Biomanufacturing Recombinantly Expressed Cripto-1 Protein in Anchorage-Dependent Mammalian Cells Growing in Suspension Bioreactors within a Three-Dimensional Hydrogel Microcarrier

Biotherapeutic soluble proteins that are recombinantly expressed in mammalian cells can pose a challenge when biomanufacturing in three-dimensional (3D) suspension culture systems. Herein, we tested a 3D hydrogel microcarrier for a suspension culture of HEK293 cells overexpressing recombinant Cripto...

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Detalles Bibliográficos
Autores principales: Lev, Rachel, Bar-Am, Orit, Lati, Yoni, Guardiola, Ombretta, Minchiotti, Gabriella, Seliktar, Dror
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10048735/
https://www.ncbi.nlm.nih.gov/pubmed/36975692
http://dx.doi.org/10.3390/gels9030243

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