Cargando…

Alcoholic Liver Disease-Related Hepatocellular Carcinoma: Characteristics and Comparison to General Slovak Hepatocellular Cancer Population

Hepatocellular carcinoma (HCC) has multiple molecular classes that are associated with distinct etiologies and, besides particular molecular characteristics, that also differ in clinical aspects. We aim to characterize the clinical aspects of alcoholic liver disease-related HCC by a retrospective ob...

Descripción completa

Detalles Bibliográficos
Autores principales: Šafčák, Dominik, Dražilová, Sylvia, Gazda, Jakub, Andrašina, Igor, Adamcová-Selčanová, Svetlana, Barila, Radovan, Mego, Michal, Rác, Marek, Skladaný, Ľubomír, Žigrai, Miroslav, Janičko, Martin, Jarčuška, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10047624/
https://www.ncbi.nlm.nih.gov/pubmed/36975484
http://dx.doi.org/10.3390/curroncol30030271
_version_ 1785013972119846912
author Šafčák, Dominik
Dražilová, Sylvia
Gazda, Jakub
Andrašina, Igor
Adamcová-Selčanová, Svetlana
Barila, Radovan
Mego, Michal
Rác, Marek
Skladaný, Ľubomír
Žigrai, Miroslav
Janičko, Martin
Jarčuška, Peter
author_facet Šafčák, Dominik
Dražilová, Sylvia
Gazda, Jakub
Andrašina, Igor
Adamcová-Selčanová, Svetlana
Barila, Radovan
Mego, Michal
Rác, Marek
Skladaný, Ľubomír
Žigrai, Miroslav
Janičko, Martin
Jarčuška, Peter
author_sort Šafčák, Dominik
collection PubMed
description Hepatocellular carcinoma (HCC) has multiple molecular classes that are associated with distinct etiologies and, besides particular molecular characteristics, that also differ in clinical aspects. We aim to characterize the clinical aspects of alcoholic liver disease-related HCC by a retrospective observational study that included all consequent patients diagnosed with MRI or histologically verified HCC in participating centers from 2010 to 2016. A total of 429 patients were included in the analysis, of which 412 patients (96%) had cirrhosis at the time of diagnosis. The most common etiologies were alcoholic liver disease (ALD) (48.3%), chronic hepatitis C (14.9%), NAFLD (12.6%), and chronic hepatitis B (10%). Patients with ALD-related HCC were more commonly males, more commonly had cirrhosis that was in more advanced stages, and had poorer performance status. Despite these results, no differences were observed in the overall (median 8.1 vs. 8.5 months) and progression-free survival (median 4.9 vs. 5.7 months). ALD-HCC patients within BCLC stage 0–A less frequently received potentially curative treatment as compared to the control HCC patients (62.2% vs. 87.5%, p = 0.017); and in patients with ALD-HCC liver function (MELD score) seemed to have a stronger influence on the prognosis compared to the control group HCC. Systemic inflammatory indexes were strongly associated with survival in the whole cohort. In conclusion, alcoholic liver disease is the most common cause of hepatocellular carcinoma in Slovakia, accounting for almost 50% of cases; and patients with ALD-related HCC more commonly had cirrhosis that was in more advanced stages and had poorer performance status, although no difference in survival between ALD-related and other etiology-related HCC was observed.
format Online
Article
Text
id pubmed-10047624
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-100476242023-03-29 Alcoholic Liver Disease-Related Hepatocellular Carcinoma: Characteristics and Comparison to General Slovak Hepatocellular Cancer Population Šafčák, Dominik Dražilová, Sylvia Gazda, Jakub Andrašina, Igor Adamcová-Selčanová, Svetlana Barila, Radovan Mego, Michal Rác, Marek Skladaný, Ľubomír Žigrai, Miroslav Janičko, Martin Jarčuška, Peter Curr Oncol Article Hepatocellular carcinoma (HCC) has multiple molecular classes that are associated with distinct etiologies and, besides particular molecular characteristics, that also differ in clinical aspects. We aim to characterize the clinical aspects of alcoholic liver disease-related HCC by a retrospective observational study that included all consequent patients diagnosed with MRI or histologically verified HCC in participating centers from 2010 to 2016. A total of 429 patients were included in the analysis, of which 412 patients (96%) had cirrhosis at the time of diagnosis. The most common etiologies were alcoholic liver disease (ALD) (48.3%), chronic hepatitis C (14.9%), NAFLD (12.6%), and chronic hepatitis B (10%). Patients with ALD-related HCC were more commonly males, more commonly had cirrhosis that was in more advanced stages, and had poorer performance status. Despite these results, no differences were observed in the overall (median 8.1 vs. 8.5 months) and progression-free survival (median 4.9 vs. 5.7 months). ALD-HCC patients within BCLC stage 0–A less frequently received potentially curative treatment as compared to the control HCC patients (62.2% vs. 87.5%, p = 0.017); and in patients with ALD-HCC liver function (MELD score) seemed to have a stronger influence on the prognosis compared to the control group HCC. Systemic inflammatory indexes were strongly associated with survival in the whole cohort. In conclusion, alcoholic liver disease is the most common cause of hepatocellular carcinoma in Slovakia, accounting for almost 50% of cases; and patients with ALD-related HCC more commonly had cirrhosis that was in more advanced stages and had poorer performance status, although no difference in survival between ALD-related and other etiology-related HCC was observed. MDPI 2023-03-22 /pmc/articles/PMC10047624/ /pubmed/36975484 http://dx.doi.org/10.3390/curroncol30030271 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Šafčák, Dominik
Dražilová, Sylvia
Gazda, Jakub
Andrašina, Igor
Adamcová-Selčanová, Svetlana
Barila, Radovan
Mego, Michal
Rác, Marek
Skladaný, Ľubomír
Žigrai, Miroslav
Janičko, Martin
Jarčuška, Peter
Alcoholic Liver Disease-Related Hepatocellular Carcinoma: Characteristics and Comparison to General Slovak Hepatocellular Cancer Population
title Alcoholic Liver Disease-Related Hepatocellular Carcinoma: Characteristics and Comparison to General Slovak Hepatocellular Cancer Population
title_full Alcoholic Liver Disease-Related Hepatocellular Carcinoma: Characteristics and Comparison to General Slovak Hepatocellular Cancer Population
title_fullStr Alcoholic Liver Disease-Related Hepatocellular Carcinoma: Characteristics and Comparison to General Slovak Hepatocellular Cancer Population
title_full_unstemmed Alcoholic Liver Disease-Related Hepatocellular Carcinoma: Characteristics and Comparison to General Slovak Hepatocellular Cancer Population
title_short Alcoholic Liver Disease-Related Hepatocellular Carcinoma: Characteristics and Comparison to General Slovak Hepatocellular Cancer Population
title_sort alcoholic liver disease-related hepatocellular carcinoma: characteristics and comparison to general slovak hepatocellular cancer population
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10047624/
https://www.ncbi.nlm.nih.gov/pubmed/36975484
http://dx.doi.org/10.3390/curroncol30030271
work_keys_str_mv AT safcakdominik alcoholicliverdiseaserelatedhepatocellularcarcinomacharacteristicsandcomparisontogeneralslovakhepatocellularcancerpopulation
AT drazilovasylvia alcoholicliverdiseaserelatedhepatocellularcarcinomacharacteristicsandcomparisontogeneralslovakhepatocellularcancerpopulation
AT gazdajakub alcoholicliverdiseaserelatedhepatocellularcarcinomacharacteristicsandcomparisontogeneralslovakhepatocellularcancerpopulation
AT andrasinaigor alcoholicliverdiseaserelatedhepatocellularcarcinomacharacteristicsandcomparisontogeneralslovakhepatocellularcancerpopulation
AT adamcovaselcanovasvetlana alcoholicliverdiseaserelatedhepatocellularcarcinomacharacteristicsandcomparisontogeneralslovakhepatocellularcancerpopulation
AT barilaradovan alcoholicliverdiseaserelatedhepatocellularcarcinomacharacteristicsandcomparisontogeneralslovakhepatocellularcancerpopulation
AT megomichal alcoholicliverdiseaserelatedhepatocellularcarcinomacharacteristicsandcomparisontogeneralslovakhepatocellularcancerpopulation
AT racmarek alcoholicliverdiseaserelatedhepatocellularcarcinomacharacteristicsandcomparisontogeneralslovakhepatocellularcancerpopulation
AT skladanylubomir alcoholicliverdiseaserelatedhepatocellularcarcinomacharacteristicsandcomparisontogeneralslovakhepatocellularcancerpopulation
AT zigraimiroslav alcoholicliverdiseaserelatedhepatocellularcarcinomacharacteristicsandcomparisontogeneralslovakhepatocellularcancerpopulation
AT janickomartin alcoholicliverdiseaserelatedhepatocellularcarcinomacharacteristicsandcomparisontogeneralslovakhepatocellularcancerpopulation
AT jarcuskapeter alcoholicliverdiseaserelatedhepatocellularcarcinomacharacteristicsandcomparisontogeneralslovakhepatocellularcancerpopulation