Cargando…

The Pleiotropic Ubiquitin-Specific Peptidase 16 and Its Many Substrates

Ubiquitin-specific peptidase 16 (USP16) is a deubiquitinase that plays a role in the regulation of gene expression, cell cycle progression, and various other functions. It was originally identified as the major deubiquitinase for histone H2A and has since been found to deubiquitinate a range of othe...

Descripción completa

Detalles Bibliográficos
Autores principales: Zheng, Jiahuan, Chen, Chunxu, Guo, Chunqing, Caba, Cody, Tong, Yufeng, Wang, Hengbin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10047310/
https://www.ncbi.nlm.nih.gov/pubmed/36980227
http://dx.doi.org/10.3390/cells12060886
_version_ 1785013888925827072
author Zheng, Jiahuan
Chen, Chunxu
Guo, Chunqing
Caba, Cody
Tong, Yufeng
Wang, Hengbin
author_facet Zheng, Jiahuan
Chen, Chunxu
Guo, Chunqing
Caba, Cody
Tong, Yufeng
Wang, Hengbin
author_sort Zheng, Jiahuan
collection PubMed
description Ubiquitin-specific peptidase 16 (USP16) is a deubiquitinase that plays a role in the regulation of gene expression, cell cycle progression, and various other functions. It was originally identified as the major deubiquitinase for histone H2A and has since been found to deubiquitinate a range of other substrates, including proteins from both the cytoplasm and nucleus. USP16 is phosphorylated when cells enter mitosis and dephosphorylated during the metaphase/anaphase transition. While much of USP16 is localized in the cytoplasm, separating the enzyme from its substrates is considered an important regulatory mechanism. Some of the functions that USP16 has been linked to include DNA damage repair, immune disease, tumorigenesis, protein synthesis, coronary artery health, and male infertility. The strong connection to immune response and the fact that multiple oncogene products are substrates of USP16 suggests that USP16 may be a potential therapeutic target for the treatment of certain human diseases.
format Online
Article
Text
id pubmed-10047310
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-100473102023-03-29 The Pleiotropic Ubiquitin-Specific Peptidase 16 and Its Many Substrates Zheng, Jiahuan Chen, Chunxu Guo, Chunqing Caba, Cody Tong, Yufeng Wang, Hengbin Cells Review Ubiquitin-specific peptidase 16 (USP16) is a deubiquitinase that plays a role in the regulation of gene expression, cell cycle progression, and various other functions. It was originally identified as the major deubiquitinase for histone H2A and has since been found to deubiquitinate a range of other substrates, including proteins from both the cytoplasm and nucleus. USP16 is phosphorylated when cells enter mitosis and dephosphorylated during the metaphase/anaphase transition. While much of USP16 is localized in the cytoplasm, separating the enzyme from its substrates is considered an important regulatory mechanism. Some of the functions that USP16 has been linked to include DNA damage repair, immune disease, tumorigenesis, protein synthesis, coronary artery health, and male infertility. The strong connection to immune response and the fact that multiple oncogene products are substrates of USP16 suggests that USP16 may be a potential therapeutic target for the treatment of certain human diseases. MDPI 2023-03-13 /pmc/articles/PMC10047310/ /pubmed/36980227 http://dx.doi.org/10.3390/cells12060886 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zheng, Jiahuan
Chen, Chunxu
Guo, Chunqing
Caba, Cody
Tong, Yufeng
Wang, Hengbin
The Pleiotropic Ubiquitin-Specific Peptidase 16 and Its Many Substrates
title The Pleiotropic Ubiquitin-Specific Peptidase 16 and Its Many Substrates
title_full The Pleiotropic Ubiquitin-Specific Peptidase 16 and Its Many Substrates
title_fullStr The Pleiotropic Ubiquitin-Specific Peptidase 16 and Its Many Substrates
title_full_unstemmed The Pleiotropic Ubiquitin-Specific Peptidase 16 and Its Many Substrates
title_short The Pleiotropic Ubiquitin-Specific Peptidase 16 and Its Many Substrates
title_sort pleiotropic ubiquitin-specific peptidase 16 and its many substrates
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10047310/
https://www.ncbi.nlm.nih.gov/pubmed/36980227
http://dx.doi.org/10.3390/cells12060886
work_keys_str_mv AT zhengjiahuan thepleiotropicubiquitinspecificpeptidase16anditsmanysubstrates
AT chenchunxu thepleiotropicubiquitinspecificpeptidase16anditsmanysubstrates
AT guochunqing thepleiotropicubiquitinspecificpeptidase16anditsmanysubstrates
AT cabacody thepleiotropicubiquitinspecificpeptidase16anditsmanysubstrates
AT tongyufeng thepleiotropicubiquitinspecificpeptidase16anditsmanysubstrates
AT wanghengbin thepleiotropicubiquitinspecificpeptidase16anditsmanysubstrates
AT zhengjiahuan pleiotropicubiquitinspecificpeptidase16anditsmanysubstrates
AT chenchunxu pleiotropicubiquitinspecificpeptidase16anditsmanysubstrates
AT guochunqing pleiotropicubiquitinspecificpeptidase16anditsmanysubstrates
AT cabacody pleiotropicubiquitinspecificpeptidase16anditsmanysubstrates
AT tongyufeng pleiotropicubiquitinspecificpeptidase16anditsmanysubstrates
AT wanghengbin pleiotropicubiquitinspecificpeptidase16anditsmanysubstrates