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Biomarkers of Migraine: An Integrated Evaluation of Preclinical and Clinical Findings
In recent years, numerous efforts have been made to identify reliable biomarkers useful in migraine diagnosis and progression or associated with the response to a specific treatment. The purpose of this review is to summarize the alleged diagnostic and therapeutic migraine biomarkers found in bioflu...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10049673/ https://www.ncbi.nlm.nih.gov/pubmed/36982428 http://dx.doi.org/10.3390/ijms24065334 |
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author | Demartini, Chiara Francavilla, Miriam Zanaboni, Anna Maria Facchetti, Sara De Icco, Roberto Martinelli, Daniele Allena, Marta Greco, Rosaria Tassorelli, Cristina |
author_facet | Demartini, Chiara Francavilla, Miriam Zanaboni, Anna Maria Facchetti, Sara De Icco, Roberto Martinelli, Daniele Allena, Marta Greco, Rosaria Tassorelli, Cristina |
author_sort | Demartini, Chiara |
collection | PubMed |
description | In recent years, numerous efforts have been made to identify reliable biomarkers useful in migraine diagnosis and progression or associated with the response to a specific treatment. The purpose of this review is to summarize the alleged diagnostic and therapeutic migraine biomarkers found in biofluids and to discuss their role in the pathogenesis of the disease. We included the most informative data from clinical or preclinical studies, with a particular emphasis on calcitonin gene-related peptide (CGRP), cytokines, endocannabinoids, and other biomolecules, the majority of which are related to the inflammatory aspects and mechanisms of migraine, as well as other actors that play a role in the disease. The potential issues affecting biomarker analysis are also discussed, such as how to deal with bias and confounding data. CGRP and other biological factors associated with the trigeminovascular system may offer intriguing and novel precision medicine opportunities, although the biological stability of the samples used, as well as the effects of the confounding role of age, gender, diet, and metabolic factors should be considered. |
format | Online Article Text |
id | pubmed-10049673 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100496732023-03-29 Biomarkers of Migraine: An Integrated Evaluation of Preclinical and Clinical Findings Demartini, Chiara Francavilla, Miriam Zanaboni, Anna Maria Facchetti, Sara De Icco, Roberto Martinelli, Daniele Allena, Marta Greco, Rosaria Tassorelli, Cristina Int J Mol Sci Review In recent years, numerous efforts have been made to identify reliable biomarkers useful in migraine diagnosis and progression or associated with the response to a specific treatment. The purpose of this review is to summarize the alleged diagnostic and therapeutic migraine biomarkers found in biofluids and to discuss their role in the pathogenesis of the disease. We included the most informative data from clinical or preclinical studies, with a particular emphasis on calcitonin gene-related peptide (CGRP), cytokines, endocannabinoids, and other biomolecules, the majority of which are related to the inflammatory aspects and mechanisms of migraine, as well as other actors that play a role in the disease. The potential issues affecting biomarker analysis are also discussed, such as how to deal with bias and confounding data. CGRP and other biological factors associated with the trigeminovascular system may offer intriguing and novel precision medicine opportunities, although the biological stability of the samples used, as well as the effects of the confounding role of age, gender, diet, and metabolic factors should be considered. MDPI 2023-03-10 /pmc/articles/PMC10049673/ /pubmed/36982428 http://dx.doi.org/10.3390/ijms24065334 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Demartini, Chiara Francavilla, Miriam Zanaboni, Anna Maria Facchetti, Sara De Icco, Roberto Martinelli, Daniele Allena, Marta Greco, Rosaria Tassorelli, Cristina Biomarkers of Migraine: An Integrated Evaluation of Preclinical and Clinical Findings |
title | Biomarkers of Migraine: An Integrated Evaluation of Preclinical and Clinical Findings |
title_full | Biomarkers of Migraine: An Integrated Evaluation of Preclinical and Clinical Findings |
title_fullStr | Biomarkers of Migraine: An Integrated Evaluation of Preclinical and Clinical Findings |
title_full_unstemmed | Biomarkers of Migraine: An Integrated Evaluation of Preclinical and Clinical Findings |
title_short | Biomarkers of Migraine: An Integrated Evaluation of Preclinical and Clinical Findings |
title_sort | biomarkers of migraine: an integrated evaluation of preclinical and clinical findings |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10049673/ https://www.ncbi.nlm.nih.gov/pubmed/36982428 http://dx.doi.org/10.3390/ijms24065334 |
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