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Research Progress on the Construction and Application of a Diabetic Zebrafish Model
Diabetes is a metabolic disease characterized by high blood glucose levels. With economic development and lifestyle changes, the prevalence of diabetes is increasing yearly. Thus, it has become an increasingly serious public health problem in countries around the world. The etiology of diabetes is c...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10048833/ https://www.ncbi.nlm.nih.gov/pubmed/36982274 http://dx.doi.org/10.3390/ijms24065195 |
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author | Cao, Yu Chen, Qianqian Liu, Yinai Jin, Libo Peng, Renyi |
author_facet | Cao, Yu Chen, Qianqian Liu, Yinai Jin, Libo Peng, Renyi |
author_sort | Cao, Yu |
collection | PubMed |
description | Diabetes is a metabolic disease characterized by high blood glucose levels. With economic development and lifestyle changes, the prevalence of diabetes is increasing yearly. Thus, it has become an increasingly serious public health problem in countries around the world. The etiology of diabetes is complex, and its pathogenic mechanisms are not completely clear. The use of diabetic animal models is helpful in the study of the pathogenesis of diabetes and the development of drugs. The emerging vertebrate model of zebrafish has many advantages, such as its small size, large number of eggs, short growth cycle, simple cultivation of adult fish, and effective improvement of experimental efficiency. Thus, this model is highly suitable for research as an animal model of diabetes. This review not only summarizes the advantages of zebrafish as a diabetes model, but also summarizes the construction methods and challenges of zebrafish models of type 1 diabetes, type 2 diabetes, and diabetes complications. This study provides valuable reference information for further study of the pathological mechanisms of diabetes and the research and development of new related therapeutic drugs. |
format | Online Article Text |
id | pubmed-10048833 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100488332023-03-29 Research Progress on the Construction and Application of a Diabetic Zebrafish Model Cao, Yu Chen, Qianqian Liu, Yinai Jin, Libo Peng, Renyi Int J Mol Sci Review Diabetes is a metabolic disease characterized by high blood glucose levels. With economic development and lifestyle changes, the prevalence of diabetes is increasing yearly. Thus, it has become an increasingly serious public health problem in countries around the world. The etiology of diabetes is complex, and its pathogenic mechanisms are not completely clear. The use of diabetic animal models is helpful in the study of the pathogenesis of diabetes and the development of drugs. The emerging vertebrate model of zebrafish has many advantages, such as its small size, large number of eggs, short growth cycle, simple cultivation of adult fish, and effective improvement of experimental efficiency. Thus, this model is highly suitable for research as an animal model of diabetes. This review not only summarizes the advantages of zebrafish as a diabetes model, but also summarizes the construction methods and challenges of zebrafish models of type 1 diabetes, type 2 diabetes, and diabetes complications. This study provides valuable reference information for further study of the pathological mechanisms of diabetes and the research and development of new related therapeutic drugs. MDPI 2023-03-08 /pmc/articles/PMC10048833/ /pubmed/36982274 http://dx.doi.org/10.3390/ijms24065195 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Cao, Yu Chen, Qianqian Liu, Yinai Jin, Libo Peng, Renyi Research Progress on the Construction and Application of a Diabetic Zebrafish Model |
title | Research Progress on the Construction and Application of a Diabetic Zebrafish Model |
title_full | Research Progress on the Construction and Application of a Diabetic Zebrafish Model |
title_fullStr | Research Progress on the Construction and Application of a Diabetic Zebrafish Model |
title_full_unstemmed | Research Progress on the Construction and Application of a Diabetic Zebrafish Model |
title_short | Research Progress on the Construction and Application of a Diabetic Zebrafish Model |
title_sort | research progress on the construction and application of a diabetic zebrafish model |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10048833/ https://www.ncbi.nlm.nih.gov/pubmed/36982274 http://dx.doi.org/10.3390/ijms24065195 |
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