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Identification of CD114 Membrane Receptors as a Molecular Target in Medulloblastomas
Medulloblastomas are the most common solid tumors in children, accounting for 8–30% of pediatric brain cancers. It is a high-grade tumor with aggressive behavior and a typically b poor prognosis. Its treatment includes surgery, chemotherapy, and radiotherapy, and presents high morbidity. Significant...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10048885/ https://www.ncbi.nlm.nih.gov/pubmed/36982406 http://dx.doi.org/10.3390/ijms24065331 |
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author | Monteiro, Jander Moreira Reis Ramos, Jaqueline Isadora Teixeira e Sousa, Ian Bighetti-Trevisan, Rayana Longo Ribas Filho, Jurandir Marcondes Isolan, Gustavo Rassier |
author_facet | Monteiro, Jander Moreira Reis Ramos, Jaqueline Isadora Teixeira e Sousa, Ian Bighetti-Trevisan, Rayana Longo Ribas Filho, Jurandir Marcondes Isolan, Gustavo Rassier |
author_sort | Monteiro, Jander Moreira |
collection | PubMed |
description | Medulloblastomas are the most common solid tumors in children, accounting for 8–30% of pediatric brain cancers. It is a high-grade tumor with aggressive behavior and a typically b poor prognosis. Its treatment includes surgery, chemotherapy, and radiotherapy, and presents high morbidity. Significant clinical, genetic, and prognostic differences exist between its four molecular subgroups: WNT, SHH, Group 3, and Group 4. Many studies seek to develop new chemotherapeutic agents for medulloblastomas through the identification of genes whose expressions are new molecular targets for drugs, such as membrane receptors associated with cell replication. This study aimed to assess the association of CD114 expression with mortality in patients with medulloblastoma. Databases from the Medulloblastoma Advanced Genomics International Consortium (MAGIC) were analyzed, focusing on the expression of the CD114 membrane receptor in different molecular types and its possible association with mortality. Our findings showed different CD114 expressions between Group 3 and other molecular groups, as well as between the molecular subtypes SHH γ and Group 3 α and Group 3 β. There was no statistically significant difference between the other groups and subtypes. Regarding mortality, this study did not find statistical significance in the association between low and high CD114 expressions and mortality. Medulloblastoma is a heterogeneous disease with many subtype variations of its genetic and intracellular signaling pathways. Similarly to this study, which could not demonstrate different CD114 membrane receptor expression patterns between groups, others who sought to associate CD114 expression with mortality in other types of cancer failed to establish a direct association. Since many indications point to the relation of this gene with cancer stem cells (CSCs), it may be part of a more extensive cellular signaling pathway with an eventual association with tumor recurrence. This study found no direct relationship between CD114 expression and mortality in patients with medulloblastoma. Further studies are needed on the intracellular signaling pathways associated with this receptor and its gene (the CSF3R). |
format | Online Article Text |
id | pubmed-10048885 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100488852023-03-29 Identification of CD114 Membrane Receptors as a Molecular Target in Medulloblastomas Monteiro, Jander Moreira Reis Ramos, Jaqueline Isadora Teixeira e Sousa, Ian Bighetti-Trevisan, Rayana Longo Ribas Filho, Jurandir Marcondes Isolan, Gustavo Rassier Int J Mol Sci Article Medulloblastomas are the most common solid tumors in children, accounting for 8–30% of pediatric brain cancers. It is a high-grade tumor with aggressive behavior and a typically b poor prognosis. Its treatment includes surgery, chemotherapy, and radiotherapy, and presents high morbidity. Significant clinical, genetic, and prognostic differences exist between its four molecular subgroups: WNT, SHH, Group 3, and Group 4. Many studies seek to develop new chemotherapeutic agents for medulloblastomas through the identification of genes whose expressions are new molecular targets for drugs, such as membrane receptors associated with cell replication. This study aimed to assess the association of CD114 expression with mortality in patients with medulloblastoma. Databases from the Medulloblastoma Advanced Genomics International Consortium (MAGIC) were analyzed, focusing on the expression of the CD114 membrane receptor in different molecular types and its possible association with mortality. Our findings showed different CD114 expressions between Group 3 and other molecular groups, as well as between the molecular subtypes SHH γ and Group 3 α and Group 3 β. There was no statistically significant difference between the other groups and subtypes. Regarding mortality, this study did not find statistical significance in the association between low and high CD114 expressions and mortality. Medulloblastoma is a heterogeneous disease with many subtype variations of its genetic and intracellular signaling pathways. Similarly to this study, which could not demonstrate different CD114 membrane receptor expression patterns between groups, others who sought to associate CD114 expression with mortality in other types of cancer failed to establish a direct association. Since many indications point to the relation of this gene with cancer stem cells (CSCs), it may be part of a more extensive cellular signaling pathway with an eventual association with tumor recurrence. This study found no direct relationship between CD114 expression and mortality in patients with medulloblastoma. Further studies are needed on the intracellular signaling pathways associated with this receptor and its gene (the CSF3R). MDPI 2023-03-10 /pmc/articles/PMC10048885/ /pubmed/36982406 http://dx.doi.org/10.3390/ijms24065331 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Monteiro, Jander Moreira Reis Ramos, Jaqueline Isadora Teixeira e Sousa, Ian Bighetti-Trevisan, Rayana Longo Ribas Filho, Jurandir Marcondes Isolan, Gustavo Rassier Identification of CD114 Membrane Receptors as a Molecular Target in Medulloblastomas |
title | Identification of CD114 Membrane Receptors as a Molecular Target in Medulloblastomas |
title_full | Identification of CD114 Membrane Receptors as a Molecular Target in Medulloblastomas |
title_fullStr | Identification of CD114 Membrane Receptors as a Molecular Target in Medulloblastomas |
title_full_unstemmed | Identification of CD114 Membrane Receptors as a Molecular Target in Medulloblastomas |
title_short | Identification of CD114 Membrane Receptors as a Molecular Target in Medulloblastomas |
title_sort | identification of cd114 membrane receptors as a molecular target in medulloblastomas |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10048885/ https://www.ncbi.nlm.nih.gov/pubmed/36982406 http://dx.doi.org/10.3390/ijms24065331 |
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