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Comparison of MAFLD and NAFLD Characteristics in Children

Background & aims: An international panel proposed a diagnostic framework for metabolic-associated fatty liver disease (MAFLD) in children. The aim was to compare the clinical features of MAFLD and nonalcoholic fatty liver disease (NAFLD) in children. Methods: The characteristic differences betw...

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Autores principales: Xing, Yunfei, Fan, Jiangao, Wang, Hai-Jun, Wang, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10047180/
https://www.ncbi.nlm.nih.gov/pubmed/36980118
http://dx.doi.org/10.3390/children10030560
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author Xing, Yunfei
Fan, Jiangao
Wang, Hai-Jun
Wang, Hui
author_facet Xing, Yunfei
Fan, Jiangao
Wang, Hai-Jun
Wang, Hui
author_sort Xing, Yunfei
collection PubMed
description Background & aims: An international panel proposed a diagnostic framework for metabolic-associated fatty liver disease (MAFLD) in children. The aim was to compare the clinical features of MAFLD and nonalcoholic fatty liver disease (NAFLD) in children. Methods: The characteristic differences between NAFLD and MAFLD in children were compared with the National Health and Nutrition Examination Survey (NHANES) 2017–2018 in the U.S. and the Comprehensive Prevention Project for Overweight and Obese Adolescents (CPOOA) study in China. Results: In NHANES 2017–2018, regardless of which criteria were implemented, participants with hepatic steatosis were more likely to have higher BMI z-scores, a higher prevalence of hypertension or higher metabolic indices and higher non-invasive liver fibrosis scores (all p < 0.05). The cases diagnosed by those two definitions had a similarity of over 75%. More obese children were diagnosed with MAFLD than NAFLD (p < 0.001). However, approximately 19% of children with NAFLD present with normal weight and fasting glucose levels and cannot be diagnosed with MAFLD. The CPOOA study excluded viral infected liver disease and certain kinds of congenital causes of liver steatosis patients, resulting in children with NAFLD being identical with MAFLD children. Conclusions: Most clinical features were similar between children with MAFLD and children with NAFLD, and more than 75% of children with NAFLD can also be diagnosed with MAFLD. However, approximately 19% of children with NAFLD cannot be categorized as MAFLD. Therefore, to gain greater benefits from renaming NAFLD to MAFLD in pediatrics, the prevalence of different causes of hepatic steatosis in children needs to be understood.
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spelling pubmed-100471802023-03-29 Comparison of MAFLD and NAFLD Characteristics in Children Xing, Yunfei Fan, Jiangao Wang, Hai-Jun Wang, Hui Children (Basel) Article Background & aims: An international panel proposed a diagnostic framework for metabolic-associated fatty liver disease (MAFLD) in children. The aim was to compare the clinical features of MAFLD and nonalcoholic fatty liver disease (NAFLD) in children. Methods: The characteristic differences between NAFLD and MAFLD in children were compared with the National Health and Nutrition Examination Survey (NHANES) 2017–2018 in the U.S. and the Comprehensive Prevention Project for Overweight and Obese Adolescents (CPOOA) study in China. Results: In NHANES 2017–2018, regardless of which criteria were implemented, participants with hepatic steatosis were more likely to have higher BMI z-scores, a higher prevalence of hypertension or higher metabolic indices and higher non-invasive liver fibrosis scores (all p < 0.05). The cases diagnosed by those two definitions had a similarity of over 75%. More obese children were diagnosed with MAFLD than NAFLD (p < 0.001). However, approximately 19% of children with NAFLD present with normal weight and fasting glucose levels and cannot be diagnosed with MAFLD. The CPOOA study excluded viral infected liver disease and certain kinds of congenital causes of liver steatosis patients, resulting in children with NAFLD being identical with MAFLD children. Conclusions: Most clinical features were similar between children with MAFLD and children with NAFLD, and more than 75% of children with NAFLD can also be diagnosed with MAFLD. However, approximately 19% of children with NAFLD cannot be categorized as MAFLD. Therefore, to gain greater benefits from renaming NAFLD to MAFLD in pediatrics, the prevalence of different causes of hepatic steatosis in children needs to be understood. MDPI 2023-03-16 /pmc/articles/PMC10047180/ /pubmed/36980118 http://dx.doi.org/10.3390/children10030560 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Xing, Yunfei
Fan, Jiangao
Wang, Hai-Jun
Wang, Hui
Comparison of MAFLD and NAFLD Characteristics in Children
title Comparison of MAFLD and NAFLD Characteristics in Children
title_full Comparison of MAFLD and NAFLD Characteristics in Children
title_fullStr Comparison of MAFLD and NAFLD Characteristics in Children
title_full_unstemmed Comparison of MAFLD and NAFLD Characteristics in Children
title_short Comparison of MAFLD and NAFLD Characteristics in Children
title_sort comparison of mafld and nafld characteristics in children
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10047180/
https://www.ncbi.nlm.nih.gov/pubmed/36980118
http://dx.doi.org/10.3390/children10030560
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