Subcellular Epithelial HMGB1 Expression Is Associated with Colorectal Neoplastic Progression, Male Sex, Mismatch Repair Protein Expression, Lymph Node Positivity, and an ‘Immune Cold’ Phenotype Associated with Poor Survival

SIMPLE SUMMARY: New treatment targets are urgently needed for colorectal cancer. Here, we investigate the role of HMGB1—a multifunctional immune protein—in colorectal cancer. We demonstrate dynamic subcellular (nuclear and cytoplasmic) HMGB1 expression in lesions seen throughout different stages of...

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Detalles Bibliográficos
Autores principales: Porter, Ross J., Murray, Graeme I., Hapca, Sandra, Hay, Andrew, Craig, Stephanie G., Humphries, Matthew P., James, Jacqueline A., Salto-Tellez, Manuel, Brice, Daniel P., Berry, Susan H., McLean, Mairi H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10047220/
https://www.ncbi.nlm.nih.gov/pubmed/36980751
http://dx.doi.org/10.3390/cancers15061865

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10047220/
https://www.ncbi.nlm.nih.gov/pubmed/36980751
http://dx.doi.org/10.3390/cancers15061865

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