Reduced Levels of Misfolded and Aggregated Mutant p53 by Proteostatic Activation

In malignant cancer, excessive amounts of mutant p53 often lead to its aggregation, a feature that was recently identified as druggable. Here, we describe that induction of a heat shock-related stress response mediated by Foldlin, a small-molecule tool compound, reduces the protein levels of misfold...

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Detalles Bibliográficos
Autores principales: Naus, Evelyne, Derweduwe, Marleen, Lampi, Youlia, Claeys, Annelies, Pauwels, Jarne, Langenberg, Tobias, Claes, Filip, Xu, Jie, Haemels, Veerle, Atak, Zeynep Kalender, van der Kant, Rob, Van Durme, Joost, De Baets, Greet, Ligon, Keith L., Fiers, Mark, Gevaert, Kris, Aerts, Stein, Rousseau, Frederic, Schymkowitz, Joost, De Smet, Frederik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10047295/
https://www.ncbi.nlm.nih.gov/pubmed/36980299
http://dx.doi.org/10.3390/cells12060960

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