Multimodal CRISPR perturbations of GWAS loci associated with coronary artery disease in vascular endothelial cells

Genome-wide association studies have identified >250 genetic variants associated with coronary artery disease (CAD), but the causal variants, genes and molecular mechanisms remain unknown at most loci. We performed pooled CRISPR screens to test the impact of sequences at or near CAD-associated ge...

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Detalles Bibliográficos
Autores principales: Wünnemann, Florian, Fotsing Tadjo, Thierry, Beaudoin, Mélissa, Lalonde, Simon, Lo, Ken Sin, Kleinstiver, Benjamin P., Lettre, Guillaume
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10047545/
https://www.ncbi.nlm.nih.gov/pubmed/36928188
http://dx.doi.org/10.1371/journal.pgen.1010680

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10047545/
https://www.ncbi.nlm.nih.gov/pubmed/36928188
http://dx.doi.org/10.1371/journal.pgen.1010680

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