Cargando…
Kinase Inhibitors in Genetic Diseases
Over the years, several studies have shown that kinase-regulated signaling pathways are involved in the development of rare genetic diseases. The study of the mechanisms underlying the onset of these diseases has opened a possible way for the development of targeted therapies using particular kinase...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10048847/ https://www.ncbi.nlm.nih.gov/pubmed/36982349 http://dx.doi.org/10.3390/ijms24065276 |
_version_ | 1785014298195525632 |
---|---|
author | D’Antona, Lucia Amato, Rosario Brescia, Carolina Rocca, Valentina Colao, Emma Iuliano, Rodolfo Blazer-Yost, Bonnie L. Perrotti, Nicola |
author_facet | D’Antona, Lucia Amato, Rosario Brescia, Carolina Rocca, Valentina Colao, Emma Iuliano, Rodolfo Blazer-Yost, Bonnie L. Perrotti, Nicola |
author_sort | D’Antona, Lucia |
collection | PubMed |
description | Over the years, several studies have shown that kinase-regulated signaling pathways are involved in the development of rare genetic diseases. The study of the mechanisms underlying the onset of these diseases has opened a possible way for the development of targeted therapies using particular kinase inhibitors. Some of these are currently used to treat other diseases, such as cancer. This review aims to describe the possibilities of using kinase inhibitors in genetic pathologies such as tuberous sclerosis, RASopathies, and ciliopathies, describing the various pathways involved and the possible targets already identified or currently under study. |
format | Online Article Text |
id | pubmed-10048847 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100488472023-03-29 Kinase Inhibitors in Genetic Diseases D’Antona, Lucia Amato, Rosario Brescia, Carolina Rocca, Valentina Colao, Emma Iuliano, Rodolfo Blazer-Yost, Bonnie L. Perrotti, Nicola Int J Mol Sci Review Over the years, several studies have shown that kinase-regulated signaling pathways are involved in the development of rare genetic diseases. The study of the mechanisms underlying the onset of these diseases has opened a possible way for the development of targeted therapies using particular kinase inhibitors. Some of these are currently used to treat other diseases, such as cancer. This review aims to describe the possibilities of using kinase inhibitors in genetic pathologies such as tuberous sclerosis, RASopathies, and ciliopathies, describing the various pathways involved and the possible targets already identified or currently under study. MDPI 2023-03-09 /pmc/articles/PMC10048847/ /pubmed/36982349 http://dx.doi.org/10.3390/ijms24065276 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review D’Antona, Lucia Amato, Rosario Brescia, Carolina Rocca, Valentina Colao, Emma Iuliano, Rodolfo Blazer-Yost, Bonnie L. Perrotti, Nicola Kinase Inhibitors in Genetic Diseases |
title | Kinase Inhibitors in Genetic Diseases |
title_full | Kinase Inhibitors in Genetic Diseases |
title_fullStr | Kinase Inhibitors in Genetic Diseases |
title_full_unstemmed | Kinase Inhibitors in Genetic Diseases |
title_short | Kinase Inhibitors in Genetic Diseases |
title_sort | kinase inhibitors in genetic diseases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10048847/ https://www.ncbi.nlm.nih.gov/pubmed/36982349 http://dx.doi.org/10.3390/ijms24065276 |
work_keys_str_mv | AT dantonalucia kinaseinhibitorsingeneticdiseases AT amatorosario kinaseinhibitorsingeneticdiseases AT bresciacarolina kinaseinhibitorsingeneticdiseases AT roccavalentina kinaseinhibitorsingeneticdiseases AT colaoemma kinaseinhibitorsingeneticdiseases AT iulianorodolfo kinaseinhibitorsingeneticdiseases AT blazeryostbonniel kinaseinhibitorsingeneticdiseases AT perrottinicola kinaseinhibitorsingeneticdiseases |