High Glucose Promotes Inflammation and Weakens Placental Defenses against E. coli and S. agalactiae Infection: Protective Role of Insulin and Metformin

Placentas from gestational diabetes mellitus (GDM) patients undergo significant metabolic and immunologic adaptations due to hyperglycemia, which results in an exacerbated synthesis of proinflammatory cytokines and an increased risk for infections. Insulin or metformin are clinically indicated for t...

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Detalles Bibliográficos
Autores principales: Jiménez-Escutia, Rodrigo, Vargas-Alcantar, Donovan, Flores-Espinosa, Pilar, Helguera-Repetto, Addy Cecilia, Villavicencio-Carrisoza, Oscar, Mancilla-Herrera, Ismael, Irles, Claudine, Torres-Ramos, Yessica Dorin, Valdespino-Vazquez, María Yolotzin, Velázquez-Sánchez, Pilar, Zamora-Escudero, Rodrigo, Islas-López, Marcela, Carranco-Salinas, Caridad, Díaz, Lorenza, Zaga-Clavellina, Verónica, Olmos-Ortiz, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10048930/
https://www.ncbi.nlm.nih.gov/pubmed/36982317
http://dx.doi.org/10.3390/ijms24065243

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