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Genomics of Dwarfism in Italian Local Chicken Breeds

The identification of the dwarf phenotype in chicken is based on body weight, height, and shank length, leaving the differentiation between dwarf and small breeds ambiguous. The aims of the present study were to characterize the sequence variations associated with the dwarf phenotype in three Italia...

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Autores principales: Perini, Francesco, Cendron, Filippo, Wu, Zhou, Sevane, Natalia, Li, Zhiqiang, Huang, Chunhua, Smith, Jacqueline, Lasagna, Emiliano, Cassandro, Martino, Penasa, Mauro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10047989/
https://www.ncbi.nlm.nih.gov/pubmed/36980905
http://dx.doi.org/10.3390/genes14030633
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author Perini, Francesco
Cendron, Filippo
Wu, Zhou
Sevane, Natalia
Li, Zhiqiang
Huang, Chunhua
Smith, Jacqueline
Lasagna, Emiliano
Cassandro, Martino
Penasa, Mauro
author_facet Perini, Francesco
Cendron, Filippo
Wu, Zhou
Sevane, Natalia
Li, Zhiqiang
Huang, Chunhua
Smith, Jacqueline
Lasagna, Emiliano
Cassandro, Martino
Penasa, Mauro
author_sort Perini, Francesco
collection PubMed
description The identification of the dwarf phenotype in chicken is based on body weight, height, and shank length, leaving the differentiation between dwarf and small breeds ambiguous. The aims of the present study were to characterize the sequence variations associated with the dwarf phenotype in three Italian chicken breeds and to investigate the genes associated with their phenotype. Five hundred and forty-one chickens from 23 local breeds (from 20 to 24 animals per breed) were sampled. All animals were genotyped with the 600 K chicken SNP array. Three breeds were described as “dwarf”, namely, Mericanel della Brianza (MERI), Mugellese (MUG), and Pepoi (PPP). We compared MERI, MUG, and PPP with the four heaviest breeds in the dataset by performing genome-wide association studies. Results showed significant SNPs associated with dwarfism in the MERI and MUG breeds, which shared a candidate genomic region on chromosome 1. Due to this similarity, MERI and MUG were analyzed together as a meta-population, observing significant SNPs in the LEMD3 and HMGA2 genes, which were previously reported as being responsible for dwarfism in different species. In conclusion, MERI and MUG breeds seem to share a genetic basis of dwarfism, which differentiates them from the small PPP breed.
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spelling pubmed-100479892023-03-29 Genomics of Dwarfism in Italian Local Chicken Breeds Perini, Francesco Cendron, Filippo Wu, Zhou Sevane, Natalia Li, Zhiqiang Huang, Chunhua Smith, Jacqueline Lasagna, Emiliano Cassandro, Martino Penasa, Mauro Genes (Basel) Article The identification of the dwarf phenotype in chicken is based on body weight, height, and shank length, leaving the differentiation between dwarf and small breeds ambiguous. The aims of the present study were to characterize the sequence variations associated with the dwarf phenotype in three Italian chicken breeds and to investigate the genes associated with their phenotype. Five hundred and forty-one chickens from 23 local breeds (from 20 to 24 animals per breed) were sampled. All animals were genotyped with the 600 K chicken SNP array. Three breeds were described as “dwarf”, namely, Mericanel della Brianza (MERI), Mugellese (MUG), and Pepoi (PPP). We compared MERI, MUG, and PPP with the four heaviest breeds in the dataset by performing genome-wide association studies. Results showed significant SNPs associated with dwarfism in the MERI and MUG breeds, which shared a candidate genomic region on chromosome 1. Due to this similarity, MERI and MUG were analyzed together as a meta-population, observing significant SNPs in the LEMD3 and HMGA2 genes, which were previously reported as being responsible for dwarfism in different species. In conclusion, MERI and MUG breeds seem to share a genetic basis of dwarfism, which differentiates them from the small PPP breed. MDPI 2023-03-03 /pmc/articles/PMC10047989/ /pubmed/36980905 http://dx.doi.org/10.3390/genes14030633 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Perini, Francesco
Cendron, Filippo
Wu, Zhou
Sevane, Natalia
Li, Zhiqiang
Huang, Chunhua
Smith, Jacqueline
Lasagna, Emiliano
Cassandro, Martino
Penasa, Mauro
Genomics of Dwarfism in Italian Local Chicken Breeds
title Genomics of Dwarfism in Italian Local Chicken Breeds
title_full Genomics of Dwarfism in Italian Local Chicken Breeds
title_fullStr Genomics of Dwarfism in Italian Local Chicken Breeds
title_full_unstemmed Genomics of Dwarfism in Italian Local Chicken Breeds
title_short Genomics of Dwarfism in Italian Local Chicken Breeds
title_sort genomics of dwarfism in italian local chicken breeds
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10047989/
https://www.ncbi.nlm.nih.gov/pubmed/36980905
http://dx.doi.org/10.3390/genes14030633
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