COVID-19 and Vasa vasorum: New Atherogenic Factor? A Case Report and Autopsy Findings

Patients with COVID-19 demonstrate higher rates of cardiovascular complications, including thromboses and thromboembolism. One may suppose that the action of SARS-CoV-2 transforms stable atherosclerotic plaques into unstable status. Cardiovascular complications in COVID-19 may be caused by progressi...

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Autores principales: Macarova, Julia A., Malakhova, Sofia A., Novitskaya, Tatiana A., Shapkina, Valeria A., Churilov, Leonid P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10047382/
https://www.ncbi.nlm.nih.gov/pubmed/36980405
http://dx.doi.org/10.3390/diagnostics13061097
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author Macarova, Julia A.
Malakhova, Sofia A.
Novitskaya, Tatiana A.
Shapkina, Valeria A.
Churilov, Leonid P.
author_facet Macarova, Julia A.
Malakhova, Sofia A.
Novitskaya, Tatiana A.
Shapkina, Valeria A.
Churilov, Leonid P.
author_sort Macarova, Julia A.
collection PubMed
description Patients with COVID-19 demonstrate higher rates of cardiovascular complications, including thromboses and thromboembolism. One may suppose that the action of SARS-CoV-2 transforms stable atherosclerotic plaques into unstable status. Cardiovascular complications in COVID-19 may be caused by progressive viral alteration of the blood vessels, including Vasa vasorum. A lethal case of ischemic brain disease caused by cerebral atherosclerosis and exacerbated by a stroke during COVID-19 infection is briefly described. The results of the autopsy showed perivascular lymphocytic infiltration and signs of Vasa vasorum vasculitis with thrombi of adventitial microvasculature. The data discussed in the article are interpreted in the context of the concept giving the important role in atherogenesis to Vasa vasorum.
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spelling pubmed-100473822023-03-29 COVID-19 and Vasa vasorum: New Atherogenic Factor? A Case Report and Autopsy Findings Macarova, Julia A. Malakhova, Sofia A. Novitskaya, Tatiana A. Shapkina, Valeria A. Churilov, Leonid P. Diagnostics (Basel) Case Report Patients with COVID-19 demonstrate higher rates of cardiovascular complications, including thromboses and thromboembolism. One may suppose that the action of SARS-CoV-2 transforms stable atherosclerotic plaques into unstable status. Cardiovascular complications in COVID-19 may be caused by progressive viral alteration of the blood vessels, including Vasa vasorum. A lethal case of ischemic brain disease caused by cerebral atherosclerosis and exacerbated by a stroke during COVID-19 infection is briefly described. The results of the autopsy showed perivascular lymphocytic infiltration and signs of Vasa vasorum vasculitis with thrombi of adventitial microvasculature. The data discussed in the article are interpreted in the context of the concept giving the important role in atherogenesis to Vasa vasorum. MDPI 2023-03-14 /pmc/articles/PMC10047382/ /pubmed/36980405 http://dx.doi.org/10.3390/diagnostics13061097 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Macarova, Julia A.
Malakhova, Sofia A.
Novitskaya, Tatiana A.
Shapkina, Valeria A.
Churilov, Leonid P.
COVID-19 and Vasa vasorum: New Atherogenic Factor? A Case Report and Autopsy Findings
title COVID-19 and Vasa vasorum: New Atherogenic Factor? A Case Report and Autopsy Findings
title_full COVID-19 and Vasa vasorum: New Atherogenic Factor? A Case Report and Autopsy Findings
title_fullStr COVID-19 and Vasa vasorum: New Atherogenic Factor? A Case Report and Autopsy Findings
title_full_unstemmed COVID-19 and Vasa vasorum: New Atherogenic Factor? A Case Report and Autopsy Findings
title_short COVID-19 and Vasa vasorum: New Atherogenic Factor? A Case Report and Autopsy Findings
title_sort covid-19 and vasa vasorum: new atherogenic factor? a case report and autopsy findings
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10047382/
https://www.ncbi.nlm.nih.gov/pubmed/36980405
http://dx.doi.org/10.3390/diagnostics13061097
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