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Direct Comparison of Two Different Definitions with Biochemical Recurrence after Low-Dose-Rate Brachytherapy for Prostate Cancer

We aimed to determine whether biochemical recurrence-free survival (BRFS) of patients with prostate cancer (PCa) who received low-dose-rate brachytherapy (LDR-BT) differed according to the definition of biochemical recurrence (BCR) after radical prostatectomy (RP) and the definition given by the Jap...

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Autores principales: Takeuchi, Shinichi, Iinuma, Koji, Nakane, Keita, Nakano, Masahiro, Kawase, Makoto, Kawase, Kota, Takai, Manabu, Kato, Daiki, Mori, Takayuki, Takano, Hirota, Kumano, Tomoyasu, Matsuo, Masayuki, Koie, Takuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10047870/
https://www.ncbi.nlm.nih.gov/pubmed/36975425
http://dx.doi.org/10.3390/curroncol30030212
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author Takeuchi, Shinichi
Iinuma, Koji
Nakane, Keita
Nakano, Masahiro
Kawase, Makoto
Kawase, Kota
Takai, Manabu
Kato, Daiki
Mori, Takayuki
Takano, Hirota
Kumano, Tomoyasu
Matsuo, Masayuki
Koie, Takuya
author_facet Takeuchi, Shinichi
Iinuma, Koji
Nakane, Keita
Nakano, Masahiro
Kawase, Makoto
Kawase, Kota
Takai, Manabu
Kato, Daiki
Mori, Takayuki
Takano, Hirota
Kumano, Tomoyasu
Matsuo, Masayuki
Koie, Takuya
author_sort Takeuchi, Shinichi
collection PubMed
description We aimed to determine whether biochemical recurrence-free survival (BRFS) of patients with prostate cancer (PCa) who received low-dose-rate brachytherapy (LDR-BT) differed according to the definition of biochemical recurrence (BCR) after radical prostatectomy (RP) and the definition given by the Japanese Prostate Cancer Outcome Study of Permanent Iodine-125 Seed Implantation (J-POPS). We reviewed the clinical records of 476 consecutive patients with PCa who received LDR-BT at the Gifu University Hospital. The primary endpoint of this study was the difference in BRFS between the two aforementioned definitions. When the follow-up period ended, 74 (15.5%) and 20 (4.2%) patients had BCR according to the RP and J-POPS definitions, respectively. The 5-year BRFS rates were 85.0% and 96.9% for the RP and J-POPS definitions, respectively (p < 0.005). According to the RP definition, the 5-year BRFS rates were 80.6% in the group aged <63 years and 86.6% in those aged ≥63 years (p = 0.050). According to the J-POPS definition, the 5-year BRFS rates were 94.1% and 97.8% in the groups aged <63 years and ≥63 years, respectively (p = 0.005). The definition of recurrence in LDR-BT may need to be reconsidered.
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spelling pubmed-100478702023-03-29 Direct Comparison of Two Different Definitions with Biochemical Recurrence after Low-Dose-Rate Brachytherapy for Prostate Cancer Takeuchi, Shinichi Iinuma, Koji Nakane, Keita Nakano, Masahiro Kawase, Makoto Kawase, Kota Takai, Manabu Kato, Daiki Mori, Takayuki Takano, Hirota Kumano, Tomoyasu Matsuo, Masayuki Koie, Takuya Curr Oncol Article We aimed to determine whether biochemical recurrence-free survival (BRFS) of patients with prostate cancer (PCa) who received low-dose-rate brachytherapy (LDR-BT) differed according to the definition of biochemical recurrence (BCR) after radical prostatectomy (RP) and the definition given by the Japanese Prostate Cancer Outcome Study of Permanent Iodine-125 Seed Implantation (J-POPS). We reviewed the clinical records of 476 consecutive patients with PCa who received LDR-BT at the Gifu University Hospital. The primary endpoint of this study was the difference in BRFS between the two aforementioned definitions. When the follow-up period ended, 74 (15.5%) and 20 (4.2%) patients had BCR according to the RP and J-POPS definitions, respectively. The 5-year BRFS rates were 85.0% and 96.9% for the RP and J-POPS definitions, respectively (p < 0.005). According to the RP definition, the 5-year BRFS rates were 80.6% in the group aged <63 years and 86.6% in those aged ≥63 years (p = 0.050). According to the J-POPS definition, the 5-year BRFS rates were 94.1% and 97.8% in the groups aged <63 years and ≥63 years, respectively (p = 0.005). The definition of recurrence in LDR-BT may need to be reconsidered. MDPI 2023-02-26 /pmc/articles/PMC10047870/ /pubmed/36975425 http://dx.doi.org/10.3390/curroncol30030212 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Takeuchi, Shinichi
Iinuma, Koji
Nakane, Keita
Nakano, Masahiro
Kawase, Makoto
Kawase, Kota
Takai, Manabu
Kato, Daiki
Mori, Takayuki
Takano, Hirota
Kumano, Tomoyasu
Matsuo, Masayuki
Koie, Takuya
Direct Comparison of Two Different Definitions with Biochemical Recurrence after Low-Dose-Rate Brachytherapy for Prostate Cancer
title Direct Comparison of Two Different Definitions with Biochemical Recurrence after Low-Dose-Rate Brachytherapy for Prostate Cancer
title_full Direct Comparison of Two Different Definitions with Biochemical Recurrence after Low-Dose-Rate Brachytherapy for Prostate Cancer
title_fullStr Direct Comparison of Two Different Definitions with Biochemical Recurrence after Low-Dose-Rate Brachytherapy for Prostate Cancer
title_full_unstemmed Direct Comparison of Two Different Definitions with Biochemical Recurrence after Low-Dose-Rate Brachytherapy for Prostate Cancer
title_short Direct Comparison of Two Different Definitions with Biochemical Recurrence after Low-Dose-Rate Brachytherapy for Prostate Cancer
title_sort direct comparison of two different definitions with biochemical recurrence after low-dose-rate brachytherapy for prostate cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10047870/
https://www.ncbi.nlm.nih.gov/pubmed/36975425
http://dx.doi.org/10.3390/curroncol30030212
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