Aminooxy Click Modification of a Periodate-Oxidized Immunoglobulin G: A General Approach to Antibody–Drug Conjugates with Dye-Mediated Expeditious Stoichiometry Control

A universal approach to the construction of antibody–drug conjugates (ADCs) has been developed. It relies on periodate oxidation of naturally present glycans of immunoglobulin G, followed by oxime ligation and, optionally, copper(I)-catalyzed alkyne-azide cycloaddition for conjugation with a toxic p...

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Detalles Bibliográficos
Autores principales: Sapozhnikova, Ksenia A., Gulyak, Evgeny L., Brylev, Vladimir A., Misyurin, Vsevolod A., Oreshkov, Sergey D., Alexeeva, Anastasiya V., Ryazantsev, Dmitry Yu., Simonova, Maria A., Ryabukhina, Ekaterina V., Popova, Galina P., Tikhonova, Nataliya A., Lyzhko, Natalia A., Barmashov, Alexander E., Misyurin, Andrey V., Ustinov, Alexey V., Alferova, Vera A., Korshun, Vladimir A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10049567/
https://www.ncbi.nlm.nih.gov/pubmed/36982208
http://dx.doi.org/10.3390/ijms24065134

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