Cargando…

Multimodal CRISPR perturbations of GWAS loci associated with coronary artery disease in vascular endothelial cells

Genome-wide association studies have identified >250 genetic variants associated with coronary artery disease (CAD), but the causal variants, genes and molecular mechanisms remain unknown at most loci. We performed pooled CRISPR screens to test the impact of sequences at or near CAD-associated ge...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wünnemann, Florian, Fotsing Tadjo, Thierry, Beaudoin, Mélissa, Lalonde, Simon, Lo, Ken Sin, Kleinstiver, Benjamin P., Lettre, Guillaume
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10047545/ https://www.ncbi.nlm.nih.gov/pubmed/36928188 http://dx.doi.org/10.1371/journal.pgen.1010680

Ejemplares similares

PHACTR1 splicing isoforms and eQTLs in atherosclerosis-relevant human cells
por: Codina-Fauteux, Valérie-Anne, et al.
Publicado: (2018)

Validation of Genome-Wide Polygenic Risk Scores for Coronary Artery Disease in French Canadians
por: Wünnemann, Florian, et al.
Publicado: (2019)

Integrative analysis of vascular endothelial cell genomic features identifies AIDA as a coronary artery disease candidate gene
por: Lalonde, Simon, et al.
Publicado: (2019)

Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease
por: Rivas, Manuel A., et al.
Publicado: (2011)

Lessons and Implications from Genome-Wide Association Studies (GWAS) Findings of Blood Cell Phenotypes
por: Chami, Nathalie, et al.
Publicado: (2014)

Deep Resequencing of GWAS Loci Identifies Rare Variants in CARD9, IL23R and RNF186 That Are Associated with Ulcerative Colitis
por: Beaudoin, Mélissa, et al.
Publicado: (2013)

The Contribution of GWAS Loci in Familial Dyslipidemias
por: Ripatti, Pietari, et al.
Publicado: (2016)

Human genetic variation alters CRISPR-Cas9 on- and off-targeting specificity at therapeutically implicated loci
por: Lessard, Samuel, et al.
Publicado: (2017)

Quantifying Missing Heritability at Known GWAS Loci
por: Gusev, Alexander, et al.
Publicado: (2013)

GWAS reveals loci associated with velopharyngeal dysfunction
por: Chernus, Jonathan, et al.
Publicado: (2018)

Functional screens refine height GWAS loci
por: Ackert-Bicknell, Cheryl L.
Publicado: (2023)

Optimus Primer: A PCR enrichment primer design program for next-generation sequencing of human exonic regions
por: Brown, Andrew MK, et al.
Publicado: (2010)

Translating GWAS-identified loci for cardiac rhythm and rate using an in vivo image- and CRISPR/Cas9-based approach
por: von der Heyde, Benedikt, et al.
Publicado: (2020)

Genome-wide CRISPR screening of chondrocyte maturation newly implicates genes in skeletal growth and height-associated GWAS loci
por: Baronas, John M., et al.
Publicado: (2023)

GWAS identifies four novel eosinophilic esophagitis loci
por: Sleiman, Patrick MA, et al.
Publicado: (2014)

Using Gene Expression to Annotate Cardiovascular GWAS Loci
por: Heinig, Matthias
Publicado: (2018)

Meta-GWAS for quantitative trait loci identification in soybean
por: Shook, Johnathon M, et al.
Publicado: (2021)

Exploiting the GTEx resources to decipher the mechanisms at GWAS loci
por: Barbeira, Alvaro N., et al.
Publicado: (2021)

Identifying loci with breeding potential across temperate and tropical adaptation via EigenGWAS and EnvGWAS
por: Li, Jing, et al.
Publicado: (2019)

GWAS reveal novel IgA nephropathy risk loci
por: Foo, Jia Nee, et al.
Publicado: (2015)

Investigating the GWAS-Implicated Loci for Rheumatoid Arthritis in the Pakistani Population
por: Aslam, Muhammad Muaaz, et al.
Publicado: (2020)

The Role of Rare Coding Variants in Parkinson's Disease GWAS Loci
por: Germer, Elisabeth Luisa, et al.
Publicado: (2019)

Diversity and microevolution of CRISPR loci in Helicobacter cinaedi
por: Tomida, Junko, et al.
Publicado: (2017)

SNP-Target Genes Interaction Perturbing the Cancer Risk in the Post-GWAS
por: Yang, Wenmin, et al.
Publicado: (2022)

Comparison of DNA methylation profiles in human fetal and adult red blood cell progenitors
por: Lessard, Samuel, et al.
Publicado: (2015)

Association of eGFR-Related Loci Identified by GWAS with Incident CKD and ESRD
por: Böger, Carsten A., et al.
Publicado: (2011)

Frameshift indels introduced by genome editing can lead to in-frame exon skipping
por: Lalonde, Simon, et al.
Publicado: (2017)

Connecting SNPs in Diabetes: A Spatial Analysis of Meta-GWAS Loci
por: Schierding, William, et al.
Publicado: (2015)

Evaluating the Performance of Fine-Mapping Strategies at Common Variant GWAS Loci
por: van de Bunt, Martijn, et al.
Publicado: (2015)

Unravelling the Roles of Susceptibility Loci for Autoimmune Diseases in the Post-GWAS Era
por: Ye, Jody, et al.
Publicado: (2018)

The Application of Multi-Locus GWAS for the Detection of Salt-Tolerance Loci in Rice
por: Cui, Yanru, et al.
Publicado: (2018)

Validation of Susceptibility Loci for Vitiligo Identified by GWAS in the Chinese Han Population
por: Cheng, Lu, et al.
Publicado: (2020)

GWAS loci associated with Chagas cardiomyopathy influences DNA methylation levels
por: Casares-Marfil, Desiré, et al.
Publicado: (2021)

Single-Cell Epigenomics and Functional Fine-Mapping of Atherosclerosis GWAS Loci
por: Örd, Tiit, et al.
Publicado: (2021)

Deep resequencing identifies candidate functional genes in leprosy GWAS loci
por: Fava, Vinicius M., et al.
Publicado: (2021)

Systematic visualisation of molecular QTLs reveals variant mechanisms at GWAS loci
por: Kerimov, Nurlan, et al.
Publicado: (2023)

Re-sequencing Expands Our Understanding of the Phenotypic Impact of Variants at GWAS Loci
por: Service, Susan K., et al.
Publicado: (2014)

Genetic Susceptibility to Vitiligo: GWAS Approaches for Identifying Vitiligo Susceptibility Genes and Loci
por: Shen, Changbing, et al.
Publicado: (2016)

In-Silico Analysis of Inflammatory Bowel Disease (IBD) GWAS Loci to Novel Connections
por: Mesbah-Uddin, Md., et al.
Publicado: (2015)

GWAS identifies 14 loci for device-measured physical activity and sleep duration
por: Doherty, Aiden, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_28esojed44mtqdevu8rdg2jn3u