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Mouse Models of Mineral Bone Disorders Associated with Chronic Kidney Disease
Patients with chronic kidney disease (CKD) inevitably develop mineral and bone disorders (CKD–MBD), which negatively impact their survival and quality of life. For a better understanding of underlying pathophysiology and identification of novel therapeutic approaches, mouse models are essential. CKD...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10048881/ https://www.ncbi.nlm.nih.gov/pubmed/36982400 http://dx.doi.org/10.3390/ijms24065325 |
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author | Zaloszyc, Ariane Bernardor, Julie Bacchetta, Justine Laverny, Gilles Schmitt, Claus Peter |
author_facet | Zaloszyc, Ariane Bernardor, Julie Bacchetta, Justine Laverny, Gilles Schmitt, Claus Peter |
author_sort | Zaloszyc, Ariane |
collection | PubMed |
description | Patients with chronic kidney disease (CKD) inevitably develop mineral and bone disorders (CKD–MBD), which negatively impact their survival and quality of life. For a better understanding of underlying pathophysiology and identification of novel therapeutic approaches, mouse models are essential. CKD can be induced by surgical reduction of a functional kidney mass, by nephrotoxic compounds and by genetic engineering specifically interfering with kidney development. These models develop a large range of bone diseases, recapitulating different types of human CKD–MBD and associated sequelae, including vascular calcifications. Bones are usually studied by quantitative histomorphometry, immunohistochemistry and micro-CT, but alternative strategies have emerged, such as longitudinal in vivo osteoblast activity quantification by tracer scintigraphy. The results gained from the CKD–MBD mouse models are consistent with clinical observations and have provided significant knowledge on specific pathomechanisms, bone properties and potential novel therapeutic strategies. This review discusses available mouse models to study bone disease in CKD. |
format | Online Article Text |
id | pubmed-10048881 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100488812023-03-29 Mouse Models of Mineral Bone Disorders Associated with Chronic Kidney Disease Zaloszyc, Ariane Bernardor, Julie Bacchetta, Justine Laverny, Gilles Schmitt, Claus Peter Int J Mol Sci Review Patients with chronic kidney disease (CKD) inevitably develop mineral and bone disorders (CKD–MBD), which negatively impact their survival and quality of life. For a better understanding of underlying pathophysiology and identification of novel therapeutic approaches, mouse models are essential. CKD can be induced by surgical reduction of a functional kidney mass, by nephrotoxic compounds and by genetic engineering specifically interfering with kidney development. These models develop a large range of bone diseases, recapitulating different types of human CKD–MBD and associated sequelae, including vascular calcifications. Bones are usually studied by quantitative histomorphometry, immunohistochemistry and micro-CT, but alternative strategies have emerged, such as longitudinal in vivo osteoblast activity quantification by tracer scintigraphy. The results gained from the CKD–MBD mouse models are consistent with clinical observations and have provided significant knowledge on specific pathomechanisms, bone properties and potential novel therapeutic strategies. This review discusses available mouse models to study bone disease in CKD. MDPI 2023-03-10 /pmc/articles/PMC10048881/ /pubmed/36982400 http://dx.doi.org/10.3390/ijms24065325 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Zaloszyc, Ariane Bernardor, Julie Bacchetta, Justine Laverny, Gilles Schmitt, Claus Peter Mouse Models of Mineral Bone Disorders Associated with Chronic Kidney Disease |
title | Mouse Models of Mineral Bone Disorders Associated with Chronic Kidney Disease |
title_full | Mouse Models of Mineral Bone Disorders Associated with Chronic Kidney Disease |
title_fullStr | Mouse Models of Mineral Bone Disorders Associated with Chronic Kidney Disease |
title_full_unstemmed | Mouse Models of Mineral Bone Disorders Associated with Chronic Kidney Disease |
title_short | Mouse Models of Mineral Bone Disorders Associated with Chronic Kidney Disease |
title_sort | mouse models of mineral bone disorders associated with chronic kidney disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10048881/ https://www.ncbi.nlm.nih.gov/pubmed/36982400 http://dx.doi.org/10.3390/ijms24065325 |
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