Cargando…

Influence of Environmental Exposure to Steel Waste on Endocrine Dysregulation and PER3 Gene Polymorphisms

Objective: To evaluate the association between environmental exposure to the following chemical substances: cadmium (Cd), lead (Pb), nickel (Ni), manganese (Mn), benzene (BZN), and toluene (TLN), and Period Circadian Regulator 3 (PER3) gene variable number of tandem repeats (VNTR) polymorphisms, acc...

Descripción completa

Detalles Bibliográficos
Autores principales: Coutinho, Gilvania Barreto Feitosa, Moreira, Maria de Fátima Ramos, Fischer, Frida Marina, dos Santos, Maria Carolina Reis, Feitosa, Lucas Ferreira, de Azevedo, Sayonara Vieira, Borges, Renato Marçullo, Nascimento-Sales, Michelle, Christoffolete, Marcelo Augusto, Santa-Marinha, Marden Samir, Valente, Daniel, Teixeira, Liliane Reis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10049198/
https://www.ncbi.nlm.nih.gov/pubmed/36981669
http://dx.doi.org/10.3390/ijerph20064760
_version_ 1785014395162591232
author Coutinho, Gilvania Barreto Feitosa
Moreira, Maria de Fátima Ramos
Fischer, Frida Marina
dos Santos, Maria Carolina Reis
Feitosa, Lucas Ferreira
de Azevedo, Sayonara Vieira
Borges, Renato Marçullo
Nascimento-Sales, Michelle
Christoffolete, Marcelo Augusto
Santa-Marinha, Marden Samir
Valente, Daniel
Teixeira, Liliane Reis
author_facet Coutinho, Gilvania Barreto Feitosa
Moreira, Maria de Fátima Ramos
Fischer, Frida Marina
dos Santos, Maria Carolina Reis
Feitosa, Lucas Ferreira
de Azevedo, Sayonara Vieira
Borges, Renato Marçullo
Nascimento-Sales, Michelle
Christoffolete, Marcelo Augusto
Santa-Marinha, Marden Samir
Valente, Daniel
Teixeira, Liliane Reis
author_sort Coutinho, Gilvania Barreto Feitosa
collection PubMed
description Objective: To evaluate the association between environmental exposure to the following chemical substances: cadmium (Cd), lead (Pb), nickel (Ni), manganese (Mn), benzene (BZN), and toluene (TLN), and Period Circadian Regulator 3 (PER3) gene variable number of tandem repeats (VNTR) polymorphisms, according to chronotype in a population living in a steel residue-contaminated area. Methods: This assessment comprises a study conducted from 2017 to 2019 with 159 participants who completed health, work, and Pittsburgh sleep scale questionnaires. Cd, Pb, Ni, Mn, BZN, and TLN concentrations in blood and urine were determined by Graphite Furnace Atomic Absorption Spectrometry (GFAAS) and Headspace Gas Chromatography (GC), and genotyping was carried out using Polymerase Chain Reaction (PCR). Results: A total of 47% of the participants were afternoon chronotype, 42% were indifferent, and 11% were morning chronotype. Insomnia and excessive sleepiness were associated with the indifferent chronotype, while higher urinary manganese levels were associated with the morning chronotype (Kruskal–Wallis chi-square = 9.16; p < 0.01). In turn, the evening chronotype was associated with poorer sleep quality, higher lead levels in blood, and BZN and TLN levels in urine (χ(2) = 11.20; p < 0.01) in non-occupationally exposed individuals (χ(2) = 6.98; p < 0.01) as well as the highest BZN (χ(2) = 9.66; p < 0.01) and TLN (χ(2) = 5.71; p < 0.01) levels detected in residents from the influence zone 2 (far from the slag). Conclusion: Mn, Pb, benzene, and toluene contaminants may have influenced the different chronotypes found in the steel residue-exposed population.
format Online
Article
Text
id pubmed-10049198
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-100491982023-03-29 Influence of Environmental Exposure to Steel Waste on Endocrine Dysregulation and PER3 Gene Polymorphisms Coutinho, Gilvania Barreto Feitosa Moreira, Maria de Fátima Ramos Fischer, Frida Marina dos Santos, Maria Carolina Reis Feitosa, Lucas Ferreira de Azevedo, Sayonara Vieira Borges, Renato Marçullo Nascimento-Sales, Michelle Christoffolete, Marcelo Augusto Santa-Marinha, Marden Samir Valente, Daniel Teixeira, Liliane Reis Int J Environ Res Public Health Article Objective: To evaluate the association between environmental exposure to the following chemical substances: cadmium (Cd), lead (Pb), nickel (Ni), manganese (Mn), benzene (BZN), and toluene (TLN), and Period Circadian Regulator 3 (PER3) gene variable number of tandem repeats (VNTR) polymorphisms, according to chronotype in a population living in a steel residue-contaminated area. Methods: This assessment comprises a study conducted from 2017 to 2019 with 159 participants who completed health, work, and Pittsburgh sleep scale questionnaires. Cd, Pb, Ni, Mn, BZN, and TLN concentrations in blood and urine were determined by Graphite Furnace Atomic Absorption Spectrometry (GFAAS) and Headspace Gas Chromatography (GC), and genotyping was carried out using Polymerase Chain Reaction (PCR). Results: A total of 47% of the participants were afternoon chronotype, 42% were indifferent, and 11% were morning chronotype. Insomnia and excessive sleepiness were associated with the indifferent chronotype, while higher urinary manganese levels were associated with the morning chronotype (Kruskal–Wallis chi-square = 9.16; p < 0.01). In turn, the evening chronotype was associated with poorer sleep quality, higher lead levels in blood, and BZN and TLN levels in urine (χ(2) = 11.20; p < 0.01) in non-occupationally exposed individuals (χ(2) = 6.98; p < 0.01) as well as the highest BZN (χ(2) = 9.66; p < 0.01) and TLN (χ(2) = 5.71; p < 0.01) levels detected in residents from the influence zone 2 (far from the slag). Conclusion: Mn, Pb, benzene, and toluene contaminants may have influenced the different chronotypes found in the steel residue-exposed population. MDPI 2023-03-08 /pmc/articles/PMC10049198/ /pubmed/36981669 http://dx.doi.org/10.3390/ijerph20064760 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Coutinho, Gilvania Barreto Feitosa
Moreira, Maria de Fátima Ramos
Fischer, Frida Marina
dos Santos, Maria Carolina Reis
Feitosa, Lucas Ferreira
de Azevedo, Sayonara Vieira
Borges, Renato Marçullo
Nascimento-Sales, Michelle
Christoffolete, Marcelo Augusto
Santa-Marinha, Marden Samir
Valente, Daniel
Teixeira, Liliane Reis
Influence of Environmental Exposure to Steel Waste on Endocrine Dysregulation and PER3 Gene Polymorphisms
title Influence of Environmental Exposure to Steel Waste on Endocrine Dysregulation and PER3 Gene Polymorphisms
title_full Influence of Environmental Exposure to Steel Waste on Endocrine Dysregulation and PER3 Gene Polymorphisms
title_fullStr Influence of Environmental Exposure to Steel Waste on Endocrine Dysregulation and PER3 Gene Polymorphisms
title_full_unstemmed Influence of Environmental Exposure to Steel Waste on Endocrine Dysregulation and PER3 Gene Polymorphisms
title_short Influence of Environmental Exposure to Steel Waste on Endocrine Dysregulation and PER3 Gene Polymorphisms
title_sort influence of environmental exposure to steel waste on endocrine dysregulation and per3 gene polymorphisms
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10049198/
https://www.ncbi.nlm.nih.gov/pubmed/36981669
http://dx.doi.org/10.3390/ijerph20064760
work_keys_str_mv AT coutinhogilvaniabarretofeitosa influenceofenvironmentalexposuretosteelwasteonendocrinedysregulationandper3genepolymorphisms
AT moreiramariadefatimaramos influenceofenvironmentalexposuretosteelwasteonendocrinedysregulationandper3genepolymorphisms
AT fischerfridamarina influenceofenvironmentalexposuretosteelwasteonendocrinedysregulationandper3genepolymorphisms
AT dossantosmariacarolinareis influenceofenvironmentalexposuretosteelwasteonendocrinedysregulationandper3genepolymorphisms
AT feitosalucasferreira influenceofenvironmentalexposuretosteelwasteonendocrinedysregulationandper3genepolymorphisms
AT deazevedosayonaravieira influenceofenvironmentalexposuretosteelwasteonendocrinedysregulationandper3genepolymorphisms
AT borgesrenatomarcullo influenceofenvironmentalexposuretosteelwasteonendocrinedysregulationandper3genepolymorphisms
AT nascimentosalesmichelle influenceofenvironmentalexposuretosteelwasteonendocrinedysregulationandper3genepolymorphisms
AT christoffoletemarceloaugusto influenceofenvironmentalexposuretosteelwasteonendocrinedysregulationandper3genepolymorphisms
AT santamarinhamardensamir influenceofenvironmentalexposuretosteelwasteonendocrinedysregulationandper3genepolymorphisms
AT valentedaniel influenceofenvironmentalexposuretosteelwasteonendocrinedysregulationandper3genepolymorphisms
AT teixeiralilianereis influenceofenvironmentalexposuretosteelwasteonendocrinedysregulationandper3genepolymorphisms