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Natural Products for the Treatment of Pulmonary Hypertension: Mechanism, Progress, and Future Opportunities

Pulmonary hypertension (PH) is a lethal disease due to the remodeling of pulmonary vessels. Its pathophysiological characteristics include increased pulmonary arterial pressure and pulmonary vascular resistance, leading to right heart failure and death. The pathological mechanism of PH is complex an...

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Autores principales: Zeng, Zuomei, Wang, Xinyue, Cui, Lidan, Wang, Hongjuan, Guo, Jian, Chen, Yucai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10047369/
https://www.ncbi.nlm.nih.gov/pubmed/36975522
http://dx.doi.org/10.3390/cimb45030152
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author Zeng, Zuomei
Wang, Xinyue
Cui, Lidan
Wang, Hongjuan
Guo, Jian
Chen, Yucai
author_facet Zeng, Zuomei
Wang, Xinyue
Cui, Lidan
Wang, Hongjuan
Guo, Jian
Chen, Yucai
author_sort Zeng, Zuomei
collection PubMed
description Pulmonary hypertension (PH) is a lethal disease due to the remodeling of pulmonary vessels. Its pathophysiological characteristics include increased pulmonary arterial pressure and pulmonary vascular resistance, leading to right heart failure and death. The pathological mechanism of PH is complex and includes inflammation, oxidative stress, vasoconstriction/diastolic imbalance, genetic factors, and ion channel abnormalities. Currently, many clinical drugs for the treatment of PH mainly play their role by relaxing pulmonary arteries, and the treatment effect is limited. Recent studies have shown that various natural products have unique therapeutic advantages for PH with complex pathological mechanisms owing to their multitarget characteristics and low toxicity. This review summarizes the main natural products and their pharmacological mechanisms in PH treatment to provide a useful reference for future research and development of new anti-PH drugs and their mechanisms.
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spelling pubmed-100473692023-03-29 Natural Products for the Treatment of Pulmonary Hypertension: Mechanism, Progress, and Future Opportunities Zeng, Zuomei Wang, Xinyue Cui, Lidan Wang, Hongjuan Guo, Jian Chen, Yucai Curr Issues Mol Biol Review Pulmonary hypertension (PH) is a lethal disease due to the remodeling of pulmonary vessels. Its pathophysiological characteristics include increased pulmonary arterial pressure and pulmonary vascular resistance, leading to right heart failure and death. The pathological mechanism of PH is complex and includes inflammation, oxidative stress, vasoconstriction/diastolic imbalance, genetic factors, and ion channel abnormalities. Currently, many clinical drugs for the treatment of PH mainly play their role by relaxing pulmonary arteries, and the treatment effect is limited. Recent studies have shown that various natural products have unique therapeutic advantages for PH with complex pathological mechanisms owing to their multitarget characteristics and low toxicity. This review summarizes the main natural products and their pharmacological mechanisms in PH treatment to provide a useful reference for future research and development of new anti-PH drugs and their mechanisms. MDPI 2023-03-13 /pmc/articles/PMC10047369/ /pubmed/36975522 http://dx.doi.org/10.3390/cimb45030152 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zeng, Zuomei
Wang, Xinyue
Cui, Lidan
Wang, Hongjuan
Guo, Jian
Chen, Yucai
Natural Products for the Treatment of Pulmonary Hypertension: Mechanism, Progress, and Future Opportunities
title Natural Products for the Treatment of Pulmonary Hypertension: Mechanism, Progress, and Future Opportunities
title_full Natural Products for the Treatment of Pulmonary Hypertension: Mechanism, Progress, and Future Opportunities
title_fullStr Natural Products for the Treatment of Pulmonary Hypertension: Mechanism, Progress, and Future Opportunities
title_full_unstemmed Natural Products for the Treatment of Pulmonary Hypertension: Mechanism, Progress, and Future Opportunities
title_short Natural Products for the Treatment of Pulmonary Hypertension: Mechanism, Progress, and Future Opportunities
title_sort natural products for the treatment of pulmonary hypertension: mechanism, progress, and future opportunities
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10047369/
https://www.ncbi.nlm.nih.gov/pubmed/36975522
http://dx.doi.org/10.3390/cimb45030152
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