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Simple Complexity: Incorporating Bioinspired Delivery Machinery within Self-Assembled Peptide Biogels

Bioinspired self-assembly is a bottom-up strategy enabling biologically sophisticated nanostructured biogels that can mimic natural tissue. Self-assembling peptides (SAPs), carefully designed, form signal-rich supramolecular nanostructures that intertwine to form a hydrogel material that can be used...

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Autores principales: Li, Rui, Zhou, Qing-Ling, Tai, Min-Rui, Ashton-Mourney, Kathryn, Harty, Mathew I., Rifai, Aaqil, Parish, Clare L., Nisbet, David R., Zhong, Sai-Yi, Williams, Richard J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10048788/
https://www.ncbi.nlm.nih.gov/pubmed/36975648
http://dx.doi.org/10.3390/gels9030199
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author Li, Rui
Zhou, Qing-Ling
Tai, Min-Rui
Ashton-Mourney, Kathryn
Harty, Mathew I.
Rifai, Aaqil
Parish, Clare L.
Nisbet, David R.
Zhong, Sai-Yi
Williams, Richard J.
author_facet Li, Rui
Zhou, Qing-Ling
Tai, Min-Rui
Ashton-Mourney, Kathryn
Harty, Mathew I.
Rifai, Aaqil
Parish, Clare L.
Nisbet, David R.
Zhong, Sai-Yi
Williams, Richard J.
author_sort Li, Rui
collection PubMed
description Bioinspired self-assembly is a bottom-up strategy enabling biologically sophisticated nanostructured biogels that can mimic natural tissue. Self-assembling peptides (SAPs), carefully designed, form signal-rich supramolecular nanostructures that intertwine to form a hydrogel material that can be used for a range of cell and tissue engineering scaffolds. Using the tools of nature, they are a versatile framework for the supply and presentation of important biological factors. Recent developments have shown promise for many applications such as therapeutic gene, drug and cell delivery and yet are stable enough for large-scale tissue engineering. This is due to their excellent programmability—features can be incorporated for innate biocompatibility, biodegradability, synthetic feasibility, biological functionality and responsiveness to external stimuli. SAPs can be used independently or combined with other (macro)molecules to recapitulate surprisingly complex biological functions in a simple framework. It is easy to accomplish localized delivery, since they can be injected and can deliver targeted and sustained effects. In this review, we discuss the categories of SAPs, applications for gene and drug delivery, and their inherent design challenges. We highlight selected applications from the literature and make suggestions to advance the field with SAPs as a simple, yet smart delivery platform for emerging BioMedTech applications.
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spelling pubmed-100487882023-03-29 Simple Complexity: Incorporating Bioinspired Delivery Machinery within Self-Assembled Peptide Biogels Li, Rui Zhou, Qing-Ling Tai, Min-Rui Ashton-Mourney, Kathryn Harty, Mathew I. Rifai, Aaqil Parish, Clare L. Nisbet, David R. Zhong, Sai-Yi Williams, Richard J. Gels Review Bioinspired self-assembly is a bottom-up strategy enabling biologically sophisticated nanostructured biogels that can mimic natural tissue. Self-assembling peptides (SAPs), carefully designed, form signal-rich supramolecular nanostructures that intertwine to form a hydrogel material that can be used for a range of cell and tissue engineering scaffolds. Using the tools of nature, they are a versatile framework for the supply and presentation of important biological factors. Recent developments have shown promise for many applications such as therapeutic gene, drug and cell delivery and yet are stable enough for large-scale tissue engineering. This is due to their excellent programmability—features can be incorporated for innate biocompatibility, biodegradability, synthetic feasibility, biological functionality and responsiveness to external stimuli. SAPs can be used independently or combined with other (macro)molecules to recapitulate surprisingly complex biological functions in a simple framework. It is easy to accomplish localized delivery, since they can be injected and can deliver targeted and sustained effects. In this review, we discuss the categories of SAPs, applications for gene and drug delivery, and their inherent design challenges. We highlight selected applications from the literature and make suggestions to advance the field with SAPs as a simple, yet smart delivery platform for emerging BioMedTech applications. MDPI 2023-03-06 /pmc/articles/PMC10048788/ /pubmed/36975648 http://dx.doi.org/10.3390/gels9030199 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Li, Rui
Zhou, Qing-Ling
Tai, Min-Rui
Ashton-Mourney, Kathryn
Harty, Mathew I.
Rifai, Aaqil
Parish, Clare L.
Nisbet, David R.
Zhong, Sai-Yi
Williams, Richard J.
Simple Complexity: Incorporating Bioinspired Delivery Machinery within Self-Assembled Peptide Biogels
title Simple Complexity: Incorporating Bioinspired Delivery Machinery within Self-Assembled Peptide Biogels
title_full Simple Complexity: Incorporating Bioinspired Delivery Machinery within Self-Assembled Peptide Biogels
title_fullStr Simple Complexity: Incorporating Bioinspired Delivery Machinery within Self-Assembled Peptide Biogels
title_full_unstemmed Simple Complexity: Incorporating Bioinspired Delivery Machinery within Self-Assembled Peptide Biogels
title_short Simple Complexity: Incorporating Bioinspired Delivery Machinery within Self-Assembled Peptide Biogels
title_sort simple complexity: incorporating bioinspired delivery machinery within self-assembled peptide biogels
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10048788/
https://www.ncbi.nlm.nih.gov/pubmed/36975648
http://dx.doi.org/10.3390/gels9030199
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