Autoimmune Polyendocrine Syndromes in the Pediatric Age

Autoimmune polyendocrine syndromes (APSs) encompass a heterogeneous group of rare diseases characterized by autoimmune activity against two or more endocrine or non-endocrine organs. Three types of APSs are reported, including both monogenic and multifactorial, heterogeneous disorders. The aim of th...

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Autores principales: Paparella, Roberto, Menghi, Michela, Micangeli, Ginevra, Leonardi, Lucia, Profeta, Giovanni, Tarani, Francesca, Petrella, Carla, Ferraguti, Giampiero, Fiore, Marco, Tarani, Luigi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10047132/
https://www.ncbi.nlm.nih.gov/pubmed/36980146
http://dx.doi.org/10.3390/children10030588
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author Paparella, Roberto
Menghi, Michela
Micangeli, Ginevra
Leonardi, Lucia
Profeta, Giovanni
Tarani, Francesca
Petrella, Carla
Ferraguti, Giampiero
Fiore, Marco
Tarani, Luigi
author_facet Paparella, Roberto
Menghi, Michela
Micangeli, Ginevra
Leonardi, Lucia
Profeta, Giovanni
Tarani, Francesca
Petrella, Carla
Ferraguti, Giampiero
Fiore, Marco
Tarani, Luigi
author_sort Paparella, Roberto
collection PubMed
description Autoimmune polyendocrine syndromes (APSs) encompass a heterogeneous group of rare diseases characterized by autoimmune activity against two or more endocrine or non-endocrine organs. Three types of APSs are reported, including both monogenic and multifactorial, heterogeneous disorders. The aim of this manuscript is to present the main clinical and epidemiological characteristics of APS-1, APS-2, and IPEX syndrome in the pediatric age, describing the mechanisms of autoimmunity and the currently available treatments for these rare conditions.
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spelling pubmed-100471322023-03-29 Autoimmune Polyendocrine Syndromes in the Pediatric Age Paparella, Roberto Menghi, Michela Micangeli, Ginevra Leonardi, Lucia Profeta, Giovanni Tarani, Francesca Petrella, Carla Ferraguti, Giampiero Fiore, Marco Tarani, Luigi Children (Basel) Review Autoimmune polyendocrine syndromes (APSs) encompass a heterogeneous group of rare diseases characterized by autoimmune activity against two or more endocrine or non-endocrine organs. Three types of APSs are reported, including both monogenic and multifactorial, heterogeneous disorders. The aim of this manuscript is to present the main clinical and epidemiological characteristics of APS-1, APS-2, and IPEX syndrome in the pediatric age, describing the mechanisms of autoimmunity and the currently available treatments for these rare conditions. MDPI 2023-03-19 /pmc/articles/PMC10047132/ /pubmed/36980146 http://dx.doi.org/10.3390/children10030588 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Paparella, Roberto
Menghi, Michela
Micangeli, Ginevra
Leonardi, Lucia
Profeta, Giovanni
Tarani, Francesca
Petrella, Carla
Ferraguti, Giampiero
Fiore, Marco
Tarani, Luigi
Autoimmune Polyendocrine Syndromes in the Pediatric Age
title Autoimmune Polyendocrine Syndromes in the Pediatric Age
title_full Autoimmune Polyendocrine Syndromes in the Pediatric Age
title_fullStr Autoimmune Polyendocrine Syndromes in the Pediatric Age
title_full_unstemmed Autoimmune Polyendocrine Syndromes in the Pediatric Age
title_short Autoimmune Polyendocrine Syndromes in the Pediatric Age
title_sort autoimmune polyendocrine syndromes in the pediatric age
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10047132/
https://www.ncbi.nlm.nih.gov/pubmed/36980146
http://dx.doi.org/10.3390/children10030588
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