Stromal Senescence following Treatment with the CDK4/6 Inhibitor Palbociclib Alters the Lung Metastatic Niche and Increases Metastasis of Drug-Resistant Mammary Cancer Cells

SIMPLE SUMMARY: CDK4/6 inhibitors (CDKis) are a first-line treatment for metastatic hormone-receptor-positive breast cancer, but resistance frequently develops. One potential resistance mechanism could be induction of cellular senescence in non-tumor tissues. The aim of our study was to identify CDK...

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Detalles Bibliográficos
Autores principales: Gallanis, Gregory T., Sharif, Ghada M., Schmidt, Marcel O., Friedland, Benjamin N., Battina, Rohith, Rahhal, Raneen, Davis, John E., Khan, Irfan S., Wellstein, Anton, Riegel, Anna T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10046966/
https://www.ncbi.nlm.nih.gov/pubmed/36980794
http://dx.doi.org/10.3390/cancers15061908

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10046966/
https://www.ncbi.nlm.nih.gov/pubmed/36980794
http://dx.doi.org/10.3390/cancers15061908

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