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Prader–Willi Syndrome and Weight Gain Control: From Prevention to Surgery—A Narrative Review

Severe obesity remains one of the most important symptoms of Prader–Willi Syndrome (PWS), and controlling weight represents a crucial point in the therapeutical approach to the syndrome. We present an overview of different progressive patterns of growth that involve controlling weight in PWS. Mechan...

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Detalles Bibliográficos
Autores principales: Calcaterra, Valeria, Magenes, Vittoria Carlotta, Destro, Francesca, Baldassarre, Paola, Silvestro, Giustino Simone, Tricella, Chiara, Visioli, Alessandro, Verduci, Elvira, Pelizzo, Gloria, Zuccotti, Gianvincenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10047227/
https://www.ncbi.nlm.nih.gov/pubmed/36980122
http://dx.doi.org/10.3390/children10030564
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author Calcaterra, Valeria
Magenes, Vittoria Carlotta
Destro, Francesca
Baldassarre, Paola
Silvestro, Giustino Simone
Tricella, Chiara
Visioli, Alessandro
Verduci, Elvira
Pelizzo, Gloria
Zuccotti, Gianvincenzo
author_facet Calcaterra, Valeria
Magenes, Vittoria Carlotta
Destro, Francesca
Baldassarre, Paola
Silvestro, Giustino Simone
Tricella, Chiara
Visioli, Alessandro
Verduci, Elvira
Pelizzo, Gloria
Zuccotti, Gianvincenzo
author_sort Calcaterra, Valeria
collection PubMed
description Severe obesity remains one of the most important symptoms of Prader–Willi Syndrome (PWS), and controlling weight represents a crucial point in the therapeutical approach to the syndrome. We present an overview of different progressive patterns of growth that involve controlling weight in PWS. Mechanisms involved in the development of obesity and in preventive and therapeutic strategies to control weight gain are discussed. Early diagnosis, a controlled diet regimen, regular physical activity, follow-up by multidisciplinary teams, and hormonal treatment improved the management of excessive weight gain. In selected cases, a surgical approach can be also considered. Controlling weight in PWS remains a challenge for pediatricians. The importance of consulting different healthcare specialists, starting from the neonatal and pediatric age, is also considered as a crucial approach to controlling weight, as well as to limiting and preventing the onset of obesity and its complications.
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spelling pubmed-100472272023-03-29 Prader–Willi Syndrome and Weight Gain Control: From Prevention to Surgery—A Narrative Review Calcaterra, Valeria Magenes, Vittoria Carlotta Destro, Francesca Baldassarre, Paola Silvestro, Giustino Simone Tricella, Chiara Visioli, Alessandro Verduci, Elvira Pelizzo, Gloria Zuccotti, Gianvincenzo Children (Basel) Review Severe obesity remains one of the most important symptoms of Prader–Willi Syndrome (PWS), and controlling weight represents a crucial point in the therapeutical approach to the syndrome. We present an overview of different progressive patterns of growth that involve controlling weight in PWS. Mechanisms involved in the development of obesity and in preventive and therapeutic strategies to control weight gain are discussed. Early diagnosis, a controlled diet regimen, regular physical activity, follow-up by multidisciplinary teams, and hormonal treatment improved the management of excessive weight gain. In selected cases, a surgical approach can be also considered. Controlling weight in PWS remains a challenge for pediatricians. The importance of consulting different healthcare specialists, starting from the neonatal and pediatric age, is also considered as a crucial approach to controlling weight, as well as to limiting and preventing the onset of obesity and its complications. MDPI 2023-03-16 /pmc/articles/PMC10047227/ /pubmed/36980122 http://dx.doi.org/10.3390/children10030564 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Calcaterra, Valeria
Magenes, Vittoria Carlotta
Destro, Francesca
Baldassarre, Paola
Silvestro, Giustino Simone
Tricella, Chiara
Visioli, Alessandro
Verduci, Elvira
Pelizzo, Gloria
Zuccotti, Gianvincenzo
Prader–Willi Syndrome and Weight Gain Control: From Prevention to Surgery—A Narrative Review
title Prader–Willi Syndrome and Weight Gain Control: From Prevention to Surgery—A Narrative Review
title_full Prader–Willi Syndrome and Weight Gain Control: From Prevention to Surgery—A Narrative Review
title_fullStr Prader–Willi Syndrome and Weight Gain Control: From Prevention to Surgery—A Narrative Review
title_full_unstemmed Prader–Willi Syndrome and Weight Gain Control: From Prevention to Surgery—A Narrative Review
title_short Prader–Willi Syndrome and Weight Gain Control: From Prevention to Surgery—A Narrative Review
title_sort prader–willi syndrome and weight gain control: from prevention to surgery—a narrative review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10047227/
https://www.ncbi.nlm.nih.gov/pubmed/36980122
http://dx.doi.org/10.3390/children10030564
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