Therapeutic Targeting of P53: A Comparative Analysis of APR-246 and COTI-2 in Human Tumor Primary Culture 3-D Explants

Background: TP53 is the most commonly mutated gene in human cancer with loss of function mutations largely concentrated in “hotspots” affecting DNA binding. APR-246 and COTI-2 are small molecules under investigation in P53 mutated cancers. APR binds to P53 cysteine residues, altering conformation, w...

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Detalles Bibliográficos
Autores principales: Nagourney, Adam J., Gipoor, Joshua B., Evans, Steven S., D’Amora, Paulo, Duesberg, Max S., Bernard, Paula J., Francisco, Federico, Nagourney, Robert A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10048363/
https://www.ncbi.nlm.nih.gov/pubmed/36981018
http://dx.doi.org/10.3390/genes14030747

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10048363/
https://www.ncbi.nlm.nih.gov/pubmed/36981018
http://dx.doi.org/10.3390/genes14030747

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