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Influence of Environmental Exposure to Steel Waste on Endocrine Dysregulation and PER3 Gene Polymorphisms
Objective: To evaluate the association between environmental exposure to the following chemical substances: cadmium (Cd), lead (Pb), nickel (Ni), manganese (Mn), benzene (BZN), and toluene (TLN), and Period Circadian Regulator 3 (PER3) gene variable number of tandem repeats (VNTR) polymorphisms, acc...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10049198/ https://www.ncbi.nlm.nih.gov/pubmed/36981669 http://dx.doi.org/10.3390/ijerph20064760 |
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author | Coutinho, Gilvania Barreto Feitosa Moreira, Maria de Fátima Ramos Fischer, Frida Marina dos Santos, Maria Carolina Reis Feitosa, Lucas Ferreira de Azevedo, Sayonara Vieira Borges, Renato Marçullo Nascimento-Sales, Michelle Christoffolete, Marcelo Augusto Santa-Marinha, Marden Samir Valente, Daniel Teixeira, Liliane Reis |
author_facet | Coutinho, Gilvania Barreto Feitosa Moreira, Maria de Fátima Ramos Fischer, Frida Marina dos Santos, Maria Carolina Reis Feitosa, Lucas Ferreira de Azevedo, Sayonara Vieira Borges, Renato Marçullo Nascimento-Sales, Michelle Christoffolete, Marcelo Augusto Santa-Marinha, Marden Samir Valente, Daniel Teixeira, Liliane Reis |
author_sort | Coutinho, Gilvania Barreto Feitosa |
collection | PubMed |
description | Objective: To evaluate the association between environmental exposure to the following chemical substances: cadmium (Cd), lead (Pb), nickel (Ni), manganese (Mn), benzene (BZN), and toluene (TLN), and Period Circadian Regulator 3 (PER3) gene variable number of tandem repeats (VNTR) polymorphisms, according to chronotype in a population living in a steel residue-contaminated area. Methods: This assessment comprises a study conducted from 2017 to 2019 with 159 participants who completed health, work, and Pittsburgh sleep scale questionnaires. Cd, Pb, Ni, Mn, BZN, and TLN concentrations in blood and urine were determined by Graphite Furnace Atomic Absorption Spectrometry (GFAAS) and Headspace Gas Chromatography (GC), and genotyping was carried out using Polymerase Chain Reaction (PCR). Results: A total of 47% of the participants were afternoon chronotype, 42% were indifferent, and 11% were morning chronotype. Insomnia and excessive sleepiness were associated with the indifferent chronotype, while higher urinary manganese levels were associated with the morning chronotype (Kruskal–Wallis chi-square = 9.16; p < 0.01). In turn, the evening chronotype was associated with poorer sleep quality, higher lead levels in blood, and BZN and TLN levels in urine (χ(2) = 11.20; p < 0.01) in non-occupationally exposed individuals (χ(2) = 6.98; p < 0.01) as well as the highest BZN (χ(2) = 9.66; p < 0.01) and TLN (χ(2) = 5.71; p < 0.01) levels detected in residents from the influence zone 2 (far from the slag). Conclusion: Mn, Pb, benzene, and toluene contaminants may have influenced the different chronotypes found in the steel residue-exposed population. |
format | Online Article Text |
id | pubmed-10049198 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100491982023-03-29 Influence of Environmental Exposure to Steel Waste on Endocrine Dysregulation and PER3 Gene Polymorphisms Coutinho, Gilvania Barreto Feitosa Moreira, Maria de Fátima Ramos Fischer, Frida Marina dos Santos, Maria Carolina Reis Feitosa, Lucas Ferreira de Azevedo, Sayonara Vieira Borges, Renato Marçullo Nascimento-Sales, Michelle Christoffolete, Marcelo Augusto Santa-Marinha, Marden Samir Valente, Daniel Teixeira, Liliane Reis Int J Environ Res Public Health Article Objective: To evaluate the association between environmental exposure to the following chemical substances: cadmium (Cd), lead (Pb), nickel (Ni), manganese (Mn), benzene (BZN), and toluene (TLN), and Period Circadian Regulator 3 (PER3) gene variable number of tandem repeats (VNTR) polymorphisms, according to chronotype in a population living in a steel residue-contaminated area. Methods: This assessment comprises a study conducted from 2017 to 2019 with 159 participants who completed health, work, and Pittsburgh sleep scale questionnaires. Cd, Pb, Ni, Mn, BZN, and TLN concentrations in blood and urine were determined by Graphite Furnace Atomic Absorption Spectrometry (GFAAS) and Headspace Gas Chromatography (GC), and genotyping was carried out using Polymerase Chain Reaction (PCR). Results: A total of 47% of the participants were afternoon chronotype, 42% were indifferent, and 11% were morning chronotype. Insomnia and excessive sleepiness were associated with the indifferent chronotype, while higher urinary manganese levels were associated with the morning chronotype (Kruskal–Wallis chi-square = 9.16; p < 0.01). In turn, the evening chronotype was associated with poorer sleep quality, higher lead levels in blood, and BZN and TLN levels in urine (χ(2) = 11.20; p < 0.01) in non-occupationally exposed individuals (χ(2) = 6.98; p < 0.01) as well as the highest BZN (χ(2) = 9.66; p < 0.01) and TLN (χ(2) = 5.71; p < 0.01) levels detected in residents from the influence zone 2 (far from the slag). Conclusion: Mn, Pb, benzene, and toluene contaminants may have influenced the different chronotypes found in the steel residue-exposed population. MDPI 2023-03-08 /pmc/articles/PMC10049198/ /pubmed/36981669 http://dx.doi.org/10.3390/ijerph20064760 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Coutinho, Gilvania Barreto Feitosa Moreira, Maria de Fátima Ramos Fischer, Frida Marina dos Santos, Maria Carolina Reis Feitosa, Lucas Ferreira de Azevedo, Sayonara Vieira Borges, Renato Marçullo Nascimento-Sales, Michelle Christoffolete, Marcelo Augusto Santa-Marinha, Marden Samir Valente, Daniel Teixeira, Liliane Reis Influence of Environmental Exposure to Steel Waste on Endocrine Dysregulation and PER3 Gene Polymorphisms |
title | Influence of Environmental Exposure to Steel Waste on Endocrine Dysregulation and PER3 Gene Polymorphisms |
title_full | Influence of Environmental Exposure to Steel Waste on Endocrine Dysregulation and PER3 Gene Polymorphisms |
title_fullStr | Influence of Environmental Exposure to Steel Waste on Endocrine Dysregulation and PER3 Gene Polymorphisms |
title_full_unstemmed | Influence of Environmental Exposure to Steel Waste on Endocrine Dysregulation and PER3 Gene Polymorphisms |
title_short | Influence of Environmental Exposure to Steel Waste on Endocrine Dysregulation and PER3 Gene Polymorphisms |
title_sort | influence of environmental exposure to steel waste on endocrine dysregulation and per3 gene polymorphisms |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10049198/ https://www.ncbi.nlm.nih.gov/pubmed/36981669 http://dx.doi.org/10.3390/ijerph20064760 |
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