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Pesticidal Toxicity of Phosphine and Its Interaction with Other Pest Control Treatments

Phosphine is the most widely used fumigant for stored grains due to a lack of better alternatives, all of which have serious shortcomings that restrict their use. The extensive use of phosphine has led to the development of resistance among insect pests of grain, which threatens its status as a reli...

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Autores principales: Alzahrani, Saad M., Ebert, Paul R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10047108/
https://www.ncbi.nlm.nih.gov/pubmed/36975531
http://dx.doi.org/10.3390/cimb45030161
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author Alzahrani, Saad M.
Ebert, Paul R.
author_facet Alzahrani, Saad M.
Ebert, Paul R.
author_sort Alzahrani, Saad M.
collection PubMed
description Phosphine is the most widely used fumigant for stored grains due to a lack of better alternatives, all of which have serious shortcomings that restrict their use. The extensive use of phosphine has led to the development of resistance among insect pests of grain, which threatens its status as a reliable fumigant. Understanding the mode of action of phosphine as well as its resistance mechanisms provides insight that may lead to improved phosphine efficacy and pest control strategies. The mechanisms of action in phosphine vary from disrupting metabolism and oxidative stress to neurotoxicity. Phosphine resistance is genetically inherited and is mediated by the mitochondrial dihydrolipoamide dehydrogenase complex. In this regard, laboratory studies have revealed treatments that synergistically enhance phosphine toxicity that may be used to suppress resistance development and enhance efficacy. Here, we discuss the reported phosphine modes of action, mechanisms of resistance and interactions with other treatments.
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spelling pubmed-100471082023-03-29 Pesticidal Toxicity of Phosphine and Its Interaction with Other Pest Control Treatments Alzahrani, Saad M. Ebert, Paul R. Curr Issues Mol Biol Review Phosphine is the most widely used fumigant for stored grains due to a lack of better alternatives, all of which have serious shortcomings that restrict their use. The extensive use of phosphine has led to the development of resistance among insect pests of grain, which threatens its status as a reliable fumigant. Understanding the mode of action of phosphine as well as its resistance mechanisms provides insight that may lead to improved phosphine efficacy and pest control strategies. The mechanisms of action in phosphine vary from disrupting metabolism and oxidative stress to neurotoxicity. Phosphine resistance is genetically inherited and is mediated by the mitochondrial dihydrolipoamide dehydrogenase complex. In this regard, laboratory studies have revealed treatments that synergistically enhance phosphine toxicity that may be used to suppress resistance development and enhance efficacy. Here, we discuss the reported phosphine modes of action, mechanisms of resistance and interactions with other treatments. MDPI 2023-03-17 /pmc/articles/PMC10047108/ /pubmed/36975531 http://dx.doi.org/10.3390/cimb45030161 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Alzahrani, Saad M.
Ebert, Paul R.
Pesticidal Toxicity of Phosphine and Its Interaction with Other Pest Control Treatments
title Pesticidal Toxicity of Phosphine and Its Interaction with Other Pest Control Treatments
title_full Pesticidal Toxicity of Phosphine and Its Interaction with Other Pest Control Treatments
title_fullStr Pesticidal Toxicity of Phosphine and Its Interaction with Other Pest Control Treatments
title_full_unstemmed Pesticidal Toxicity of Phosphine and Its Interaction with Other Pest Control Treatments
title_short Pesticidal Toxicity of Phosphine and Its Interaction with Other Pest Control Treatments
title_sort pesticidal toxicity of phosphine and its interaction with other pest control treatments
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10047108/
https://www.ncbi.nlm.nih.gov/pubmed/36975531
http://dx.doi.org/10.3390/cimb45030161
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