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Genomics of Dwarfism in Italian Local Chicken Breeds
The identification of the dwarf phenotype in chicken is based on body weight, height, and shank length, leaving the differentiation between dwarf and small breeds ambiguous. The aims of the present study were to characterize the sequence variations associated with the dwarf phenotype in three Italia...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10047989/ https://www.ncbi.nlm.nih.gov/pubmed/36980905 http://dx.doi.org/10.3390/genes14030633 |
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author | Perini, Francesco Cendron, Filippo Wu, Zhou Sevane, Natalia Li, Zhiqiang Huang, Chunhua Smith, Jacqueline Lasagna, Emiliano Cassandro, Martino Penasa, Mauro |
author_facet | Perini, Francesco Cendron, Filippo Wu, Zhou Sevane, Natalia Li, Zhiqiang Huang, Chunhua Smith, Jacqueline Lasagna, Emiliano Cassandro, Martino Penasa, Mauro |
author_sort | Perini, Francesco |
collection | PubMed |
description | The identification of the dwarf phenotype in chicken is based on body weight, height, and shank length, leaving the differentiation between dwarf and small breeds ambiguous. The aims of the present study were to characterize the sequence variations associated with the dwarf phenotype in three Italian chicken breeds and to investigate the genes associated with their phenotype. Five hundred and forty-one chickens from 23 local breeds (from 20 to 24 animals per breed) were sampled. All animals were genotyped with the 600 K chicken SNP array. Three breeds were described as “dwarf”, namely, Mericanel della Brianza (MERI), Mugellese (MUG), and Pepoi (PPP). We compared MERI, MUG, and PPP with the four heaviest breeds in the dataset by performing genome-wide association studies. Results showed significant SNPs associated with dwarfism in the MERI and MUG breeds, which shared a candidate genomic region on chromosome 1. Due to this similarity, MERI and MUG were analyzed together as a meta-population, observing significant SNPs in the LEMD3 and HMGA2 genes, which were previously reported as being responsible for dwarfism in different species. In conclusion, MERI and MUG breeds seem to share a genetic basis of dwarfism, which differentiates them from the small PPP breed. |
format | Online Article Text |
id | pubmed-10047989 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100479892023-03-29 Genomics of Dwarfism in Italian Local Chicken Breeds Perini, Francesco Cendron, Filippo Wu, Zhou Sevane, Natalia Li, Zhiqiang Huang, Chunhua Smith, Jacqueline Lasagna, Emiliano Cassandro, Martino Penasa, Mauro Genes (Basel) Article The identification of the dwarf phenotype in chicken is based on body weight, height, and shank length, leaving the differentiation between dwarf and small breeds ambiguous. The aims of the present study were to characterize the sequence variations associated with the dwarf phenotype in three Italian chicken breeds and to investigate the genes associated with their phenotype. Five hundred and forty-one chickens from 23 local breeds (from 20 to 24 animals per breed) were sampled. All animals were genotyped with the 600 K chicken SNP array. Three breeds were described as “dwarf”, namely, Mericanel della Brianza (MERI), Mugellese (MUG), and Pepoi (PPP). We compared MERI, MUG, and PPP with the four heaviest breeds in the dataset by performing genome-wide association studies. Results showed significant SNPs associated with dwarfism in the MERI and MUG breeds, which shared a candidate genomic region on chromosome 1. Due to this similarity, MERI and MUG were analyzed together as a meta-population, observing significant SNPs in the LEMD3 and HMGA2 genes, which were previously reported as being responsible for dwarfism in different species. In conclusion, MERI and MUG breeds seem to share a genetic basis of dwarfism, which differentiates them from the small PPP breed. MDPI 2023-03-03 /pmc/articles/PMC10047989/ /pubmed/36980905 http://dx.doi.org/10.3390/genes14030633 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Perini, Francesco Cendron, Filippo Wu, Zhou Sevane, Natalia Li, Zhiqiang Huang, Chunhua Smith, Jacqueline Lasagna, Emiliano Cassandro, Martino Penasa, Mauro Genomics of Dwarfism in Italian Local Chicken Breeds |
title | Genomics of Dwarfism in Italian Local Chicken Breeds |
title_full | Genomics of Dwarfism in Italian Local Chicken Breeds |
title_fullStr | Genomics of Dwarfism in Italian Local Chicken Breeds |
title_full_unstemmed | Genomics of Dwarfism in Italian Local Chicken Breeds |
title_short | Genomics of Dwarfism in Italian Local Chicken Breeds |
title_sort | genomics of dwarfism in italian local chicken breeds |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10047989/ https://www.ncbi.nlm.nih.gov/pubmed/36980905 http://dx.doi.org/10.3390/genes14030633 |
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