Cargando…

Kinase Inhibitors in Genetic Diseases

Over the years, several studies have shown that kinase-regulated signaling pathways are involved in the development of rare genetic diseases. The study of the mechanisms underlying the onset of these diseases has opened a possible way for the development of targeted therapies using particular kinase...

Descripción completa

Detalles Bibliográficos
Autores principales:	D’Antona, Lucia, Amato, Rosario, Brescia, Carolina, Rocca, Valentina, Colao, Emma, Iuliano, Rodolfo, Blazer-Yost, Bonnie L., Perrotti, Nicola
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10048847/ https://www.ncbi.nlm.nih.gov/pubmed/36982349 http://dx.doi.org/10.3390/ijms24065276

Ejemplares similares

RANBP1 (RAN Binding Protein 1): The Missing Genetic Piece in Cancer Pathophysiology and Other Complex Diseases
por: Audia, Salvatore, et al.
Publicado: (2023)

RANBP1, a member of the nuclear-cytoplasmic trafficking-regulator complex, is the terminal-striking point of the SGK1-dependent Th17(+) pathological differentiation
por: Brescia, Carolina, et al.
Publicado: (2023)

Germline Testing in a Cohort of Patients at High Risk of Hereditary Cancer Predisposition Syndromes: First Two-Year Results from South Italy
por: Paduano, Francesco, et al.
Publicado: (2022)

The Variant p.Ala84Pro Is Causative of X-Linked Hypophosphatemic Rickets: Possible Relationship with Burosumab Swinging Response in Adults
por: Zagari, Maria Carmela, et al.
Publicado: (2022)

Th17-Gene Expression Profile in Patients with Chronic Venous Disease and Venous Ulcers: Genetic Modulations and Preliminary Clinical Evidence
por: Amato, Rosario, et al.
Publicado: (2022)

Inhibition of serum- and glucocorticoid-induced kinase 1 ameliorates hydrocephalus in preclinical models
por: Hochstetler, Alexandra, et al.
Publicado: (2023)

In Preclinical Model of Ovarian Cancer, the SGK1 Inhibitor SI113 Counteracts the Development of Paclitaxel Resistance and Restores Drug Sensitivity
por: D'Antona, Lucia, et al.
Publicado: (2019)

SGK1 affects RAN/RANBP1/RANGAP1 via SP1 to play a critical role in pre-miRNA nuclear export: a new route of epigenomic regulation
por: Dattilo, Vincenzo, et al.
Publicado: (2017)

Li–Fraumeni Syndrome: Mutation of TP53 Is a Biomarker of Hereditary Predisposition to Tumor: New Insights and Advances in the Treatment
por: Rocca, Valentina, et al.
Publicado: (2022)

Consideration of Kinase Inhibitors for the Treatment of Hydrocephalus
por: Blazer-Yost, Bonnie L.
Publicado: (2023)

The human asparaginase enzyme (ASPG) inhibits growth in leukemic cells
por: Belviso, Stefania, et al.
Publicado: (2017)

7q35 Microdeletion and 15q13.3 and Xp22.33 Microduplications in a Patient with Severe Myoclonic Epilepsy, Microcephaly, Dysmorphisms, Severe Psychomotor Delay and Intellectual Disability
por: Paduano, Francesco, et al.
Publicado: (2020)

Case Report: Identification of a Novel Pathogenic Germline TP53 Variant in a Family With Li–Fraumeni Syndrome
por: Paduano, Francesco, et al.
Publicado: (2021)

Preclinical model in HCC: the SGK1 kinase inhibitor SI113 blocks tumor progression in vitro and in vivo and synergizes with radiotherapy
por: Talarico, Cristina, et al.
Publicado: (2015)

A Familial Form of Epidermolysis Bullosa Simplex Associated with a Pathogenic Variant in KRT5
por: Paduano, Francesco, et al.
Publicado: (2021)

New SLC12A3 disease causative mutation of Gitelman’s syndrome
por: Grillone, Teresa, et al.
Publicado: (2016)

A Novel Splicing Variant of COL2A1 in a Fetus with Achondrogenesis Type II: Interpretation of Pathogenicity of In-Frame Deletions
por: Bruni, Valentina, et al.
Publicado: (2021)

SI113, a SGK1 inhibitor, potentiates the effects of radiotherapy, modulates the response to oxidative stress and induces cytotoxic autophagy in human glioblastoma multiforme cells
por: Talarico, Cristina, et al.
Publicado: (2016)

The Emerging Role of SGK1 (Serum- and Glucocorticoid-Regulated Kinase 1) in Major Depressive Disorder: Hypothesis and Mechanisms
por: Dattilo, Vincenzo, et al.
Publicado: (2020)

PPARγ Agonists: Blood Pressure and Edema
por: Blazer-Yost, Bonnie L.
Publicado: (2010)

Determination of SGK1 mRNA in non-small cell lung cancer samples underlines high expression in squamous cell carcinomas
por: Abbruzzese, Claudia, et al.
Publicado: (2012)

The sodium-phosphate co-transporter SLC34A2, and pulmonary alveolar microlithiasis: Presentation of an inbred family and a novel truncating mutation in exon 3
por: Vismara, Marco Favio Michele, et al.
Publicado: (2015)

A novel ABCC6 variant causative of pseudoxanthoma elasticum
por: Contrò, Gianluca, et al.
Publicado: (2019)

A cryptic balanced translocation (5;17), a puzzle revealed through a critical evaluation of the pedigree and a FISH focused on candidate loci suggested by the phenotype
por: Primerano, A., et al.
Publicado: (2015)

Hydrocephalus: historical analysis and considerations for treatment
por: Hochstetler, Alexandra, et al.
Publicado: (2022)

From genetic correlations of Alzheimer’s disease to classification with artificial neural network models
por: Cava, Claudia, et al.
Publicado: (2023)

Consequences of exposure to pollutants on respiratory health: From genetic correlations to causal relationships
por: D’Antona, Salvatore, et al.
Publicado: (2022)

International Workshop on Evolutionary Links in the Zoo of Interacting Binaries
por: D'Antona, F
Publicado: (1993)

Physiological aspects of muscular adaptations to training translated to neuromuscular diseases
por: BERARDINELLI, ANGELA, et al.
Publicado: (2019)

Unfolding tyrosine kinase inhibitor sensitivity in chronic myeloid leukemia
por: Perrotti, Danilo, et al.
Publicado: (2012)

Tyrosine Kinase Inhibitors and Pregnancy
por: Abruzzese, Elisabetta, et al.
Publicado: (2014)

The Role of MicroRNAs in Cancer Susceptibility
por: Iuliano, Rodolfo, et al.
Publicado: (2013)

Cushing’s disease: adrenal steroidogenesis inhibitors
por: Pivonello, Rosario, et al.
Publicado: (2022)

Bioinformatic Analysis of Differential Protein Expression in Calu-3 Cells Exposed to Carbon Nanotubes
por: Li, Pin, et al.
Publicado: (2013)

Phenome-wide genetic-correlation analysis and genetically informed causal inference of amyotrophic lateral sclerosis
por: D’Antona, Salvatore, et al.
Publicado: (2023)

Digital signal processing for measurement systems: theory and applications
por: D'Antona, Gabriele, et al.
Publicado: (2006)

Identifying and managing refractory migraine: barriers and opportunities?
por: D’Antona, Linda, et al.
Publicado: (2019)

Experimental Results of Partial Discharge Localization in Bounded Domains
por: Perfetto, Luca, et al.
Publicado: (2021)

Editorial: Insights in exercise physiology: 2021
por: D'Antona, Giuseppe, et al.
Publicado: (2022)

The kinase inhibitor SI113 induces autophagy and synergizes with quinacrine in hindering the growth of human glioblastoma multiforme cells
por: Matteoni, Silvia, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_s6i4me1amfbaphnsncj1lgns52