cofano, Fabio Prior, Alessandro Di Perna, Giuseppe Palmieri, Giuseppe Zona, Gianluigi Garbossa, Diego Fiaschi, Pietro Radiofrequency Ablation in Vertebral Body Metastasis with and without Percutaneous Cement Augmentation: A Systematic Review Addressing the Need for SPINE Stability Evaluation |
title | Radiofrequency Ablation in Vertebral Body Metastasis with and without Percutaneous Cement Augmentation: A Systematic Review Addressing the Need for SPINE Stability Evaluation |
title_full | Radiofrequency Ablation in Vertebral Body Metastasis with and without Percutaneous Cement Augmentation: A Systematic Review Addressing the Need for SPINE Stability Evaluation |
title_fullStr | Radiofrequency Ablation in Vertebral Body Metastasis with and without Percutaneous Cement Augmentation: A Systematic Review Addressing the Need for SPINE Stability Evaluation |
title_full_unstemmed | Radiofrequency Ablation in Vertebral Body Metastasis with and without Percutaneous Cement Augmentation: A Systematic Review Addressing the Need for SPINE Stability Evaluation |
title_short | Radiofrequency Ablation in Vertebral Body Metastasis with and without Percutaneous Cement Augmentation: A Systematic Review Addressing the Need for SPINE Stability Evaluation |
title_sort | radiofrequency ablation in vertebral body metastasis with and without percutaneous cement augmentation: a systematic review addressing the need for spine stability evaluation |
topic | Systematic Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10046948/ https://www.ncbi.nlm.nih.gov/pubmed/36980472 http://dx.doi.org/10.3390/diagnostics13061164 |
work_keys_str_mv | AT colonnastefano radiofrequencyablationinvertebralbodymetastasiswithandwithoutpercutaneouscementaugmentationasystematicreviewaddressingtheneedforspinestabilityevaluation AT bianconiandrea radiofrequencyablationinvertebralbodymetastasiswithandwithoutpercutaneouscementaugmentationasystematicreviewaddressingtheneedforspinestabilityevaluation AT cofanofabio radiofrequencyablationinvertebralbodymetastasiswithandwithoutpercutaneouscementaugmentationasystematicreviewaddressingtheneedforspinestabilityevaluation AT prioralessandro radiofrequencyablationinvertebralbodymetastasiswithandwithoutpercutaneouscementaugmentationasystematicreviewaddressingtheneedforspinestabilityevaluation AT dipernagiuseppe radiofrequencyablationinvertebralbodymetastasiswithandwithoutpercutaneouscementaugmentationasystematicreviewaddressingtheneedforspinestabilityevaluation AT palmierigiuseppe radiofrequencyablationinvertebralbodymetastasiswithandwithoutpercutaneouscementaugmentationasystematicreviewaddressingtheneedforspinestabilityevaluation AT zonagianluigi radiofrequencyablationinvertebralbodymetastasiswithandwithoutpercutaneouscementaugmentationasystematicreviewaddressingtheneedforspinestabilityevaluation AT garbossadiego radiofrequencyablationinvertebralbodymetastasiswithandwithoutpercutaneouscementaugmentationasystematicreviewaddressingtheneedforspinestabilityevaluation AT fiaschipietro radiofrequencyablationinvertebralbodymetastasiswithandwithoutpercutaneouscementaugmentationasystematicreviewaddressingtheneedforspinestabilityevaluation |