Cargando…

Fate Decisions of Chicken Primordial Germ Cells (PGCs): Development, Integrity, Sex Determination, and Self-Renewal Mechanisms

Primordial germ cells (PGCs) are precursor cells of sperm and eggs. The fate decisions of chicken PGCs in terms of their development, integrity, and sex determination have unique features, thereby providing insights into evolutionary developmental biology. Additionally, fate decisions in the context...

Descripción completa

Detalles Bibliográficos
Autores principales: Ichikawa, Kennosuke, Horiuchi, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10048776/
https://www.ncbi.nlm.nih.gov/pubmed/36980885
http://dx.doi.org/10.3390/genes14030612
_version_ 1785014280214544384
author Ichikawa, Kennosuke
Horiuchi, Hiroyuki
author_facet Ichikawa, Kennosuke
Horiuchi, Hiroyuki
author_sort Ichikawa, Kennosuke
collection PubMed
description Primordial germ cells (PGCs) are precursor cells of sperm and eggs. The fate decisions of chicken PGCs in terms of their development, integrity, and sex determination have unique features, thereby providing insights into evolutionary developmental biology. Additionally, fate decisions in the context of a self-renewal mechanism have been applied to establish culture protocols for chicken PGCs, enabling the production of genome-edited chickens and the conservation of genetic resources. Thus, studies on the fate decisions of chicken PGCs have significantly contributed to both academic and industrial development. Furthermore, studies on fate decisions have rapidly advanced owing to the recent development of essential research technologies, such as genome editing and RNA sequencing. Here, we reviewed the status of fate decisions of chicken PGCs and provided insight into other important research issues that require attention.
format Online
Article
Text
id pubmed-10048776
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-100487762023-03-29 Fate Decisions of Chicken Primordial Germ Cells (PGCs): Development, Integrity, Sex Determination, and Self-Renewal Mechanisms Ichikawa, Kennosuke Horiuchi, Hiroyuki Genes (Basel) Review Primordial germ cells (PGCs) are precursor cells of sperm and eggs. The fate decisions of chicken PGCs in terms of their development, integrity, and sex determination have unique features, thereby providing insights into evolutionary developmental biology. Additionally, fate decisions in the context of a self-renewal mechanism have been applied to establish culture protocols for chicken PGCs, enabling the production of genome-edited chickens and the conservation of genetic resources. Thus, studies on the fate decisions of chicken PGCs have significantly contributed to both academic and industrial development. Furthermore, studies on fate decisions have rapidly advanced owing to the recent development of essential research technologies, such as genome editing and RNA sequencing. Here, we reviewed the status of fate decisions of chicken PGCs and provided insight into other important research issues that require attention. MDPI 2023-02-28 /pmc/articles/PMC10048776/ /pubmed/36980885 http://dx.doi.org/10.3390/genes14030612 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ichikawa, Kennosuke
Horiuchi, Hiroyuki
Fate Decisions of Chicken Primordial Germ Cells (PGCs): Development, Integrity, Sex Determination, and Self-Renewal Mechanisms
title Fate Decisions of Chicken Primordial Germ Cells (PGCs): Development, Integrity, Sex Determination, and Self-Renewal Mechanisms
title_full Fate Decisions of Chicken Primordial Germ Cells (PGCs): Development, Integrity, Sex Determination, and Self-Renewal Mechanisms
title_fullStr Fate Decisions of Chicken Primordial Germ Cells (PGCs): Development, Integrity, Sex Determination, and Self-Renewal Mechanisms
title_full_unstemmed Fate Decisions of Chicken Primordial Germ Cells (PGCs): Development, Integrity, Sex Determination, and Self-Renewal Mechanisms
title_short Fate Decisions of Chicken Primordial Germ Cells (PGCs): Development, Integrity, Sex Determination, and Self-Renewal Mechanisms
title_sort fate decisions of chicken primordial germ cells (pgcs): development, integrity, sex determination, and self-renewal mechanisms
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10048776/
https://www.ncbi.nlm.nih.gov/pubmed/36980885
http://dx.doi.org/10.3390/genes14030612
work_keys_str_mv AT ichikawakennosuke fatedecisionsofchickenprimordialgermcellspgcsdevelopmentintegritysexdeterminationandselfrenewalmechanisms
AT horiuchihiroyuki fatedecisionsofchickenprimordialgermcellspgcsdevelopmentintegritysexdeterminationandselfrenewalmechanisms