Cargando…

Research Progress on the Construction and Application of a Diabetic Zebrafish Model

Diabetes is a metabolic disease characterized by high blood glucose levels. With economic development and lifestyle changes, the prevalence of diabetes is increasing yearly. Thus, it has become an increasingly serious public health problem in countries around the world. The etiology of diabetes is c...

Descripción completa

Detalles Bibliográficos
Autores principales: Cao, Yu, Chen, Qianqian, Liu, Yinai, Jin, Libo, Peng, Renyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10048833/
https://www.ncbi.nlm.nih.gov/pubmed/36982274
http://dx.doi.org/10.3390/ijms24065195
_version_ 1785014294987931648
author Cao, Yu
Chen, Qianqian
Liu, Yinai
Jin, Libo
Peng, Renyi
author_facet Cao, Yu
Chen, Qianqian
Liu, Yinai
Jin, Libo
Peng, Renyi
author_sort Cao, Yu
collection PubMed
description Diabetes is a metabolic disease characterized by high blood glucose levels. With economic development and lifestyle changes, the prevalence of diabetes is increasing yearly. Thus, it has become an increasingly serious public health problem in countries around the world. The etiology of diabetes is complex, and its pathogenic mechanisms are not completely clear. The use of diabetic animal models is helpful in the study of the pathogenesis of diabetes and the development of drugs. The emerging vertebrate model of zebrafish has many advantages, such as its small size, large number of eggs, short growth cycle, simple cultivation of adult fish, and effective improvement of experimental efficiency. Thus, this model is highly suitable for research as an animal model of diabetes. This review not only summarizes the advantages of zebrafish as a diabetes model, but also summarizes the construction methods and challenges of zebrafish models of type 1 diabetes, type 2 diabetes, and diabetes complications. This study provides valuable reference information for further study of the pathological mechanisms of diabetes and the research and development of new related therapeutic drugs.
format Online
Article
Text
id pubmed-10048833
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-100488332023-03-29 Research Progress on the Construction and Application of a Diabetic Zebrafish Model Cao, Yu Chen, Qianqian Liu, Yinai Jin, Libo Peng, Renyi Int J Mol Sci Review Diabetes is a metabolic disease characterized by high blood glucose levels. With economic development and lifestyle changes, the prevalence of diabetes is increasing yearly. Thus, it has become an increasingly serious public health problem in countries around the world. The etiology of diabetes is complex, and its pathogenic mechanisms are not completely clear. The use of diabetic animal models is helpful in the study of the pathogenesis of diabetes and the development of drugs. The emerging vertebrate model of zebrafish has many advantages, such as its small size, large number of eggs, short growth cycle, simple cultivation of adult fish, and effective improvement of experimental efficiency. Thus, this model is highly suitable for research as an animal model of diabetes. This review not only summarizes the advantages of zebrafish as a diabetes model, but also summarizes the construction methods and challenges of zebrafish models of type 1 diabetes, type 2 diabetes, and diabetes complications. This study provides valuable reference information for further study of the pathological mechanisms of diabetes and the research and development of new related therapeutic drugs. MDPI 2023-03-08 /pmc/articles/PMC10048833/ /pubmed/36982274 http://dx.doi.org/10.3390/ijms24065195 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Cao, Yu
Chen, Qianqian
Liu, Yinai
Jin, Libo
Peng, Renyi
Research Progress on the Construction and Application of a Diabetic Zebrafish Model
title Research Progress on the Construction and Application of a Diabetic Zebrafish Model
title_full Research Progress on the Construction and Application of a Diabetic Zebrafish Model
title_fullStr Research Progress on the Construction and Application of a Diabetic Zebrafish Model
title_full_unstemmed Research Progress on the Construction and Application of a Diabetic Zebrafish Model
title_short Research Progress on the Construction and Application of a Diabetic Zebrafish Model
title_sort research progress on the construction and application of a diabetic zebrafish model
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10048833/
https://www.ncbi.nlm.nih.gov/pubmed/36982274
http://dx.doi.org/10.3390/ijms24065195
work_keys_str_mv AT caoyu researchprogressontheconstructionandapplicationofadiabeticzebrafishmodel
AT chenqianqian researchprogressontheconstructionandapplicationofadiabeticzebrafishmodel
AT liuyinai researchprogressontheconstructionandapplicationofadiabeticzebrafishmodel
AT jinlibo researchprogressontheconstructionandapplicationofadiabeticzebrafishmodel
AT pengrenyi researchprogressontheconstructionandapplicationofadiabeticzebrafishmodel