Exon-18-EGFR Mutated Transformed Small-Cell Lung Cancer: A Case Report and Literature Review

Small-cell lung cancer (SCLC) transformation from EGFR mutant adenocarcinoma is a rare entity that is considered to be a new phenotype of SCLC. While transformation from adenocarcinoma (ADC) with EGFR exon 19 deletions and exon 21 L858R point mutations has been described, to our knowledge, no cases...

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Autores principales: Digiacomo, Nunzio, De Pas, Tommaso, Rossi, Giovanna, Bossi, Paola, Stucchi, Erika, Conforti, Fabio, Cocorocchio, Emilia, Laszlo, Daniele, Pala, Laura, Zattarin, Emma, Catania, Chiara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10047844/
https://www.ncbi.nlm.nih.gov/pubmed/36975478
http://dx.doi.org/10.3390/curroncol30030265
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author Digiacomo, Nunzio
De Pas, Tommaso
Rossi, Giovanna
Bossi, Paola
Stucchi, Erika
Conforti, Fabio
Cocorocchio, Emilia
Laszlo, Daniele
Pala, Laura
Zattarin, Emma
Catania, Chiara
author_facet Digiacomo, Nunzio
De Pas, Tommaso
Rossi, Giovanna
Bossi, Paola
Stucchi, Erika
Conforti, Fabio
Cocorocchio, Emilia
Laszlo, Daniele
Pala, Laura
Zattarin, Emma
Catania, Chiara
author_sort Digiacomo, Nunzio
collection PubMed
description Small-cell lung cancer (SCLC) transformation from EGFR mutant adenocarcinoma is a rare entity that is considered to be a new phenotype of SCLC. While transformation from adenocarcinoma (ADC) with EGFR exon 19 deletions and exon 21 L858R point mutations has been described, to our knowledge, no cases of transformation to SCLC from exon-18-mutated ADC have been reported. We reported a clinical case of a patient with exon-18-EGFR-transformed SCLC, and we performed a systematic review of the literature.
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spelling pubmed-100478442023-03-29 Exon-18-EGFR Mutated Transformed Small-Cell Lung Cancer: A Case Report and Literature Review Digiacomo, Nunzio De Pas, Tommaso Rossi, Giovanna Bossi, Paola Stucchi, Erika Conforti, Fabio Cocorocchio, Emilia Laszlo, Daniele Pala, Laura Zattarin, Emma Catania, Chiara Curr Oncol Case Report Small-cell lung cancer (SCLC) transformation from EGFR mutant adenocarcinoma is a rare entity that is considered to be a new phenotype of SCLC. While transformation from adenocarcinoma (ADC) with EGFR exon 19 deletions and exon 21 L858R point mutations has been described, to our knowledge, no cases of transformation to SCLC from exon-18-mutated ADC have been reported. We reported a clinical case of a patient with exon-18-EGFR-transformed SCLC, and we performed a systematic review of the literature. MDPI 2023-03-20 /pmc/articles/PMC10047844/ /pubmed/36975478 http://dx.doi.org/10.3390/curroncol30030265 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Digiacomo, Nunzio
De Pas, Tommaso
Rossi, Giovanna
Bossi, Paola
Stucchi, Erika
Conforti, Fabio
Cocorocchio, Emilia
Laszlo, Daniele
Pala, Laura
Zattarin, Emma
Catania, Chiara
Exon-18-EGFR Mutated Transformed Small-Cell Lung Cancer: A Case Report and Literature Review
title Exon-18-EGFR Mutated Transformed Small-Cell Lung Cancer: A Case Report and Literature Review
title_full Exon-18-EGFR Mutated Transformed Small-Cell Lung Cancer: A Case Report and Literature Review
title_fullStr Exon-18-EGFR Mutated Transformed Small-Cell Lung Cancer: A Case Report and Literature Review
title_full_unstemmed Exon-18-EGFR Mutated Transformed Small-Cell Lung Cancer: A Case Report and Literature Review
title_short Exon-18-EGFR Mutated Transformed Small-Cell Lung Cancer: A Case Report and Literature Review
title_sort exon-18-egfr mutated transformed small-cell lung cancer: a case report and literature review
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10047844/
https://www.ncbi.nlm.nih.gov/pubmed/36975478
http://dx.doi.org/10.3390/curroncol30030265
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