The Endothelial Glycocalyx as a Target of Excess Soluble Fms-like Tyrosine Kinase-1

Soluble fms-like tyrosine kinase-1 (sFlt-1) is a secreted protein that binds heparan sulfate expressed on the endothelial glycocalyx (eGC). In this paper we analyze how excess sFlt-1 causes conformational changes in the eGC, leading to monocyte adhesion, a key event triggering vascular dysfunction....

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Detalles Bibliográficos
Autores principales: Schulz, Annika, Drost, Carolin C., Hesse, Bettina, Beul, Katrin, Boeckel, Göran R., Lukasz, Alexander, Pavenstädt, Hermann, Brand, Marcus, Di Marco, Giovana S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10049398/
https://www.ncbi.nlm.nih.gov/pubmed/36982455
http://dx.doi.org/10.3390/ijms24065380

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10049398/
https://www.ncbi.nlm.nih.gov/pubmed/36982455
http://dx.doi.org/10.3390/ijms24065380

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