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Clear-Cell Mesothelioma of Uterine Corpus: Diagnostic Challenges in Intraoperative Frozen Sections

The clear-cell variant of epithelioid mesothelioma is an extremely rare neoplasm of the peritoneum. It shares histomorphologic features overlapping with a wide variety of tumors including carcinomas and other non-epithelial neoplasms. The diagnosis of peritoneal clear-cell mesothelioma is not always...

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Autores principales: Pongsuvareeyakul, Tip, Saipattranusorn, Kanokkan, Sukpan, Kornkanok, Suprasert, Prapaporn, Khunamornpong, Surapan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10047779/
https://www.ncbi.nlm.nih.gov/pubmed/36980427
http://dx.doi.org/10.3390/diagnostics13061119
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author Pongsuvareeyakul, Tip
Saipattranusorn, Kanokkan
Sukpan, Kornkanok
Suprasert, Prapaporn
Khunamornpong, Surapan
author_facet Pongsuvareeyakul, Tip
Saipattranusorn, Kanokkan
Sukpan, Kornkanok
Suprasert, Prapaporn
Khunamornpong, Surapan
author_sort Pongsuvareeyakul, Tip
collection PubMed
description The clear-cell variant of epithelioid mesothelioma is an extremely rare neoplasm of the peritoneum. It shares histomorphologic features overlapping with a wide variety of tumors including carcinomas and other non-epithelial neoplasms. The diagnosis of peritoneal clear-cell mesothelioma is not always straightforward, despite known immunohistochemistry (IHC) markers. Due to its rarity, this entity may be diagnostically confused with other clear-cell neoplasms, particularly in intraoperative frozen sections. Here, we present a case of clear-cell mesothelioma originating in the uterine serosa that was initially misdiagnosed as clear-cell adenocarcinoma in the intraoperative frozen section. Microscopically, the tumor showed diffuse tubulocystic spaces of variable size lined by clear cells with moderate nuclear atypia. Immunohistochemical staining confirmed the diagnosis of clear-cell mesothelioma. Recognition of this entity, albeit rare, is important as the diagnosis may significantly affect the management considerations. The judicious use of an IHC panel helps to distinguish this tumor from other mimickers.
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spelling pubmed-100477792023-03-29 Clear-Cell Mesothelioma of Uterine Corpus: Diagnostic Challenges in Intraoperative Frozen Sections Pongsuvareeyakul, Tip Saipattranusorn, Kanokkan Sukpan, Kornkanok Suprasert, Prapaporn Khunamornpong, Surapan Diagnostics (Basel) Interesting Images The clear-cell variant of epithelioid mesothelioma is an extremely rare neoplasm of the peritoneum. It shares histomorphologic features overlapping with a wide variety of tumors including carcinomas and other non-epithelial neoplasms. The diagnosis of peritoneal clear-cell mesothelioma is not always straightforward, despite known immunohistochemistry (IHC) markers. Due to its rarity, this entity may be diagnostically confused with other clear-cell neoplasms, particularly in intraoperative frozen sections. Here, we present a case of clear-cell mesothelioma originating in the uterine serosa that was initially misdiagnosed as clear-cell adenocarcinoma in the intraoperative frozen section. Microscopically, the tumor showed diffuse tubulocystic spaces of variable size lined by clear cells with moderate nuclear atypia. Immunohistochemical staining confirmed the diagnosis of clear-cell mesothelioma. Recognition of this entity, albeit rare, is important as the diagnosis may significantly affect the management considerations. The judicious use of an IHC panel helps to distinguish this tumor from other mimickers. MDPI 2023-03-15 /pmc/articles/PMC10047779/ /pubmed/36980427 http://dx.doi.org/10.3390/diagnostics13061119 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Interesting Images
Pongsuvareeyakul, Tip
Saipattranusorn, Kanokkan
Sukpan, Kornkanok
Suprasert, Prapaporn
Khunamornpong, Surapan
Clear-Cell Mesothelioma of Uterine Corpus: Diagnostic Challenges in Intraoperative Frozen Sections
title Clear-Cell Mesothelioma of Uterine Corpus: Diagnostic Challenges in Intraoperative Frozen Sections
title_full Clear-Cell Mesothelioma of Uterine Corpus: Diagnostic Challenges in Intraoperative Frozen Sections
title_fullStr Clear-Cell Mesothelioma of Uterine Corpus: Diagnostic Challenges in Intraoperative Frozen Sections
title_full_unstemmed Clear-Cell Mesothelioma of Uterine Corpus: Diagnostic Challenges in Intraoperative Frozen Sections
title_short Clear-Cell Mesothelioma of Uterine Corpus: Diagnostic Challenges in Intraoperative Frozen Sections
title_sort clear-cell mesothelioma of uterine corpus: diagnostic challenges in intraoperative frozen sections
topic Interesting Images
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10047779/
https://www.ncbi.nlm.nih.gov/pubmed/36980427
http://dx.doi.org/10.3390/diagnostics13061119
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