Non-Oncogene Addiction of KRAS-Mutant Cancers to IL-1β via Versican and Mononuclear IKKβ

SIMPLE SUMMARY: Kirsten rat sarcoma virus (KRAS)-mutant cancers are frequent, metastatic, lethal, and largely undruggable. The aim of this study was to investigate the pathways through which KRAS-mutant cancers foster their growth, thereby unravelling novel therapeutic targets. We show that KRAS-mut...

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Detalles Bibliográficos
Autores principales: Spella, Magda, Ntaliarda, Giannoula, Skiadas, Georgios, Lamort, Anne-Sophie, Vreka, Malamati, Marazioti, Antonia, Lilis, Ioannis, Bouloukou, Eleni, Giotopoulou, Georgia A., Pepe, Mario A. A., Weiss, Stefanie A. I., Petrera, Agnese, Hauck, Stefanie M., Koch, Ina, Lindner, Michael, Hatz, Rudolph A., Behr, Juergen, Arendt, Kristina A. M., Giopanou, Ioanna, Brunn, David, Savai, Rajkumar, Jenne, Dieter E., de Château, Maarten, Yull, Fiona E., Blackwell, Timothy S., Stathopoulos, Georgios T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10047096/
https://www.ncbi.nlm.nih.gov/pubmed/36980752
http://dx.doi.org/10.3390/cancers15061866

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