Effects of Sepsis on Immune Response, Microbiome and Oxidative Metabolism in Preterm Infants

This is a narrative review about the mechanisms involved in bacterial sepsis in preterm infants, which is an illness with a high incidence, morbidity, and mortality. The role of the innate immune response and its relationship with oxidative stress in the pathogenesis are described as well as their p...

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Autores principales: Parra-Llorca, Anna, Pinilla-Gonzlez, Alejandro, Torrejón-Rodríguez, Laura, Lara-Cantón, Inmaculada, Kuligowski, Julia, Collado, María Carmen, Gormaz, María, Aguar, Marta, Vento, Máximo, Serna, Eva, Cernada, María
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10046958/
https://www.ncbi.nlm.nih.gov/pubmed/36980160
http://dx.doi.org/10.3390/children10030602
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author Parra-Llorca, Anna
Pinilla-Gonzlez, Alejandro
Torrejón-Rodríguez, Laura
Lara-Cantón, Inmaculada
Kuligowski, Julia
Collado, María Carmen
Gormaz, María
Aguar, Marta
Vento, Máximo
Serna, Eva
Cernada, María
author_facet Parra-Llorca, Anna
Pinilla-Gonzlez, Alejandro
Torrejón-Rodríguez, Laura
Lara-Cantón, Inmaculada
Kuligowski, Julia
Collado, María Carmen
Gormaz, María
Aguar, Marta
Vento, Máximo
Serna, Eva
Cernada, María
author_sort Parra-Llorca, Anna
collection PubMed
description This is a narrative review about the mechanisms involved in bacterial sepsis in preterm infants, which is an illness with a high incidence, morbidity, and mortality. The role of the innate immune response and its relationship with oxidative stress in the pathogenesis are described as well as their potential implementation as early biomarkers. Moreover, we address the impact that all the mechanisms triggered by sepsis have on the dysbiosis and the changes on neonatal microbiota.
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spelling pubmed-100469582023-03-29 Effects of Sepsis on Immune Response, Microbiome and Oxidative Metabolism in Preterm Infants Parra-Llorca, Anna Pinilla-Gonzlez, Alejandro Torrejón-Rodríguez, Laura Lara-Cantón, Inmaculada Kuligowski, Julia Collado, María Carmen Gormaz, María Aguar, Marta Vento, Máximo Serna, Eva Cernada, María Children (Basel) Review This is a narrative review about the mechanisms involved in bacterial sepsis in preterm infants, which is an illness with a high incidence, morbidity, and mortality. The role of the innate immune response and its relationship with oxidative stress in the pathogenesis are described as well as their potential implementation as early biomarkers. Moreover, we address the impact that all the mechanisms triggered by sepsis have on the dysbiosis and the changes on neonatal microbiota. MDPI 2023-03-22 /pmc/articles/PMC10046958/ /pubmed/36980160 http://dx.doi.org/10.3390/children10030602 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Parra-Llorca, Anna
Pinilla-Gonzlez, Alejandro
Torrejón-Rodríguez, Laura
Lara-Cantón, Inmaculada
Kuligowski, Julia
Collado, María Carmen
Gormaz, María
Aguar, Marta
Vento, Máximo
Serna, Eva
Cernada, María
Effects of Sepsis on Immune Response, Microbiome and Oxidative Metabolism in Preterm Infants
title Effects of Sepsis on Immune Response, Microbiome and Oxidative Metabolism in Preterm Infants
title_full Effects of Sepsis on Immune Response, Microbiome and Oxidative Metabolism in Preterm Infants
title_fullStr Effects of Sepsis on Immune Response, Microbiome and Oxidative Metabolism in Preterm Infants
title_full_unstemmed Effects of Sepsis on Immune Response, Microbiome and Oxidative Metabolism in Preterm Infants
title_short Effects of Sepsis on Immune Response, Microbiome and Oxidative Metabolism in Preterm Infants
title_sort effects of sepsis on immune response, microbiome and oxidative metabolism in preterm infants
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10046958/
https://www.ncbi.nlm.nih.gov/pubmed/36980160
http://dx.doi.org/10.3390/children10030602
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