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Single-Nucleotide Polymorphisms as Biomarkers of Antipsychotic-Induced Akathisia: Systematic Review
Antipsychotic-induced akathisia (AIA) is a movement disorder characterized by a subjective feeling of inner restlessness or nervousness with an irresistible urge to move, resulting in repetitive movements of the limbs and torso, while taking antipsychotics (APs). In recent years, there have been som...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10048266/ https://www.ncbi.nlm.nih.gov/pubmed/36980888 http://dx.doi.org/10.3390/genes14030616 |
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author | Nasyrova, Regina F. Vaiman, Elena E. Repkina, Vera V. Khasanova, Aiperi K. Asadullin, Azat R. Shipulin, German A. Altynbekov, Kuanysh S. Al-Zamil, Mustafa Petrova, Marina M. Shnayder, Natalia A. |
author_facet | Nasyrova, Regina F. Vaiman, Elena E. Repkina, Vera V. Khasanova, Aiperi K. Asadullin, Azat R. Shipulin, German A. Altynbekov, Kuanysh S. Al-Zamil, Mustafa Petrova, Marina M. Shnayder, Natalia A. |
author_sort | Nasyrova, Regina F. |
collection | PubMed |
description | Antipsychotic-induced akathisia (AIA) is a movement disorder characterized by a subjective feeling of inner restlessness or nervousness with an irresistible urge to move, resulting in repetitive movements of the limbs and torso, while taking antipsychotics (APs). In recent years, there have been some associative genetic studies of the predisposition to the development of AIA. Objective: The goal of our study was to review the results of associative genetic and genome-wide studies and to systematize and update the knowledge on the genetic predictors of AIA in patients with schizophrenia (Sch). Methods: We searched full-text publications in PubMed, Web of Science, Springer, Google Scholar, and e-Library databases from 1977 to 2022. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) quality scale was used for the critical selection of the studies. Results: We identified 37 articles, of which 3 were included in the review. Thus, the C allele of rs1800498 (59414 C>T) and the A allele of rs1800497 (17316 G>A) (TaqIA) from the DRD2 gene as well as the TT genotype rs13212041 (77461407 C>T) from the HTR1B gene were found to be associated with AIA. Conclusions: Uncovering the genetic biomarkers of AIA may provide a key to developing a strategy for the personalized prevention and treatment of this adverse neurological drug reaction of APs in patients with Sch in real clinical practice. |
format | Online Article Text |
id | pubmed-10048266 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100482662023-03-29 Single-Nucleotide Polymorphisms as Biomarkers of Antipsychotic-Induced Akathisia: Systematic Review Nasyrova, Regina F. Vaiman, Elena E. Repkina, Vera V. Khasanova, Aiperi K. Asadullin, Azat R. Shipulin, German A. Altynbekov, Kuanysh S. Al-Zamil, Mustafa Petrova, Marina M. Shnayder, Natalia A. Genes (Basel) Review Antipsychotic-induced akathisia (AIA) is a movement disorder characterized by a subjective feeling of inner restlessness or nervousness with an irresistible urge to move, resulting in repetitive movements of the limbs and torso, while taking antipsychotics (APs). In recent years, there have been some associative genetic studies of the predisposition to the development of AIA. Objective: The goal of our study was to review the results of associative genetic and genome-wide studies and to systematize and update the knowledge on the genetic predictors of AIA in patients with schizophrenia (Sch). Methods: We searched full-text publications in PubMed, Web of Science, Springer, Google Scholar, and e-Library databases from 1977 to 2022. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) quality scale was used for the critical selection of the studies. Results: We identified 37 articles, of which 3 were included in the review. Thus, the C allele of rs1800498 (59414 C>T) and the A allele of rs1800497 (17316 G>A) (TaqIA) from the DRD2 gene as well as the TT genotype rs13212041 (77461407 C>T) from the HTR1B gene were found to be associated with AIA. Conclusions: Uncovering the genetic biomarkers of AIA may provide a key to developing a strategy for the personalized prevention and treatment of this adverse neurological drug reaction of APs in patients with Sch in real clinical practice. MDPI 2023-02-28 /pmc/articles/PMC10048266/ /pubmed/36980888 http://dx.doi.org/10.3390/genes14030616 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Nasyrova, Regina F. Vaiman, Elena E. Repkina, Vera V. Khasanova, Aiperi K. Asadullin, Azat R. Shipulin, German A. Altynbekov, Kuanysh S. Al-Zamil, Mustafa Petrova, Marina M. Shnayder, Natalia A. Single-Nucleotide Polymorphisms as Biomarkers of Antipsychotic-Induced Akathisia: Systematic Review |
title | Single-Nucleotide Polymorphisms as Biomarkers of Antipsychotic-Induced Akathisia: Systematic Review |
title_full | Single-Nucleotide Polymorphisms as Biomarkers of Antipsychotic-Induced Akathisia: Systematic Review |
title_fullStr | Single-Nucleotide Polymorphisms as Biomarkers of Antipsychotic-Induced Akathisia: Systematic Review |
title_full_unstemmed | Single-Nucleotide Polymorphisms as Biomarkers of Antipsychotic-Induced Akathisia: Systematic Review |
title_short | Single-Nucleotide Polymorphisms as Biomarkers of Antipsychotic-Induced Akathisia: Systematic Review |
title_sort | single-nucleotide polymorphisms as biomarkers of antipsychotic-induced akathisia: systematic review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10048266/ https://www.ncbi.nlm.nih.gov/pubmed/36980888 http://dx.doi.org/10.3390/genes14030616 |
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