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Brain Vascular Health in ALS Is Mediated through Motor Cortex Microvascular Integrity

Brain vascular health appears to be critical for preventing the development of amyotrophic lateral sclerosis (ALS) and slowing its progression. ALS patients often demonstrate cardiovascular risk factors and commonly suffer from cerebrovascular disease, with evidence of pathological alterations in th...

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Autores principales: Schreiber, Stefanie, Bernal, Jose, Arndt, Philipp, Schreiber, Frank, Müller, Patrick, Morton, Lorena, Braun-Dullaeus, Rüdiger Christian, Valdés-Hernández, Maria Del Carmen, Duarte, Roberto, Wardlaw, Joanna Marguerite, Meuth, Sven Günther, Mietzner, Grazia, Vielhaber, Stefan, Dunay, Ildiko Rita, Dityatev, Alexander, Jandke, Solveig, Mattern, Hendrik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10047140/
https://www.ncbi.nlm.nih.gov/pubmed/36980297
http://dx.doi.org/10.3390/cells12060957
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author Schreiber, Stefanie
Bernal, Jose
Arndt, Philipp
Schreiber, Frank
Müller, Patrick
Morton, Lorena
Braun-Dullaeus, Rüdiger Christian
Valdés-Hernández, Maria Del Carmen
Duarte, Roberto
Wardlaw, Joanna Marguerite
Meuth, Sven Günther
Mietzner, Grazia
Vielhaber, Stefan
Dunay, Ildiko Rita
Dityatev, Alexander
Jandke, Solveig
Mattern, Hendrik
author_facet Schreiber, Stefanie
Bernal, Jose
Arndt, Philipp
Schreiber, Frank
Müller, Patrick
Morton, Lorena
Braun-Dullaeus, Rüdiger Christian
Valdés-Hernández, Maria Del Carmen
Duarte, Roberto
Wardlaw, Joanna Marguerite
Meuth, Sven Günther
Mietzner, Grazia
Vielhaber, Stefan
Dunay, Ildiko Rita
Dityatev, Alexander
Jandke, Solveig
Mattern, Hendrik
author_sort Schreiber, Stefanie
collection PubMed
description Brain vascular health appears to be critical for preventing the development of amyotrophic lateral sclerosis (ALS) and slowing its progression. ALS patients often demonstrate cardiovascular risk factors and commonly suffer from cerebrovascular disease, with evidence of pathological alterations in their small cerebral blood vessels. Impaired vascular brain health has detrimental effects on motor neurons: vascular endothelial growth factor levels are lowered in ALS, which can compromise endothelial cell formation and the integrity of the blood–brain barrier. Increased turnover of neurovascular unit cells precedes their senescence, which, together with pericyte alterations, further fosters the failure of toxic metabolite removal. We here provide a comprehensive overview of the pathogenesis of impaired brain vascular health in ALS and how novel magnetic resonance imaging techniques can aid its detection. In particular, we discuss vascular patterns of blood supply to the motor cortex with the number of branches from the anterior and middle cerebral arteries acting as a novel marker of resistance and resilience against downstream effects of vascular risk and events in ALS. We outline how certain interventions adapted to patient needs and capabilities have the potential to mechanistically target the brain microvasculature towards favorable motor cortex blood supply patterns. Through this strategy, we aim to guide novel approaches to ALS management and a better understanding of ALS pathophysiology.
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spelling pubmed-100471402023-03-29 Brain Vascular Health in ALS Is Mediated through Motor Cortex Microvascular Integrity Schreiber, Stefanie Bernal, Jose Arndt, Philipp Schreiber, Frank Müller, Patrick Morton, Lorena Braun-Dullaeus, Rüdiger Christian Valdés-Hernández, Maria Del Carmen Duarte, Roberto Wardlaw, Joanna Marguerite Meuth, Sven Günther Mietzner, Grazia Vielhaber, Stefan Dunay, Ildiko Rita Dityatev, Alexander Jandke, Solveig Mattern, Hendrik Cells Review Brain vascular health appears to be critical for preventing the development of amyotrophic lateral sclerosis (ALS) and slowing its progression. ALS patients often demonstrate cardiovascular risk factors and commonly suffer from cerebrovascular disease, with evidence of pathological alterations in their small cerebral blood vessels. Impaired vascular brain health has detrimental effects on motor neurons: vascular endothelial growth factor levels are lowered in ALS, which can compromise endothelial cell formation and the integrity of the blood–brain barrier. Increased turnover of neurovascular unit cells precedes their senescence, which, together with pericyte alterations, further fosters the failure of toxic metabolite removal. We here provide a comprehensive overview of the pathogenesis of impaired brain vascular health in ALS and how novel magnetic resonance imaging techniques can aid its detection. In particular, we discuss vascular patterns of blood supply to the motor cortex with the number of branches from the anterior and middle cerebral arteries acting as a novel marker of resistance and resilience against downstream effects of vascular risk and events in ALS. We outline how certain interventions adapted to patient needs and capabilities have the potential to mechanistically target the brain microvasculature towards favorable motor cortex blood supply patterns. Through this strategy, we aim to guide novel approaches to ALS management and a better understanding of ALS pathophysiology. MDPI 2023-03-21 /pmc/articles/PMC10047140/ /pubmed/36980297 http://dx.doi.org/10.3390/cells12060957 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Schreiber, Stefanie
Bernal, Jose
Arndt, Philipp
Schreiber, Frank
Müller, Patrick
Morton, Lorena
Braun-Dullaeus, Rüdiger Christian
Valdés-Hernández, Maria Del Carmen
Duarte, Roberto
Wardlaw, Joanna Marguerite
Meuth, Sven Günther
Mietzner, Grazia
Vielhaber, Stefan
Dunay, Ildiko Rita
Dityatev, Alexander
Jandke, Solveig
Mattern, Hendrik
Brain Vascular Health in ALS Is Mediated through Motor Cortex Microvascular Integrity
title Brain Vascular Health in ALS Is Mediated through Motor Cortex Microvascular Integrity
title_full Brain Vascular Health in ALS Is Mediated through Motor Cortex Microvascular Integrity
title_fullStr Brain Vascular Health in ALS Is Mediated through Motor Cortex Microvascular Integrity
title_full_unstemmed Brain Vascular Health in ALS Is Mediated through Motor Cortex Microvascular Integrity
title_short Brain Vascular Health in ALS Is Mediated through Motor Cortex Microvascular Integrity
title_sort brain vascular health in als is mediated through motor cortex microvascular integrity
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10047140/
https://www.ncbi.nlm.nih.gov/pubmed/36980297
http://dx.doi.org/10.3390/cells12060957
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