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Serum Ferritin Levels in Severe Obstructive Sleep Apnea

Obstructive sleep apnea (OSA) has been associated with various acute and chronic inflammatory diseases, as has serum ferritin, an intracellular iron storage protein. Little is known about the relationship between severity of OSA and serum ferritin levels in otherwise healthy subjects. In this study,...

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Autores principales: Seifen, Christopher, Pordzik, Johannes, Huppertz, Tilman, Hackenberg, Berit, Schupp, Cornelia, Matthias, Christoph, Simon, Perikles, Gouveris, Haralampos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10047524/
https://www.ncbi.nlm.nih.gov/pubmed/36980461
http://dx.doi.org/10.3390/diagnostics13061154
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author Seifen, Christopher
Pordzik, Johannes
Huppertz, Tilman
Hackenberg, Berit
Schupp, Cornelia
Matthias, Christoph
Simon, Perikles
Gouveris, Haralampos
author_facet Seifen, Christopher
Pordzik, Johannes
Huppertz, Tilman
Hackenberg, Berit
Schupp, Cornelia
Matthias, Christoph
Simon, Perikles
Gouveris, Haralampos
author_sort Seifen, Christopher
collection PubMed
description Obstructive sleep apnea (OSA) has been associated with various acute and chronic inflammatory diseases, as has serum ferritin, an intracellular iron storage protein. Little is known about the relationship between severity of OSA and serum ferritin levels in otherwise healthy subjects. In this study, all polysomnographic recordings, serum levels of ferritin, C-reactive protein (CRP), and hemoglobin, as well as patient files from 90 consecutive, otherwise healthy individuals with suspected OSA who presented to a tertiary sleep medical center were retrospectively analyzed. For comparison, three groups were formed based on apnea–hypopnea index (AHI; none or mild OSA: <15/h vs. moderate OSA: 15–30/h vs. severe OSA: >30/h). Serum ferritin levels were significantly positively correlated with AHI (r = 0.3240, p = 0.0020). A clear trend of higher serum ferritin levels was found when patients with severe OSA were compared to those without or with mild OSA. Serum CRP and serum hemoglobin levels did not differ significantly among OSA severity groups. Age and body–mass index (BMI) tended to be higher with increasing OSA severity. The BMI was significant higher in patients with severe OSA compared to those without or with mild (p < 0.001). Therefore, serum ferritin levels may provide a biochemical surrogate marker for OSA severity.
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spelling pubmed-100475242023-03-29 Serum Ferritin Levels in Severe Obstructive Sleep Apnea Seifen, Christopher Pordzik, Johannes Huppertz, Tilman Hackenberg, Berit Schupp, Cornelia Matthias, Christoph Simon, Perikles Gouveris, Haralampos Diagnostics (Basel) Article Obstructive sleep apnea (OSA) has been associated with various acute and chronic inflammatory diseases, as has serum ferritin, an intracellular iron storage protein. Little is known about the relationship between severity of OSA and serum ferritin levels in otherwise healthy subjects. In this study, all polysomnographic recordings, serum levels of ferritin, C-reactive protein (CRP), and hemoglobin, as well as patient files from 90 consecutive, otherwise healthy individuals with suspected OSA who presented to a tertiary sleep medical center were retrospectively analyzed. For comparison, three groups were formed based on apnea–hypopnea index (AHI; none or mild OSA: <15/h vs. moderate OSA: 15–30/h vs. severe OSA: >30/h). Serum ferritin levels were significantly positively correlated with AHI (r = 0.3240, p = 0.0020). A clear trend of higher serum ferritin levels was found when patients with severe OSA were compared to those without or with mild OSA. Serum CRP and serum hemoglobin levels did not differ significantly among OSA severity groups. Age and body–mass index (BMI) tended to be higher with increasing OSA severity. The BMI was significant higher in patients with severe OSA compared to those without or with mild (p < 0.001). Therefore, serum ferritin levels may provide a biochemical surrogate marker for OSA severity. MDPI 2023-03-17 /pmc/articles/PMC10047524/ /pubmed/36980461 http://dx.doi.org/10.3390/diagnostics13061154 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Seifen, Christopher
Pordzik, Johannes
Huppertz, Tilman
Hackenberg, Berit
Schupp, Cornelia
Matthias, Christoph
Simon, Perikles
Gouveris, Haralampos
Serum Ferritin Levels in Severe Obstructive Sleep Apnea
title Serum Ferritin Levels in Severe Obstructive Sleep Apnea
title_full Serum Ferritin Levels in Severe Obstructive Sleep Apnea
title_fullStr Serum Ferritin Levels in Severe Obstructive Sleep Apnea
title_full_unstemmed Serum Ferritin Levels in Severe Obstructive Sleep Apnea
title_short Serum Ferritin Levels in Severe Obstructive Sleep Apnea
title_sort serum ferritin levels in severe obstructive sleep apnea
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10047524/
https://www.ncbi.nlm.nih.gov/pubmed/36980461
http://dx.doi.org/10.3390/diagnostics13061154
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