Cargando…

Role of Klotho and AGE/RAGE-Wnt/β-Catenin Signalling Pathway on the Development of Cardiac and Renal Fibrosis in Diabetes

Fibrosis plays an important role in the pathogenesis of long-term diabetic complications and contributes to the development of cardiac and renal dysfunction. The aim of this experimental study, performed in a long-term rat model, which resembles type 1 diabetes mellitus, was to investigate the role...

Descripción completa

Detalles Bibliográficos
Autores principales:	Martín-Carro, Beatriz, Martín-Vírgala, Julia, Fernández-Villabrille, Sara, Fernández-Fernández, Alejandra, Pérez-Basterrechea, Marcos, Navarro-González, Juan F., Donate-Correa, Javier, Mora-Fernández, Carmen, Dusso, Adriana S., Carrillo-López, Natalia, Panizo, Sara, Naves-Díaz, Manuel, Fernández-Martín, José L., Cannata-Andía, Jorge B., Alonso-Montes, Cristina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10049403/ https://www.ncbi.nlm.nih.gov/pubmed/36982322 http://dx.doi.org/10.3390/ijms24065241

Ejemplares similares

Serum and Urinary Soluble α-Klotho as Markers of Kidney and Vascular Impairment
por: Martín-Vírgala, Julia, et al.
Publicado: (2023)

Phosphorus May Induce Phenotypic Transdifferentiation of Vascular Smooth Muscle Cells through the Reduction of microRNA-145
por: Fernández-Villabrille, Sara, et al.
Publicado: (2023)

Experimental Models to Study Diabetes Mellitus and Its Complications: Limitations and New Opportunities
por: Martín-Carro, Beatriz, et al.
Publicado: (2023)

MicroRNA-145 and microRNA-486 are potential serum biomarkers for vascular calcification
por: Fernández-Villabrille, Sara, et al.
Publicado: (2023)

Klotho, Oxidative Stress, and Mitochondrial Damage in Kidney Disease
por: Donate-Correa, Javier, et al.
Publicado: (2023)

Fibrosis in Chronic Kidney Disease: Pathogenesis and Consequences
por: Panizo, Sara, et al.
Publicado: (2021)

Redox Metabolism and Vascular Calcification in Chronic Kidney Disease
por: Carrillo-López, Natalia, et al.
Publicado: (2023)

Effects of a Losartan-Antioxidant Hybrid (GGN1231) on Vascular and Cardiac Health in an Experimental Model of Chronic Renal Failure
por: Martínez-Arias, Laura, et al.
Publicado: (2023)

Association of Klotho with Coronary Artery Disease in Subjects with Type 2 Diabetes Mellitus and Preserved Kidney Function: A Case-Control Study
por: Donate-Correa, Javier, et al.
Publicado: (2023)

Klotho as a biomarker of subclinical atherosclerosis in patients with moderate to severe chronic kidney disease
por: Donate-Correa, Javier, et al.
Publicado: (2021)

Influence of Klotho gene polymorphisms on vascular gene expression and its relationship to cardiovascular disease
por: Donate‐Correa, Javier, et al.
Publicado: (2015)

Novel Immune Cell Subsets Exhibit Different Associations With Vascular Outcomes in Chronic Kidney Disease Patients—Identifying Potential Biomarkers
por: Rodríguez-Carrio, Javier, et al.
Publicado: (2021)

Mineral and bone metabolism markers and mortality in diabetic patients on haemodialysis
por: Martín-Carro, Beatriz, et al.
Publicado: (2023)

Vitamin D Treatment Prevents Uremia-Induced Reductions in Aortic microRNA-145 Attenuating Osteogenic Differentiation despite Hyperphosphatemia
por: Carrillo-López, Natalia, et al.
Publicado: (2022)

Association between serum levels of Klotho and inflammatory cytokines in cardiovascular disease: a case-control study
por: Martín-Núñez, Ernesto, et al.
Publicado: (2020)

Klotho, the elusive kidney-derived anti-ageing factor
por: Sanchez-Niño, Maria Dolores, et al.
Publicado: (2019)

The hypercalcaemia of CYP24A1 inactivation: new ways to improve diagnosis and treatment
por: Dusso, Adriana S., et al.
Publicado: (2015)

Slow RNAPII Transcription Elongation Rate, Low Levels of RNAPII Pausing, and Elevated Histone H1 Content at Promoters Associate with Higher m6A Deposition on Nascent mRNAs
por: Gallego, Alicia, et al.
Publicado: (2022)

Pathophysiology of Vascular Calcification and Bone Loss: Linked Disorders of Ageing?
por: Cannata-Andía, Jorge B., et al.
Publicado: (2021)

FGF23 and Klotho Levels are Independently Associated with Diabetic Foot Syndrome in Type 2 Diabetes Mellitus
por: Donate-Correa, Javier, et al.
Publicado: (2019)

A single-oral bolus of 100,000 IU of cholecalciferol at hospital admission did not improve outcomes in the COVID-19 disease: the COVID-VIT-D—a randomised multicentre international clinical trial
por: Cannata-Andía, Jorge B., et al.
Publicado: (2022)

Klotho expression in peripheral blood circulating cells is associated with vascular and systemic inflammation in atherosclerotic vascular disease
por: Martín-Núñez, Ernesto, et al.
Publicado: (2022)

Vitamin D Receptor Polymorphism and DHCR7 Contribute to the Abnormal Interplay Between Vitamin D and Lipid Profile in Rheumatoid Arthritis
por: Rodríguez-Carrio, Javier, et al.
Publicado: (2019)

Associations between Inflammation, Hemoglobin Levels, and Coronary Artery Disease in Non-Albuminuric Subjects with and without Type 2 Diabetes Mellitus
por: Donate-Correa, Javier, et al.
Publicado: (2023)

Inflammatory Cytokines in Diabetic Nephropathy
por: Donate-Correa, Javier, et al.
Publicado: (2015)

Klotho inversely relates with carotid intima- media thickness in atherosclerotic patients with normal renal function (eGFR ≥60 mL/min/1.73m(2)): a proof-of-concept study
por: Donate-Correa, Javier, et al.
Publicado: (2023)

Repurposing drugs for highly prevalent diseases: pentoxifylline, an old drug and a new opportunity for diabetic kidney disease
por: Donate-Correa, Javier, et al.
Publicado: (2022)

Klotho Levels and Their Relationship with Inflammation and Survival among Alcoholic Patients
por: Martín-González, Candelaria, et al.
Publicado: (2022)

Barley-ß-glucans reduce systemic inflammation, renal injury and aortic calcification through ADAM17 and neutral-sphingomyelinase2 inhibition
por: Arcidiacono, Maria Vittoria, et al.
Publicado: (2019)

Biomarkers for Optimization and Personalization of Anti-TNFs in Pediatric Inflammatory Bowel Disease
por: Salvador-Martín, Sara, et al.
Publicado: (2021)

Vitamin D Receptor Deficiency Enhances Wnt/β-Catenin Signaling and Tumor Burden in Colon Cancer
por: Larriba, María Jesús, et al.
Publicado: (2011)

Loss of Klotho contributes to cartilage damage by derepression of canonical Wnt/β-catenin signaling in osteoarthritis mice
por: Gu, Yanqing, et al.
Publicado: (2019)

A subset of low density granulocytes is associated with vascular calcification in chronic kidney disease patients
por: Rodríguez-Carrio, Javier, et al.
Publicado: (2019)

Fibroblast Growth Factor-23-Klotho Axis in Cardiorenal Syndrome: Mediators and Potential Therapeutic Targets
por: Navarro-García, José Alberto, et al.
Publicado: (2021)

Inflammatory Cytokines in Diabetic Kidney Disease: Pathophysiologic and Therapeutic Implications
por: Donate-Correa, Javier, et al.
Publicado: (2021)

Pathophysiological Implications of Imbalances in Fibroblast Growth Factor 23 in the Development of Diabetes
por: Donate-Correa, Javier, et al.
Publicado: (2021)

Partial Genetic Deletion of Klotho Aggravates Cardiac Calcium Mishandling in Acute Kidney Injury
por: González-Lafuente, Laura, et al.
Publicado: (2023)

Focal palmoplantar and gingival keratosis – A rare genodermatoses: Case report
por: Gerber-Mora, Roberto, et al.
Publicado: (2020)

Association of α-klotho with subclinical carotid atherosclerosis in subjects with type 1 diabetes mellitus
por: Castelblanco, Esmeralda, et al.
Publicado: (2022)

Precocious Puberty in Hypothyroidism: Mini-Review of Van Wyk–Grumbach Syndrome
por: Fernandez-Gonzalez, Sara Maria, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_qud061hu5pl84d2l0m9i7ris2i