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Biomarkers of Migraine: An Integrated Evaluation of Preclinical and Clinical Findings

In recent years, numerous efforts have been made to identify reliable biomarkers useful in migraine diagnosis and progression or associated with the response to a specific treatment. The purpose of this review is to summarize the alleged diagnostic and therapeutic migraine biomarkers found in bioflu...

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Autores principales: Demartini, Chiara, Francavilla, Miriam, Zanaboni, Anna Maria, Facchetti, Sara, De Icco, Roberto, Martinelli, Daniele, Allena, Marta, Greco, Rosaria, Tassorelli, Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10049673/
https://www.ncbi.nlm.nih.gov/pubmed/36982428
http://dx.doi.org/10.3390/ijms24065334
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author Demartini, Chiara
Francavilla, Miriam
Zanaboni, Anna Maria
Facchetti, Sara
De Icco, Roberto
Martinelli, Daniele
Allena, Marta
Greco, Rosaria
Tassorelli, Cristina
author_facet Demartini, Chiara
Francavilla, Miriam
Zanaboni, Anna Maria
Facchetti, Sara
De Icco, Roberto
Martinelli, Daniele
Allena, Marta
Greco, Rosaria
Tassorelli, Cristina
author_sort Demartini, Chiara
collection PubMed
description In recent years, numerous efforts have been made to identify reliable biomarkers useful in migraine diagnosis and progression or associated with the response to a specific treatment. The purpose of this review is to summarize the alleged diagnostic and therapeutic migraine biomarkers found in biofluids and to discuss their role in the pathogenesis of the disease. We included the most informative data from clinical or preclinical studies, with a particular emphasis on calcitonin gene-related peptide (CGRP), cytokines, endocannabinoids, and other biomolecules, the majority of which are related to the inflammatory aspects and mechanisms of migraine, as well as other actors that play a role in the disease. The potential issues affecting biomarker analysis are also discussed, such as how to deal with bias and confounding data. CGRP and other biological factors associated with the trigeminovascular system may offer intriguing and novel precision medicine opportunities, although the biological stability of the samples used, as well as the effects of the confounding role of age, gender, diet, and metabolic factors should be considered.
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spelling pubmed-100496732023-03-29 Biomarkers of Migraine: An Integrated Evaluation of Preclinical and Clinical Findings Demartini, Chiara Francavilla, Miriam Zanaboni, Anna Maria Facchetti, Sara De Icco, Roberto Martinelli, Daniele Allena, Marta Greco, Rosaria Tassorelli, Cristina Int J Mol Sci Review In recent years, numerous efforts have been made to identify reliable biomarkers useful in migraine diagnosis and progression or associated with the response to a specific treatment. The purpose of this review is to summarize the alleged diagnostic and therapeutic migraine biomarkers found in biofluids and to discuss their role in the pathogenesis of the disease. We included the most informative data from clinical or preclinical studies, with a particular emphasis on calcitonin gene-related peptide (CGRP), cytokines, endocannabinoids, and other biomolecules, the majority of which are related to the inflammatory aspects and mechanisms of migraine, as well as other actors that play a role in the disease. The potential issues affecting biomarker analysis are also discussed, such as how to deal with bias and confounding data. CGRP and other biological factors associated with the trigeminovascular system may offer intriguing and novel precision medicine opportunities, although the biological stability of the samples used, as well as the effects of the confounding role of age, gender, diet, and metabolic factors should be considered. MDPI 2023-03-10 /pmc/articles/PMC10049673/ /pubmed/36982428 http://dx.doi.org/10.3390/ijms24065334 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Demartini, Chiara
Francavilla, Miriam
Zanaboni, Anna Maria
Facchetti, Sara
De Icco, Roberto
Martinelli, Daniele
Allena, Marta
Greco, Rosaria
Tassorelli, Cristina
Biomarkers of Migraine: An Integrated Evaluation of Preclinical and Clinical Findings
title Biomarkers of Migraine: An Integrated Evaluation of Preclinical and Clinical Findings
title_full Biomarkers of Migraine: An Integrated Evaluation of Preclinical and Clinical Findings
title_fullStr Biomarkers of Migraine: An Integrated Evaluation of Preclinical and Clinical Findings
title_full_unstemmed Biomarkers of Migraine: An Integrated Evaluation of Preclinical and Clinical Findings
title_short Biomarkers of Migraine: An Integrated Evaluation of Preclinical and Clinical Findings
title_sort biomarkers of migraine: an integrated evaluation of preclinical and clinical findings
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10049673/
https://www.ncbi.nlm.nih.gov/pubmed/36982428
http://dx.doi.org/10.3390/ijms24065334
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