Cargando…
PET Imaging of Neuro-Inflammation with Tracers Targeting the Translocator Protein (TSPO), a Systematic Review: From Bench to Bedside
Parkinson’s disease is the second most common neurodegenerative disorder, affecting 2–3% of the population of patients >65 years. Although the standard diagnosis of PD is clinical, neuroimaging plays a key role in the evaluation of patients who present symptoms related to neurodegenerative disord...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10047854/ https://www.ncbi.nlm.nih.gov/pubmed/36980337 http://dx.doi.org/10.3390/diagnostics13061029 |
_version_ | 1785014031216541696 |
---|---|
author | Corica, Ferdinando De Feo, Maria Silvia Gorica, Joana Sidrak, Marko Magdi Abdou Conte, Miriam Filippi, Luca Schillaci, Orazio De Vincentis, Giuseppe Frantellizzi, Viviana |
author_facet | Corica, Ferdinando De Feo, Maria Silvia Gorica, Joana Sidrak, Marko Magdi Abdou Conte, Miriam Filippi, Luca Schillaci, Orazio De Vincentis, Giuseppe Frantellizzi, Viviana |
author_sort | Corica, Ferdinando |
collection | PubMed |
description | Parkinson’s disease is the second most common neurodegenerative disorder, affecting 2–3% of the population of patients >65 years. Although the standard diagnosis of PD is clinical, neuroimaging plays a key role in the evaluation of patients who present symptoms related to neurodegenerative disorders. MRI, DAT-SPECT, and PET with [(18)F]-FDG are routinely used in the diagnosis and focus on the investigation of morphological changes, nigrostriatal degeneration or shifts in glucose metabolism in patients with parkinsonian syndromes. The aim of this study is to review the current PET radiotracers targeting TSPO, a transmembrane protein that is overexpressed by microglia in another pathophysiological process associated with neurodegenerative disorders known as neuroinflammation. To the best of our knowledge, neuroinflammation is present not only in PD but in many other neurodegenerative disorders, including AD, DLB, and MSA, as well as atypical parkinsonian syndromes. Therefore, in this study, specific patterns of microglial activation in PD and the differences in distribution volumes of these radiotracers in patients with PD as compared to other neurodegenerative disorders are reviewed. |
format | Online Article Text |
id | pubmed-10047854 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100478542023-03-29 PET Imaging of Neuro-Inflammation with Tracers Targeting the Translocator Protein (TSPO), a Systematic Review: From Bench to Bedside Corica, Ferdinando De Feo, Maria Silvia Gorica, Joana Sidrak, Marko Magdi Abdou Conte, Miriam Filippi, Luca Schillaci, Orazio De Vincentis, Giuseppe Frantellizzi, Viviana Diagnostics (Basel) Systematic Review Parkinson’s disease is the second most common neurodegenerative disorder, affecting 2–3% of the population of patients >65 years. Although the standard diagnosis of PD is clinical, neuroimaging plays a key role in the evaluation of patients who present symptoms related to neurodegenerative disorders. MRI, DAT-SPECT, and PET with [(18)F]-FDG are routinely used in the diagnosis and focus on the investigation of morphological changes, nigrostriatal degeneration or shifts in glucose metabolism in patients with parkinsonian syndromes. The aim of this study is to review the current PET radiotracers targeting TSPO, a transmembrane protein that is overexpressed by microglia in another pathophysiological process associated with neurodegenerative disorders known as neuroinflammation. To the best of our knowledge, neuroinflammation is present not only in PD but in many other neurodegenerative disorders, including AD, DLB, and MSA, as well as atypical parkinsonian syndromes. Therefore, in this study, specific patterns of microglial activation in PD and the differences in distribution volumes of these radiotracers in patients with PD as compared to other neurodegenerative disorders are reviewed. MDPI 2023-03-08 /pmc/articles/PMC10047854/ /pubmed/36980337 http://dx.doi.org/10.3390/diagnostics13061029 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Systematic Review Corica, Ferdinando De Feo, Maria Silvia Gorica, Joana Sidrak, Marko Magdi Abdou Conte, Miriam Filippi, Luca Schillaci, Orazio De Vincentis, Giuseppe Frantellizzi, Viviana PET Imaging of Neuro-Inflammation with Tracers Targeting the Translocator Protein (TSPO), a Systematic Review: From Bench to Bedside |
title | PET Imaging of Neuro-Inflammation with Tracers Targeting the Translocator Protein (TSPO), a Systematic Review: From Bench to Bedside |
title_full | PET Imaging of Neuro-Inflammation with Tracers Targeting the Translocator Protein (TSPO), a Systematic Review: From Bench to Bedside |
title_fullStr | PET Imaging of Neuro-Inflammation with Tracers Targeting the Translocator Protein (TSPO), a Systematic Review: From Bench to Bedside |
title_full_unstemmed | PET Imaging of Neuro-Inflammation with Tracers Targeting the Translocator Protein (TSPO), a Systematic Review: From Bench to Bedside |
title_short | PET Imaging of Neuro-Inflammation with Tracers Targeting the Translocator Protein (TSPO), a Systematic Review: From Bench to Bedside |
title_sort | pet imaging of neuro-inflammation with tracers targeting the translocator protein (tspo), a systematic review: from bench to bedside |
topic | Systematic Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10047854/ https://www.ncbi.nlm.nih.gov/pubmed/36980337 http://dx.doi.org/10.3390/diagnostics13061029 |
work_keys_str_mv | AT coricaferdinando petimagingofneuroinflammationwithtracerstargetingthetranslocatorproteintspoasystematicreviewfrombenchtobedside AT defeomariasilvia petimagingofneuroinflammationwithtracerstargetingthetranslocatorproteintspoasystematicreviewfrombenchtobedside AT goricajoana petimagingofneuroinflammationwithtracerstargetingthetranslocatorproteintspoasystematicreviewfrombenchtobedside AT sidrakmarkomagdiabdou petimagingofneuroinflammationwithtracerstargetingthetranslocatorproteintspoasystematicreviewfrombenchtobedside AT contemiriam petimagingofneuroinflammationwithtracerstargetingthetranslocatorproteintspoasystematicreviewfrombenchtobedside AT filippiluca petimagingofneuroinflammationwithtracerstargetingthetranslocatorproteintspoasystematicreviewfrombenchtobedside AT schillaciorazio petimagingofneuroinflammationwithtracerstargetingthetranslocatorproteintspoasystematicreviewfrombenchtobedside AT devincentisgiuseppe petimagingofneuroinflammationwithtracerstargetingthetranslocatorproteintspoasystematicreviewfrombenchtobedside AT frantellizziviviana petimagingofneuroinflammationwithtracerstargetingthetranslocatorproteintspoasystematicreviewfrombenchtobedside |