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Ductal Hyperkeratinization and Acinar Renewal Abnormality: New Concepts on Pathogenesis of Meibomian Gland Dysfunction
Meibomian gland dysfunction (MGD) is a functional and morphological disorder of the meibomian glands which results in qualitative or quantitative alteration in meibum secretion and is the major cause of evaporative dry eye (EDE). EDE is often characterized by tear film instability, increased evapora...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10047716/ https://www.ncbi.nlm.nih.gov/pubmed/36975492 http://dx.doi.org/10.3390/cimb45030122 |
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author | Du, Ya-Li Peng, Xi Liu, Yang Wang, Jia-Song Ye, You-Fan Xu, Kang-Kang Qu, Jing-Yu Chen, Hua Xie, Hua-Tao Zhang, Ming-Chang |
author_facet | Du, Ya-Li Peng, Xi Liu, Yang Wang, Jia-Song Ye, You-Fan Xu, Kang-Kang Qu, Jing-Yu Chen, Hua Xie, Hua-Tao Zhang, Ming-Chang |
author_sort | Du, Ya-Li |
collection | PubMed |
description | Meibomian gland dysfunction (MGD) is a functional and morphological disorder of the meibomian glands which results in qualitative or quantitative alteration in meibum secretion and is the major cause of evaporative dry eye (EDE). EDE is often characterized by tear film instability, increased evaporation, hyperosmolarity, inflammation, and ocular surface disorder. The precise pathogenesis of MGD remains elusive. It has been widely considered that MGD develops as a result of ductal epithelial hyperkeratinization, which obstructs the meibomian orifice, halts meibum secretion, and causes secondary acinar atrophy and gland dropout. Abnormal self-renewal and differentiation of the acinar cells also play a significant role in MGD. This review summarizes the latest research findings regarding the possible pathogenesis of MGD and provides further treatment strategies for MGD-EDE patients. |
format | Online Article Text |
id | pubmed-10047716 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100477162023-03-29 Ductal Hyperkeratinization and Acinar Renewal Abnormality: New Concepts on Pathogenesis of Meibomian Gland Dysfunction Du, Ya-Li Peng, Xi Liu, Yang Wang, Jia-Song Ye, You-Fan Xu, Kang-Kang Qu, Jing-Yu Chen, Hua Xie, Hua-Tao Zhang, Ming-Chang Curr Issues Mol Biol Perspective Meibomian gland dysfunction (MGD) is a functional and morphological disorder of the meibomian glands which results in qualitative or quantitative alteration in meibum secretion and is the major cause of evaporative dry eye (EDE). EDE is often characterized by tear film instability, increased evaporation, hyperosmolarity, inflammation, and ocular surface disorder. The precise pathogenesis of MGD remains elusive. It has been widely considered that MGD develops as a result of ductal epithelial hyperkeratinization, which obstructs the meibomian orifice, halts meibum secretion, and causes secondary acinar atrophy and gland dropout. Abnormal self-renewal and differentiation of the acinar cells also play a significant role in MGD. This review summarizes the latest research findings regarding the possible pathogenesis of MGD and provides further treatment strategies for MGD-EDE patients. MDPI 2023-02-27 /pmc/articles/PMC10047716/ /pubmed/36975492 http://dx.doi.org/10.3390/cimb45030122 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Perspective Du, Ya-Li Peng, Xi Liu, Yang Wang, Jia-Song Ye, You-Fan Xu, Kang-Kang Qu, Jing-Yu Chen, Hua Xie, Hua-Tao Zhang, Ming-Chang Ductal Hyperkeratinization and Acinar Renewal Abnormality: New Concepts on Pathogenesis of Meibomian Gland Dysfunction |
title | Ductal Hyperkeratinization and Acinar Renewal Abnormality: New Concepts on Pathogenesis of Meibomian Gland Dysfunction |
title_full | Ductal Hyperkeratinization and Acinar Renewal Abnormality: New Concepts on Pathogenesis of Meibomian Gland Dysfunction |
title_fullStr | Ductal Hyperkeratinization and Acinar Renewal Abnormality: New Concepts on Pathogenesis of Meibomian Gland Dysfunction |
title_full_unstemmed | Ductal Hyperkeratinization and Acinar Renewal Abnormality: New Concepts on Pathogenesis of Meibomian Gland Dysfunction |
title_short | Ductal Hyperkeratinization and Acinar Renewal Abnormality: New Concepts on Pathogenesis of Meibomian Gland Dysfunction |
title_sort | ductal hyperkeratinization and acinar renewal abnormality: new concepts on pathogenesis of meibomian gland dysfunction |
topic | Perspective |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10047716/ https://www.ncbi.nlm.nih.gov/pubmed/36975492 http://dx.doi.org/10.3390/cimb45030122 |
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