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Cause of Death among Long-Term Cancer Survivors: The NANDE Study

Survival information for Japanese patients with cancer is based only on survival status and the cause of death among these patients remains unclear. In this study, Osaka Cancer Registry data (1985–2014) and vital statistics data (1985–2016) were linked to create a database, permitting the extraction...

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Autores principales: Fujii, Makoto, Morishima, Toshitaka, Nagayasu, Mayumi, Kudo, Haruka, Ohno, Yuko, Sobue, Tomotaka, Miyashiro, Isao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10048527/
https://www.ncbi.nlm.nih.gov/pubmed/36981492
http://dx.doi.org/10.3390/healthcare11060835
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author Fujii, Makoto
Morishima, Toshitaka
Nagayasu, Mayumi
Kudo, Haruka
Ohno, Yuko
Sobue, Tomotaka
Miyashiro, Isao
author_facet Fujii, Makoto
Morishima, Toshitaka
Nagayasu, Mayumi
Kudo, Haruka
Ohno, Yuko
Sobue, Tomotaka
Miyashiro, Isao
author_sort Fujii, Makoto
collection PubMed
description Survival information for Japanese patients with cancer is based only on survival status and the cause of death among these patients remains unclear. In this study, Osaka Cancer Registry data (1985–2014) and vital statistics data (1985–2016) were linked to create a database, permitting the extraction of data on the causes of death. In total, 522,566 subjects diagnosed with cancer between 1995 and 2011 were analyzed. Follow-up for vital status was conducted 5 and 10 years after cancer diagnosis. To evaluate the three causes of death (index cancer, non-index cancer, and non-cancer death), cause-specific hazard and cumulative incidence functions were estimated using a life table and Gray’s methods. The number of deaths owing to any of the causes in the observation period (median: 3.51 years, mean: 4.90 years) was 394,146. The 5- and 10-year cancer-specific survival rate was 48.56% and 39.92%, respectively. Immediately after cancer onset, the hazard of index cancer death was high. The proportion of non-index cancer deaths was high in patients with mouth and pharynx cancers. The hazard of index cancer death remained constant for breast and liver cancers. In prostate, breast, and laryngeal cancers with good prognosis, the hazard of non-index cancer and non-cancer death constantly increased.
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spelling pubmed-100485272023-03-29 Cause of Death among Long-Term Cancer Survivors: The NANDE Study Fujii, Makoto Morishima, Toshitaka Nagayasu, Mayumi Kudo, Haruka Ohno, Yuko Sobue, Tomotaka Miyashiro, Isao Healthcare (Basel) Article Survival information for Japanese patients with cancer is based only on survival status and the cause of death among these patients remains unclear. In this study, Osaka Cancer Registry data (1985–2014) and vital statistics data (1985–2016) were linked to create a database, permitting the extraction of data on the causes of death. In total, 522,566 subjects diagnosed with cancer between 1995 and 2011 were analyzed. Follow-up for vital status was conducted 5 and 10 years after cancer diagnosis. To evaluate the three causes of death (index cancer, non-index cancer, and non-cancer death), cause-specific hazard and cumulative incidence functions were estimated using a life table and Gray’s methods. The number of deaths owing to any of the causes in the observation period (median: 3.51 years, mean: 4.90 years) was 394,146. The 5- and 10-year cancer-specific survival rate was 48.56% and 39.92%, respectively. Immediately after cancer onset, the hazard of index cancer death was high. The proportion of non-index cancer deaths was high in patients with mouth and pharynx cancers. The hazard of index cancer death remained constant for breast and liver cancers. In prostate, breast, and laryngeal cancers with good prognosis, the hazard of non-index cancer and non-cancer death constantly increased. MDPI 2023-03-13 /pmc/articles/PMC10048527/ /pubmed/36981492 http://dx.doi.org/10.3390/healthcare11060835 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Fujii, Makoto
Morishima, Toshitaka
Nagayasu, Mayumi
Kudo, Haruka
Ohno, Yuko
Sobue, Tomotaka
Miyashiro, Isao
Cause of Death among Long-Term Cancer Survivors: The NANDE Study
title Cause of Death among Long-Term Cancer Survivors: The NANDE Study
title_full Cause of Death among Long-Term Cancer Survivors: The NANDE Study
title_fullStr Cause of Death among Long-Term Cancer Survivors: The NANDE Study
title_full_unstemmed Cause of Death among Long-Term Cancer Survivors: The NANDE Study
title_short Cause of Death among Long-Term Cancer Survivors: The NANDE Study
title_sort cause of death among long-term cancer survivors: the nande study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10048527/
https://www.ncbi.nlm.nih.gov/pubmed/36981492
http://dx.doi.org/10.3390/healthcare11060835
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