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Synthesis and Physiological Remodeling of CD34 Cells in the Skin following the Reversal of Fibrosis through Intensive Treatment for Lower Limb Lymphedema: A Case Report

A novel type of cell underwent identification between 2005 and 2008 and was denominated the “telocyte” in 2010. In 2012, transmission electron microscopy revealed the presence of telocytes in the dermis. The aim of the present study was to report important changes in immunostained CD34 cells followi...

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Autores principales: Pereira de Godoy, Jose Maria, Pereira de Godoy, Ana Carolina, Guerreiro Godoy, Maria de Fatima, de Santi Neto, Dalisio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10047408/
https://www.ncbi.nlm.nih.gov/pubmed/36975385
http://dx.doi.org/10.3390/dermatopathology10010016
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author Pereira de Godoy, Jose Maria
Pereira de Godoy, Ana Carolina
Guerreiro Godoy, Maria de Fatima
de Santi Neto, Dalisio
author_facet Pereira de Godoy, Jose Maria
Pereira de Godoy, Ana Carolina
Guerreiro Godoy, Maria de Fatima
de Santi Neto, Dalisio
author_sort Pereira de Godoy, Jose Maria
collection PubMed
description A novel type of cell underwent identification between 2005 and 2008 and was denominated the “telocyte” in 2010. In 2012, transmission electron microscopy revealed the presence of telocytes in the dermis. The aim of the present study was to report important changes in immunostained CD34 cells following the treatment of lower limb lymphedema using a specific lymphatic therapy technique. A clinical trial involving the evaluation of changes in immunostained CD34 cells in the epidermis and dermis (10 randomly selected histological fields) of a patient before and after intensive treatment for clinical stage II lymphedema was conducted using the Godoy Method, which was adapted to the treatment of skin fibrosis. The evaluation involved the use of the Weibel multi-point morphometric method. Comparisons were performed using the t-test with a 95% significance level. An important increase in CD34 cells was found with redistribution occurring following treatment. The treatment of primary lymphedema of the lower limbs resulted in the clinical reversal of fibrosis and an increase in the number of immunomarked CD34 cells.
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spelling pubmed-100474082023-03-29 Synthesis and Physiological Remodeling of CD34 Cells in the Skin following the Reversal of Fibrosis through Intensive Treatment for Lower Limb Lymphedema: A Case Report Pereira de Godoy, Jose Maria Pereira de Godoy, Ana Carolina Guerreiro Godoy, Maria de Fatima de Santi Neto, Dalisio Dermatopathology (Basel) Case Report A novel type of cell underwent identification between 2005 and 2008 and was denominated the “telocyte” in 2010. In 2012, transmission electron microscopy revealed the presence of telocytes in the dermis. The aim of the present study was to report important changes in immunostained CD34 cells following the treatment of lower limb lymphedema using a specific lymphatic therapy technique. A clinical trial involving the evaluation of changes in immunostained CD34 cells in the epidermis and dermis (10 randomly selected histological fields) of a patient before and after intensive treatment for clinical stage II lymphedema was conducted using the Godoy Method, which was adapted to the treatment of skin fibrosis. The evaluation involved the use of the Weibel multi-point morphometric method. Comparisons were performed using the t-test with a 95% significance level. An important increase in CD34 cells was found with redistribution occurring following treatment. The treatment of primary lymphedema of the lower limbs resulted in the clinical reversal of fibrosis and an increase in the number of immunomarked CD34 cells. MDPI 2023-03-09 /pmc/articles/PMC10047408/ /pubmed/36975385 http://dx.doi.org/10.3390/dermatopathology10010016 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Pereira de Godoy, Jose Maria
Pereira de Godoy, Ana Carolina
Guerreiro Godoy, Maria de Fatima
de Santi Neto, Dalisio
Synthesis and Physiological Remodeling of CD34 Cells in the Skin following the Reversal of Fibrosis through Intensive Treatment for Lower Limb Lymphedema: A Case Report
title Synthesis and Physiological Remodeling of CD34 Cells in the Skin following the Reversal of Fibrosis through Intensive Treatment for Lower Limb Lymphedema: A Case Report
title_full Synthesis and Physiological Remodeling of CD34 Cells in the Skin following the Reversal of Fibrosis through Intensive Treatment for Lower Limb Lymphedema: A Case Report
title_fullStr Synthesis and Physiological Remodeling of CD34 Cells in the Skin following the Reversal of Fibrosis through Intensive Treatment for Lower Limb Lymphedema: A Case Report
title_full_unstemmed Synthesis and Physiological Remodeling of CD34 Cells in the Skin following the Reversal of Fibrosis through Intensive Treatment for Lower Limb Lymphedema: A Case Report
title_short Synthesis and Physiological Remodeling of CD34 Cells in the Skin following the Reversal of Fibrosis through Intensive Treatment for Lower Limb Lymphedema: A Case Report
title_sort synthesis and physiological remodeling of cd34 cells in the skin following the reversal of fibrosis through intensive treatment for lower limb lymphedema: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10047408/
https://www.ncbi.nlm.nih.gov/pubmed/36975385
http://dx.doi.org/10.3390/dermatopathology10010016
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