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The Role of Lubricin, Irisin and Exercise in the Prevention and Treatment of Osteoarthritis

Osteoarthritis is a chronic degenerative musculoskeletal disease that worsens with age and is defined by pathological alterations in joint components. All clinical treatment recommendations for osteoarthritis promote exercise, although precise molecular pathways are unclear. The purpose of this stud...

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Autores principales: Roggio, Federico, Petrigna, Luca, Trovato, Bruno, Di Rosa, Michelino, Musumeci, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10049370/
https://www.ncbi.nlm.nih.gov/pubmed/36982198
http://dx.doi.org/10.3390/ijms24065126
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author Roggio, Federico
Petrigna, Luca
Trovato, Bruno
Di Rosa, Michelino
Musumeci, Giuseppe
author_facet Roggio, Federico
Petrigna, Luca
Trovato, Bruno
Di Rosa, Michelino
Musumeci, Giuseppe
author_sort Roggio, Federico
collection PubMed
description Osteoarthritis is a chronic degenerative musculoskeletal disease that worsens with age and is defined by pathological alterations in joint components. All clinical treatment recommendations for osteoarthritis promote exercise, although precise molecular pathways are unclear. The purpose of this study was to critically analyze the research on lubricin and irisin and how they relate to healthy and diseased joint tissue. Our research focused specifically on exercise strategies and offered new perspectives for future potential osteoarthritis treatment plans. Although lubricin and irisin have only recently been discovered, there is evidence that they have an impact on cartilage homeostasis. A crucial component of cartilage lubrication and integrity, lubricin is a surface-active mucinous glycoprotein released by the synovial joint. Its expression increases with joint movement. In healthy joints, lubricin molecules cover the cartilage surface to lubricate the boundary of the joint and inhibit protein and cell attachment. Patients with joint trauma, inflammatory arthritis, or genetically mediated lubricin deficiency, who do not produce enough lubricin to protect the articular cartilage, develop arthropathy. Irisin, sometimes known as the “sports hormone”, is a myokine secreted primarily by skeletal muscle. It is a physiologically active protein that can enter the circulation as an endocrine factor, and its synthesis and secretion are primarily triggered by exercise-induced muscle contraction. We searched PubMed, Web of Science, Google Scholar, and Scopus using the appropriate keywords to identify the most recent research. The studies considered advance our knowledge of the role that exercise plays in the fight against osteoarthritis, serve as a valuable resource, and support the advancement of osteoarthritis prevention and therapy.
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spelling pubmed-100493702023-03-29 The Role of Lubricin, Irisin and Exercise in the Prevention and Treatment of Osteoarthritis Roggio, Federico Petrigna, Luca Trovato, Bruno Di Rosa, Michelino Musumeci, Giuseppe Int J Mol Sci Review Osteoarthritis is a chronic degenerative musculoskeletal disease that worsens with age and is defined by pathological alterations in joint components. All clinical treatment recommendations for osteoarthritis promote exercise, although precise molecular pathways are unclear. The purpose of this study was to critically analyze the research on lubricin and irisin and how they relate to healthy and diseased joint tissue. Our research focused specifically on exercise strategies and offered new perspectives for future potential osteoarthritis treatment plans. Although lubricin and irisin have only recently been discovered, there is evidence that they have an impact on cartilage homeostasis. A crucial component of cartilage lubrication and integrity, lubricin is a surface-active mucinous glycoprotein released by the synovial joint. Its expression increases with joint movement. In healthy joints, lubricin molecules cover the cartilage surface to lubricate the boundary of the joint and inhibit protein and cell attachment. Patients with joint trauma, inflammatory arthritis, or genetically mediated lubricin deficiency, who do not produce enough lubricin to protect the articular cartilage, develop arthropathy. Irisin, sometimes known as the “sports hormone”, is a myokine secreted primarily by skeletal muscle. It is a physiologically active protein that can enter the circulation as an endocrine factor, and its synthesis and secretion are primarily triggered by exercise-induced muscle contraction. We searched PubMed, Web of Science, Google Scholar, and Scopus using the appropriate keywords to identify the most recent research. The studies considered advance our knowledge of the role that exercise plays in the fight against osteoarthritis, serve as a valuable resource, and support the advancement of osteoarthritis prevention and therapy. MDPI 2023-03-07 /pmc/articles/PMC10049370/ /pubmed/36982198 http://dx.doi.org/10.3390/ijms24065126 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Roggio, Federico
Petrigna, Luca
Trovato, Bruno
Di Rosa, Michelino
Musumeci, Giuseppe
The Role of Lubricin, Irisin and Exercise in the Prevention and Treatment of Osteoarthritis
title The Role of Lubricin, Irisin and Exercise in the Prevention and Treatment of Osteoarthritis
title_full The Role of Lubricin, Irisin and Exercise in the Prevention and Treatment of Osteoarthritis
title_fullStr The Role of Lubricin, Irisin and Exercise in the Prevention and Treatment of Osteoarthritis
title_full_unstemmed The Role of Lubricin, Irisin and Exercise in the Prevention and Treatment of Osteoarthritis
title_short The Role of Lubricin, Irisin and Exercise in the Prevention and Treatment of Osteoarthritis
title_sort role of lubricin, irisin and exercise in the prevention and treatment of osteoarthritis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10049370/
https://www.ncbi.nlm.nih.gov/pubmed/36982198
http://dx.doi.org/10.3390/ijms24065126
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